European Journal of Organic Chemistry
Solvent‐Directed Regioselective Cascade Reaction with Diazo Compounds
Menghua Dong
1, 2, 3
,
Chunan Wang
2, 3, 4
,
Lewan Li
2, 3, 4
,
Yufan Chen
2, 4
,
Jie Zeng
3, 5
,
Jian Lv
3, 5
,
Jie Liao
6, 7
,
Haifeng Wang
2, 3, 8, 9
,
Shuang-Xi Gu
10
,
Shuangxi Gu
2, 3, 8
,
Fen-Er Chen
11
,
Fener Chen
3, 12
7
Hubei Industrial Technology Institute of Dye Intermediates Shishou 434400 China
|
8
Key laboratory of Green Chemcial Engineering Precess of Ministry of Education Wuhan 430205 China
|
9
Hubei Key Laboratory of Novel Reactor and Green Chemical Technolog Wuhan 430205 China
12
Shanghai Engineering Center of Industrial Catalysis for Chiral Drugs Shanghai 200433 China
|
Publication type: Journal Article
Publication date: 2025-01-10
scimago Q2
SJR: 0.584
CiteScore: 5.4
Impact factor: 2.5
ISSN: 1434193X, 10990690
Abstract
A tandem system comprising cyclization reaction of diazo compound and cross‐coupling of the other one has been developed. This provides facile access to pyrazoles and there derivatives with high levels of regioselectivity in moderate to good yields. This process uniquely utilizes CF3CH2OTf both as a solvent and a catalyst under mild conditions. Mechanistic studies provide insights into the intricate sequence involved in the formation of pyrazoles and further selective cross‐coupling with another diazo compound.
Found
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