Immunofluorescence assays indicate that anguinomycin C is a potent inhibitor of protein export from the nucleus. Key features in the total synthesis of this antitumor natural product include a Cr-catalyzed enantioselective hetero-Diels– Alder reaction, a Negishi reaction with stereoinversion, and application of the DIOZ auxiliary.

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Bonazzi S. et al. Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C // Angewandte Chemie - International Edition. 2007. Vol. 46. No. 45. pp. 8707-8710.

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Bonazzi S., Guttinger S., Zemp I., Kutay U., Gademann K. Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C // Angewandte Chemie - International Edition. 2007. Vol. 46. No. 45. pp. 8707-8710.

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TY - JOUR

DO - 10.1002/anie.200703134

UR - https://doi.org/10.1002/anie.200703134

TI - Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C

T2 - Angewandte Chemie - International Edition

AU - Bonazzi, Simone

AU - Guttinger, Stephan

AU - Zemp, Ivo

AU - Kutay, U.

AU - Gademann, Karl

PY - 2007

DA - 2007/10/04

PB - Wiley

SP - 8707-8710

IS - 45

VL - 46

PMID - 17918172

SN - 1433-7851

SN - 1521-3773

ER -

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@article{2007_Bonazzi,

author = {Simone Bonazzi and Stephan Guttinger and Ivo Zemp and U. Kutay and Karl Gademann},

title = {Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C},

journal = {Angewandte Chemie - International Edition},

year = {2007},

volume = {46},

publisher = {Wiley},

month = {oct},

url = {https://doi.org/10.1002/anie.200703134},

number = {45},

pages = {8707--8710},

doi = {10.1002/anie.200703134}

}

MLA

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Bonazzi, Simone, et al. “Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C.” Angewandte Chemie - International Edition, vol. 46, no. 45, Oct. 2007, pp. 8707-8710. https://doi.org/10.1002/anie.200703134.

Издатель

Wiley

Журнал

Angewandte Chemie - International Edition

scimago Q1

wos Q1

БС1

SJR

5.550

CiteScore

27.6

Impact factor

16.9

ISSN

14337851 (Print)

15213773 (Electronic)