Interaction of antitumoral 9-aminoacridine drug with DNA and dextran sulfate studied by fluorescence and surface-enhanced Raman spectroscopy
Publication type: Journal Article
Publication date: 2003-04-25
scimago Q2
wos Q2
SJR: 0.554
CiteScore: 5.4
Impact factor: 3.2
ISSN: 00063525, 10970282
PubMed ID:
12722113
Organic Chemistry
Biochemistry
General Medicine
Biophysics
Biomaterials
Abstract
Fluorescence spectroscopy and surface-enhanced Raman spectroscopy are applied to study the interaction of the drug 9-aminoacridine (9AA) with DNA and dextran sulfate. The effect of the electrostatic interaction between the positively charged 9AA and negatively charged groups in relation to the excimer or exciplex emission is investigated. The exciplex emission of 9AA is connected to the intercalation of this drug between nucleic base residues. The importance of negative groups in this interaction is evaluated by using dextran and dextran sulfate as model polymers. The existence of negative charges seems to induce an increase of the drug concentration in the vicinity of the polymers. The role of electrostatic attraction in the 9AA dimerization is confirmed by the excimer emission of 9AA in the presence of dextran sulfate. In the case of DNA, the phosphate groups may induce the drug approach to the DNA chain, but the exciplex fluorescence emission could be due to a charge transfer between the drug and adenine-rich sequences of DNA. © 2003 Wiley Periodicals, Inc. Biopolymers (Biospectroscopy) 72: 174–184, 2003
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GOST
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Murza A. et al. Interaction of antitumoral 9-aminoacridine drug with DNA and dextran sulfate studied by fluorescence and surface-enhanced Raman spectroscopy // Biopolymers. 2003. Vol. 72. No. 3. pp. 174-184.
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Murza A., Alvarez Méndez S., Sànchez-Cortés S., García-Ramos J. V. Interaction of antitumoral 9-aminoacridine drug with DNA and dextran sulfate studied by fluorescence and surface-enhanced Raman spectroscopy // Biopolymers. 2003. Vol. 72. No. 3. pp. 174-184.
Cite this
RIS
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TY - JOUR
DO - 10.1002/bip.10336
UR - https://doi.org/10.1002/bip.10336
TI - Interaction of antitumoral 9-aminoacridine drug with DNA and dextran sulfate studied by fluorescence and surface-enhanced Raman spectroscopy
T2 - Biopolymers
AU - Murza, Adrian
AU - Alvarez Méndez, Sergio
AU - Sànchez-Cortés, Santiago
AU - García-Ramos, José V.
PY - 2003
DA - 2003/04/25
PB - Wiley
SP - 174-184
IS - 3
VL - 72
PMID - 12722113
SN - 0006-3525
SN - 1097-0282
ER -
Cite this
BibTex (up to 50 authors)
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@article{2003_Murza,
author = {Adrian Murza and Sergio Alvarez Méndez and Santiago Sànchez-Cortés and José V. García-Ramos},
title = {Interaction of antitumoral 9-aminoacridine drug with DNA and dextran sulfate studied by fluorescence and surface-enhanced Raman spectroscopy},
journal = {Biopolymers},
year = {2003},
volume = {72},
publisher = {Wiley},
month = {apr},
url = {https://doi.org/10.1002/bip.10336},
number = {3},
pages = {174--184},
doi = {10.1002/bip.10336}
}
Cite this
MLA
Copy
Murza, Adrian, et al. “Interaction of antitumoral 9-aminoacridine drug with DNA and dextran sulfate studied by fluorescence and surface-enhanced Raman spectroscopy.” Biopolymers, vol. 72, no. 3, Apr. 2003, pp. 174-184. https://doi.org/10.1002/bip.10336.