,
volume 100
,
issue 8
,
pages 608-622
Traffic jam in the primitive streak: The role of defective mesoderm migration in birth defects
1
Pennington Biomedical Research Center; Department of Developmental Biology; Baton Rouge Louisiana
|
2
Pennington Biomedical Research Center; Laboratory for Regulation of Gene Expression; Baton Rouge Louisiana
|
Publication type: Journal Article
Publication date: 2014-08-13
SJR: —
CiteScore: —
Impact factor: —
ISSN: 15420752, 15420760
PubMed ID:
25115487
General Medicine
Developmental Biology
Embryology
Pediatrics, Perinatology and Child Health
Abstract
Gastrulation is the process in which the three germ layers are formed that contribute to the formation of all major tissues in the developing embryo. We here review mouse genetic models in which defective gastrulation leads to mesoderm insufficiencies in the embryo. Depending on severity of the abnormalities, the outcomes range from incompatible with embryonic survival to structural birth defects, such as heart defects, spina bifida, or caudal dysgenesis. The combined evidence from the mutant models supports the notion that these congenital anomalies can originate from perturbations of mesoderm specification, epithelial-mesenchymal transition, and mesodermal cell migration. Knowledge about the molecular pathways involved may help to improve strategies for the prevention of major structural birth defects.
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Total citations:
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Citations from 2024:
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(21.74%)
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Cite this
GOST
Copy
Herion N. J., SALBAUM J. M., Kappen C. Traffic jam in the primitive streak: The role of defective mesoderm migration in birth defects // Birth Defects Research Part A Clinical and Molecular Teratology. 2014. Vol. 100. No. 8. pp. 608-622.
GOST all authors (up to 50)
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Herion N. J., SALBAUM J. M., Kappen C. Traffic jam in the primitive streak: The role of defective mesoderm migration in birth defects // Birth Defects Research Part A Clinical and Molecular Teratology. 2014. Vol. 100. No. 8. pp. 608-622.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/bdra.23283
UR - https://doi.org/10.1002/bdra.23283
TI - Traffic jam in the primitive streak: The role of defective mesoderm migration in birth defects
T2 - Birth Defects Research Part A Clinical and Molecular Teratology
AU - Herion, Nils J
AU - SALBAUM, J. MICHAEL
AU - Kappen, Claudia
PY - 2014
DA - 2014/08/13
PB - Wiley
SP - 608-622
IS - 8
VL - 100
PMID - 25115487
SN - 1542-0752
SN - 1542-0760
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2014_Herion,
author = {Nils J Herion and J. MICHAEL SALBAUM and Claudia Kappen},
title = {Traffic jam in the primitive streak: The role of defective mesoderm migration in birth defects},
journal = {Birth Defects Research Part A Clinical and Molecular Teratology},
year = {2014},
volume = {100},
publisher = {Wiley},
month = {aug},
url = {https://doi.org/10.1002/bdra.23283},
number = {8},
pages = {608--622},
doi = {10.1002/bdra.23283}
}
Cite this
MLA
Copy
Herion, Nils J., et al. “Traffic jam in the primitive streak: The role of defective mesoderm migration in birth defects.” Birth Defects Research Part A Clinical and Molecular Teratology, vol. 100, no. 8, Aug. 2014, pp. 608-622. https://doi.org/10.1002/bdra.23283.