PF-8380 and Closely Related Analogs: Synthesis and Structure-Activity Relationship towards Autotaxin Inhibition and Glioma Cell Viability
Patrick-Denis St-Coeur
1, 2, 3
,
Dean Ferguson
1, 2, 3
,
Pier Jr Morin
1, 2, 3
,
Mohamed Touaibia
1, 2, 3
Publication type: Journal Article
Publication date: 2013-01-08
scimago Q2
wos Q2
SJR: 0.571
CiteScore: 7.0
Impact factor: 3.6
ISSN: 03656233, 15214184
PubMed ID:
23300119
Drug Discovery
Pharmaceutical Science
Abstract
A series of PF-8380 analogs, a recently developed autotaxin inhibitor, was explored. Inhibition of autotaxin by these analogs, as well as by all PF-8380 synthetic intermediates, shows the importance of meta-dichlorobenzyl and benzo[d]oxazol-2(3H)-one fragments. However, analogs 8 and 9, bearing only the benzo[d]oxazol-2(3H)-one moiety, are more cytotoxic on the LN229 glioblastoma cell line than PF-8380 and temozolomide (TMZ).
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
|
|
|
Cancers
2 publications, 7.69%
|
|
|
International Journal of Molecular Sciences
2 publications, 7.69%
|
|
|
Bioorganic and Medicinal Chemistry
2 publications, 7.69%
|
|
|
Journal of Medicinal Chemistry
2 publications, 7.69%
|
|
|
Molecular Pharmacology
1 publication, 3.85%
|
|
|
Endocrinology
1 publication, 3.85%
|
|
|
Cells
1 publication, 3.85%
|
|
|
Molecular Neurobiology
1 publication, 3.85%
|
|
|
Progress in Lipid Research
1 publication, 3.85%
|
|
|
European Journal of Medicinal Chemistry
1 publication, 3.85%
|
|
|
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
1 publication, 3.85%
|
|
|
Journal of Lipid Research
1 publication, 3.85%
|
|
|
FASEB Journal
1 publication, 3.85%
|
|
|
Medicinal Research Reviews
1 publication, 3.85%
|
|
|
Journal of Heterocyclic Chemistry
1 publication, 3.85%
|
|
|
Chemical Biology and Drug Design
1 publication, 3.85%
|
|
|
Journal not defined
1 publication, 3.85%
|
|
|
FEBS Letters
1 publication, 3.85%
|
|
|
Biomolecules and Therapeutics
1 publication, 3.85%
|
|
|
Mediators of Inflammation
1 publication, 3.85%
|
|
|
Molecular Cancer Therapeutics
1 publication, 3.85%
|
|
|
Molecular Pharmaceutics
1 publication, 3.85%
|
|
|
1
2
|
Publishers
|
1
2
3
4
5
|
|
|
MDPI
5 publications, 19.23%
|
|
|
Elsevier
5 publications, 19.23%
|
|
|
Wiley
5 publications, 19.23%
|
|
|
American Chemical Society (ACS)
3 publications, 11.54%
|
|
|
American Society for Pharmacology and Experimental Therapeutics
1 publication, 3.85%
|
|
|
The Endocrine Society
1 publication, 3.85%
|
|
|
Springer Nature
1 publication, 3.85%
|
|
|
American Society for Biochemistry and Molecular Biology
1 publication, 3.85%
|
|
|
Federation of American Societies for Experimental Biology (FASEB)
1 publication, 3.85%
|
|
|
Korean Society of Applied Pharmacology
1 publication, 3.85%
|
|
|
Hindawi Limited
1 publication, 3.85%
|
|
|
American Association for Cancer Research (AACR)
1 publication, 3.85%
|
|
|
1
2
3
4
5
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
26
Total citations:
26
Citations from 2024:
2
(7.69%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
St-Coeur P. et al. PF-8380 and Closely Related Analogs: Synthesis and Structure-Activity Relationship towards Autotaxin Inhibition and Glioma Cell Viability // Archiv der Pharmazie. 2013. Vol. 346. No. 2. pp. 91-97.
GOST all authors (up to 50)
Copy
St-Coeur P., Ferguson D., Morin P. J., Touaibia M. PF-8380 and Closely Related Analogs: Synthesis and Structure-Activity Relationship towards Autotaxin Inhibition and Glioma Cell Viability // Archiv der Pharmazie. 2013. Vol. 346. No. 2. pp. 91-97.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/ardp.201200395
UR - https://doi.org/10.1002/ardp.201200395
TI - PF-8380 and Closely Related Analogs: Synthesis and Structure-Activity Relationship towards Autotaxin Inhibition and Glioma Cell Viability
T2 - Archiv der Pharmazie
AU - St-Coeur, Patrick-Denis
AU - Ferguson, Dean
AU - Morin, Pier Jr
AU - Touaibia, Mohamed
PY - 2013
DA - 2013/01/08
PB - Wiley
SP - 91-97
IS - 2
VL - 346
PMID - 23300119
SN - 0365-6233
SN - 1521-4184
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2013_St-Coeur,
author = {Patrick-Denis St-Coeur and Dean Ferguson and Pier Jr Morin and Mohamed Touaibia},
title = {PF-8380 and Closely Related Analogs: Synthesis and Structure-Activity Relationship towards Autotaxin Inhibition and Glioma Cell Viability},
journal = {Archiv der Pharmazie},
year = {2013},
volume = {346},
publisher = {Wiley},
month = {jan},
url = {https://doi.org/10.1002/ardp.201200395},
number = {2},
pages = {91--97},
doi = {10.1002/ardp.201200395}
}
Cite this
MLA
Copy
St-Coeur, Patrick-Denis, et al. “PF-8380 and Closely Related Analogs: Synthesis and Structure-Activity Relationship towards Autotaxin Inhibition and Glioma Cell Viability.” Archiv der Pharmazie, vol. 346, no. 2, Jan. 2013, pp. 91-97. https://doi.org/10.1002/ardp.201200395.