Wiley
Archiv der Pharmazie
,  volume 340 ,  issue 12 ,  pages 650-655

Synthesis and AntiproliferativeIn-Vitro Activity of Natural Flavans and Related Compounds

Liang Zhang 1
, 
En Long Ma 2
, 
Lan Wu 3
, 
Kai Bao 4
, 
Xiao-Long Wang 2
, 
Yu-Ling Wang 5
, 
Hong Rui Song 5
1
 
2
 
3
 
The First Affiliated College, Chinese Medical University, Shenyang, P. R. China | 
4
 
5
 
Publication type: Journal Article
Publication date: 2007-12-01
Wiley
scimago Q2
wos Q2
SJR: 0.571
CiteScore: 7.0
Impact factor: 3.6
ISSN: 03656233, 15214184
Drug Discovery
Pharmaceutical Science
Abstract
The total synthesis of natural flavan racemates (+/-) 1, (+/-) 2 and natural flavones 3, 4 had thus been achieved. A straightforward synthetic procedure of flavans via the Pd-C catalyzed hydrogenation/hydrogenolysis of corresponding flavones was developed. Furthermore, the antiproliferative activities of racemic flavans (+/-) 1, (+/-) 2, flavones 3, 4, and five synthetic intermediates toward human SGC-7901, BEL-7402, HeLa, and HL-60 cell lines in vitro were evaluated by MTT assay, and the racemic flavans (+/-) 1 were found to have significant antiproliferative activity against all four cell lines.
Found 
Found 

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GOST |
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GOST Copy
Zhang L. et al. Synthesis and AntiproliferativeIn-Vitro Activity of Natural Flavans and Related Compounds // Archiv der Pharmazie. 2007. Vol. 340. No. 12. pp. 650-655.
GOST all authors (up to 50) Copy
Zhang L., Ma E. L., Wu L., Bao K., Wang X., Wang Y., Song H. R. Synthesis and AntiproliferativeIn-Vitro Activity of Natural Flavans and Related Compounds // Archiv der Pharmazie. 2007. Vol. 340. No. 12. pp. 650-655.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1002/ardp.200700077
UR - https://doi.org/10.1002/ardp.200700077
TI - Synthesis and AntiproliferativeIn-Vitro Activity of Natural Flavans and Related Compounds
T2 - Archiv der Pharmazie
AU - Zhang, Liang
AU - Ma, En Long
AU - Wu, Lan
AU - Bao, Kai
AU - Wang, Xiao-Long
AU - Wang, Yu-Ling
AU - Song, Hong Rui
PY - 2007
DA - 2007/12/01
PB - Wiley
SP - 650-655
IS - 12
VL - 340
PMID - 17994602
SN - 0365-6233
SN - 1521-4184
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2007_Zhang,
author = {Liang Zhang and En Long Ma and Lan Wu and Kai Bao and Xiao-Long Wang and Yu-Ling Wang and Hong Rui Song},
title = {Synthesis and AntiproliferativeIn-Vitro Activity of Natural Flavans and Related Compounds},
journal = {Archiv der Pharmazie},
year = {2007},
volume = {340},
publisher = {Wiley},
month = {dec},
url = {https://doi.org/10.1002/ardp.200700077},
number = {12},
pages = {650--655},
doi = {10.1002/ardp.200700077}
}
MLA
Cite this
MLA Copy
Zhang, Liang, et al. “Synthesis and AntiproliferativeIn-Vitro Activity of Natural Flavans and Related Compounds.” Archiv der Pharmazie, vol. 340, no. 12, Dec. 2007, pp. 650-655. https://doi.org/10.1002/ardp.200700077.