Synthesis and Biological Evaluation of a Novel Series of 6,8-Dibromo-4(3H)quinazolinone Derivatives as Anticancer Agents
Publication type: Journal Article
Publication date: 2013-07-22
scimago Q2
wos Q2
SJR: 0.571
CiteScore: 7.0
Impact factor: 3.6
ISSN: 03656233, 15214184
PubMed ID:
23873839
Drug Discovery
Pharmaceutical Science
Abstract
Three novel series of 6,8-dibromo-4(3H)quinazolinone derivatives were synthesized. Some of the novel quinazolinone derivatives were tested for their antitumor activity against the human breast carcinoma cell line MCF-7. Compounds XIIIb, IX, XIVd, XIVb, XIVe, XIIIa, XIVc, XVc, and XIVa exerted powerful cytotoxic effects against the MCF7 cells, with very low IC50 values compared to doxorubicin (positive control). The IC50 values were 1.7, 1.8, 1.83, 5.4, 6.84, 10.8, 13.9, 15.7, and 29.6 µg/mL, respectively.
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Total citations:
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Citations from 2024:
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(14.28%)
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GOST
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Ahmed M. F., Youns M. Synthesis and Biological Evaluation of a Novel Series of 6,8-Dibromo-4(3H)quinazolinone Derivatives as Anticancer Agents // Archiv der Pharmazie. 2013. Vol. 346. No. 8. pp. 610-617.
GOST all authors (up to 50)
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Ahmed M. F., Youns M. Synthesis and Biological Evaluation of a Novel Series of 6,8-Dibromo-4(3H)quinazolinone Derivatives as Anticancer Agents // Archiv der Pharmazie. 2013. Vol. 346. No. 8. pp. 610-617.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/ardp.201300158
UR - https://doi.org/10.1002/ardp.201300158
TI - Synthesis and Biological Evaluation of a Novel Series of 6,8-Dibromo-4(3H)quinazolinone Derivatives as Anticancer Agents
T2 - Archiv der Pharmazie
AU - Ahmed, Marwa F
AU - Youns, Mahmoud
PY - 2013
DA - 2013/07/22
PB - Wiley
SP - 610-617
IS - 8
VL - 346
PMID - 23873839
SN - 0365-6233
SN - 1521-4184
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2013_Ahmed,
author = {Marwa F Ahmed and Mahmoud Youns},
title = {Synthesis and Biological Evaluation of a Novel Series of 6,8-Dibromo-4(3H)quinazolinone Derivatives as Anticancer Agents},
journal = {Archiv der Pharmazie},
year = {2013},
volume = {346},
publisher = {Wiley},
month = {jul},
url = {https://doi.org/10.1002/ardp.201300158},
number = {8},
pages = {610--617},
doi = {10.1002/ardp.201300158}
}
Cite this
MLA
Copy
Ahmed, Marwa F., and Mahmoud Youns. “Synthesis and Biological Evaluation of a Novel Series of 6,8-Dibromo-4(3H)quinazolinone Derivatives as Anticancer Agents.” Archiv der Pharmazie, vol. 346, no. 8, Jul. 2013, pp. 610-617. https://doi.org/10.1002/ardp.201300158.