Cholinesterase-catalyzed resolution ofD,L-carnitine
Publication type: Journal Article
Publication date: 1984-08-01
scimago Q2
wos Q2
SJR: 0.940
CiteScore: 8.0
Impact factor: 3.6
ISSN: 00063592, 10970290
PubMed ID:
18553477
Applied Microbiology and Biotechnology
Biotechnology
Bioengineering
Abstract
An enzymatic method for the preparative resolution of racemic carnitine (whose L-isomer and its acyl-derivatives have numerous therapeutical applications) has been developed. It is based on our finding that electriceel acetylcholinesterase hydrolyzes the D- but not the L-isomer of acetylcarnitine. (Another cholinesterase tested, horse serum butyrylcholinesterase, is also stereospecific and hydrolyzes only the L-isomer of butyrylcarnitine.) Acetylcholinesterase, covalently attached to alumina, was employed for the resolution of D,L-carnitine; the latter was first chemically acetylated, then stereoselectively hydrolyzed with the immobilized enzyme, and finally the acetyl-L-carnitine and D-carnitine produced were separated by ion-exchange chromatography. Gram quantities of D,L-carnitine were thereby resolved.
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Total citations:
30
Citations from 2024:
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GOST
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Dropsy E. P., Klibanov A. M. Cholinesterase-catalyzed resolution ofD,L-carnitine // Biotechnology and Bioengineering. 1984. Vol. 26. No. 8. pp. 911-915.
GOST all authors (up to 50)
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Dropsy E. P., Klibanov A. M. Cholinesterase-catalyzed resolution ofD,L-carnitine // Biotechnology and Bioengineering. 1984. Vol. 26. No. 8. pp. 911-915.
Cite this
RIS
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TY - JOUR
DO - 10.1002/bit.260260815
UR - https://doi.org/10.1002/bit.260260815
TI - Cholinesterase-catalyzed resolution ofD,L-carnitine
T2 - Biotechnology and Bioengineering
AU - Dropsy, Eric P
AU - Klibanov, Alexander M.
PY - 1984
DA - 1984/08/01
PB - Wiley
SP - 911-915
IS - 8
VL - 26
PMID - 18553477
SN - 0006-3592
SN - 1097-0290
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1984_Dropsy,
author = {Eric P Dropsy and Alexander M. Klibanov},
title = {Cholinesterase-catalyzed resolution ofD,L-carnitine},
journal = {Biotechnology and Bioengineering},
year = {1984},
volume = {26},
publisher = {Wiley},
month = {aug},
url = {https://doi.org/10.1002/bit.260260815},
number = {8},
pages = {911--915},
doi = {10.1002/bit.260260815}
}
Cite this
MLA
Copy
Dropsy, Eric P., and Alexander M. Klibanov. “Cholinesterase-catalyzed resolution ofD,L-carnitine.” Biotechnology and Bioengineering, vol. 26, no. 8, Aug. 1984, pp. 911-915. https://doi.org/10.1002/bit.260260815.