volume 105 issue 3 pages 698-706

Impact of Below‐the‐Knee Runoff in Patients With Lower Extremity Artery Disease Who Underwent Endovascular Therapy Using Drug‐Coated Balloons in Femoropopliteal Lesions

Takehiro Yamada 1
Takahiro Tokuda 2
Naoki Yoshioka 3
Akio KOYAMA 4
Ryusuke Nishikawa 5
Kiyotaka SHIMAMURA 6
Takuya TSURUOKA 7
Hiroki Mitsuoka 8
Yusuke Sato 9
Takuma Aoyama 1, 10
1
 
Department of Cardiology Central Japan International Medical Center Minokamo Japan
2
 
Department of Cardiology Nagoya Heart Center Nagoya Aichi Japan
4
 
Department of Vascular Surgery Toyota Memorial Hospital Toyota Aichi Japan
7
 
Department of Vascular Surgery Ichinomiya Municipal Hospital Ichinomiya Aichi Japan
Publication typeJournal Article
Publication date2024-12-24
scimago Q1
wos Q3
SJR1.010
CiteScore5.1
Impact factor1.9
ISSN15221946, 1522726X
PubMed ID:  39718411
Abstract
ABSTRACT
Background

The impact of below‐the‐knee (BK) runoff after drug‐coated balloon (DCB) treatment in femoropopliteal (FP) lesions has not been well investigated.

Methods

This retrospective multicenter observational study enrolled 291 consecutive patients with lower extremity artery disease who underwent endovascular therapy with DCBs for FP lesions between January 2018 and December 2021. Patients were classified into four groups based on the BK runoff. Outcome measures included primary patency, freedom from clinically driven target lesion revascularization (CD‐TLR) and amputation, and overall survival rates at 24 months. The predictors of restenosis at 24 months were also investigated.

Results

In total, 43, 98, 117, and 33 patients were classified into three, two, one, and no BK runoff groups, respectively. In three, two, one, and no BK runoff groups, the primary patency rates were 72.1%, 67.3%, 61.4%, and 44.1% (p = 0.028); freedom from CD‐TLR rates were 87.1%, 78.8%, 71.7%, and 47.1% (p < 0.001); freedom from amputation rates were 95.2%, 97.9%, 92.8%, and 91.5% (p = 0.499); and overall survival rates were 89.4%, 83.2%, 76.6%, and 61.2% (p = 0.007), respectively, at 24 months. Multivariate analysis showed that chronic limb‐threatening ischemia, no BK runoff, Lutonix use, and residual stenosis > 30% were independent predictors of primary patency loss at 24 months. The risk score, calculated as the number of predictors, reflected the risk of restenosis.

Conclusion

No BK runoff was associated with worse midterm primary patency, freedom from CD‐TLR, and overall survival rates than at least one BK runoff.

Found 
Found 

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Catheterization and Cardiovascular Interventions
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Yamada T. et al. Impact of Below‐the‐Knee Runoff in Patients With Lower Extremity Artery Disease Who Underwent Endovascular Therapy Using Drug‐Coated Balloons in Femoropopliteal Lesions // Catheterization and Cardiovascular Interventions. 2024. Vol. 105. No. 3. pp. 698-706.
GOST all authors (up to 50) Copy
Yamada T., Tokuda T., Yoshioka N., KOYAMA A., Nishikawa R., SHIMAMURA K., TSURUOKA T., Mitsuoka H., Sato Y., Aoyama T. Impact of Below‐the‐Knee Runoff in Patients With Lower Extremity Artery Disease Who Underwent Endovascular Therapy Using Drug‐Coated Balloons in Femoropopliteal Lesions // Catheterization and Cardiovascular Interventions. 2024. Vol. 105. No. 3. pp. 698-706.
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RIS Copy
TY - JOUR
DO - 10.1002/ccd.31375
UR - https://onlinelibrary.wiley.com/doi/10.1002/ccd.31375
TI - Impact of Below‐the‐Knee Runoff in Patients With Lower Extremity Artery Disease Who Underwent Endovascular Therapy Using Drug‐Coated Balloons in Femoropopliteal Lesions
T2 - Catheterization and Cardiovascular Interventions
AU - Yamada, Takehiro
AU - Tokuda, Takahiro
AU - Yoshioka, Naoki
AU - KOYAMA, Akio
AU - Nishikawa, Ryusuke
AU - SHIMAMURA, Kiyotaka
AU - TSURUOKA, Takuya
AU - Mitsuoka, Hiroki
AU - Sato, Yusuke
AU - Aoyama, Takuma
PY - 2024
DA - 2024/12/24
PB - Wiley
SP - 698-706
IS - 3
VL - 105
PMID - 39718411
SN - 1522-1946
SN - 1522-726X
ER -
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@article{2024_Yamada,
author = {Takehiro Yamada and Takahiro Tokuda and Naoki Yoshioka and Akio KOYAMA and Ryusuke Nishikawa and Kiyotaka SHIMAMURA and Takuya TSURUOKA and Hiroki Mitsuoka and Yusuke Sato and Takuma Aoyama},
title = {Impact of Below‐the‐Knee Runoff in Patients With Lower Extremity Artery Disease Who Underwent Endovascular Therapy Using Drug‐Coated Balloons in Femoropopliteal Lesions},
journal = {Catheterization and Cardiovascular Interventions},
year = {2024},
volume = {105},
publisher = {Wiley},
month = {dec},
url = {https://onlinelibrary.wiley.com/doi/10.1002/ccd.31375},
number = {3},
pages = {698--706},
doi = {10.1002/ccd.31375}
}
MLA
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MLA Copy
Yamada, Takehiro, et al. “Impact of Below‐the‐Knee Runoff in Patients With Lower Extremity Artery Disease Who Underwent Endovascular Therapy Using Drug‐Coated Balloons in Femoropopliteal Lesions.” Catheterization and Cardiovascular Interventions, vol. 105, no. 3, Dec. 2024, pp. 698-706. https://onlinelibrary.wiley.com/doi/10.1002/ccd.31375.