The metabolic fate of the synthetic prostaglandin cloprostenol (‘Estrumate’) in the cow: Use of ion cluster techniques to facilitate metabolite identification
1
Safety of Medicines Department, ICI Pharmaceuticals Division, Alderley Park, Nr Macclesfield, Cheshire SK10 4TG, UK
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Publication type: Journal Article
Publication date: 1980-05-01
scimago Q3
wos Q2
SJR: 0.427
CiteScore: 4.0
Impact factor: 2.0
ISSN: 10765174, 10969888
PubMed ID:
7417700
Biochemistry
Spectroscopy
Molecular Medicine
Abstract
The metabolic fate of the synthetic prostaglandin cloprostenol ('Estrumate') in the cow has been studied. Following intramuscular administration of 0.5 mg and 10 mg of [14C]cloprostenol to cows urinary excretion accounted for 58.2% and 56.3% of the dose respectively. Unchanged cloprostenol and its tetranor acid, probably formed by beta-oxidation, were the major components identified in urine. The tetranor acid was also present as a glucuronide conjugate. This synthetic prostaglandin analogue is apparently a poor substrate for the enzymes 15-hydroxyprostaglandin dehydrogenase and 13,14-reductase, which are responsible for the rapid metabolic deactivation of endogenous prostaglandins, as no components identified in urine were found to have undergone metabolic attack at the C-15 atom in the cloprostenol molecule.
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Bourne G. R. et al. The metabolic fate of the synthetic prostaglandin cloprostenol (‘Estrumate’) in the cow: Use of ion cluster techniques to facilitate metabolite identification // Journal of Mass Spectrometry. 1980. Vol. 7. No. 5. pp. 226-230.
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Bourne G. R., Moss S. R., PHILLIPS P. J., Shuker B. The metabolic fate of the synthetic prostaglandin cloprostenol (‘Estrumate’) in the cow: Use of ion cluster techniques to facilitate metabolite identification // Journal of Mass Spectrometry. 1980. Vol. 7. No. 5. pp. 226-230.
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RIS
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TY - JOUR
DO - 10.1002/bms.1200070509
UR - https://doi.org/10.1002/bms.1200070509
TI - The metabolic fate of the synthetic prostaglandin cloprostenol (‘Estrumate’) in the cow: Use of ion cluster techniques to facilitate metabolite identification
T2 - Journal of Mass Spectrometry
AU - Bourne, G R
AU - Moss, S. R.
AU - PHILLIPS, P. J.
AU - Shuker, B
PY - 1980
DA - 1980/05/01
PB - Wiley
SP - 226-230
IS - 5
VL - 7
PMID - 7417700
SN - 1076-5174
SN - 1096-9888
ER -
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BibTex (up to 50 authors)
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@article{1980_Bourne,
author = {G R Bourne and S. R. Moss and P. J. PHILLIPS and B Shuker},
title = {The metabolic fate of the synthetic prostaglandin cloprostenol (‘Estrumate’) in the cow: Use of ion cluster techniques to facilitate metabolite identification},
journal = {Journal of Mass Spectrometry},
year = {1980},
volume = {7},
publisher = {Wiley},
month = {may},
url = {https://doi.org/10.1002/bms.1200070509},
number = {5},
pages = {226--230},
doi = {10.1002/bms.1200070509}
}
Cite this
MLA
Copy
Bourne, G. R., et al. “The metabolic fate of the synthetic prostaglandin cloprostenol (‘Estrumate’) in the cow: Use of ion cluster techniques to facilitate metabolite identification.” Journal of Mass Spectrometry, vol. 7, no. 5, May. 1980, pp. 226-230. https://doi.org/10.1002/bms.1200070509.