Journal of Biophotonics

, volume 16 , issue 1

Studying the genotoxic effects of high intensity terahertz radiation on fibroblasts and CNS tumor cells

Dmitry S. Sitnikov ¹

Veronika A Revkova ^{2, 3}

Inna V Ilina ¹

Svetlana A Gurova ⁴

Pavel S Komarov ¹

Evgenia V Struleva ¹

Mikhail A Konoplyannikov ^{2, 5}

Vladimir A Kalsin ^{2, 3}

Vladimir P. Baklaushev ^{2, 3}

Hide authors affiliations Show authors affiliations: 5 affiliations

Joint Institute for High Temperatures of the Russian Academy of Sciences Moscow Russia |

Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia Moscow Russia |

Engelhardt Institute of Molecular Biology Russian Academy of Sciences Moscow Russia |

⁴

Obninsk Institute for Nuclear Power Engineering National Research Nuclear University MEPhI Obninsk Russia |

⁵

Institute for Regenerative Medicine Sechenov First Moscow State Medical University Moscow Russia |

Publication type: Journal Article

Publication date: 2022-10-27

Wiley

Journal of Biophotonics

scimago Q2

wos Q3

SJR: 0.531

CiteScore: 4.7

Impact factor: 2.3

ISSN: 1864063X, 18640648

DOI: 10.1002/jbio.202200212

Copy DOI

PubMed ID: 36250985

General Chemistry

General Biochemistry, Genetics and Molecular Biology

General Physics and Astronomy

General Materials Science

General Engineering

Abstract

The data is obtained on the effect of high-intensity pulses of terahertz (THz) radiation with a broad spectrum (0.2-3 THz) on cell cultures. We have evaluated the threshold exposure parameters of THz radiation causing genotoxic effects in fibroblasts. Phosphorylation of histone H2AX at Ser 139 (γH2AX) was chosen as a marker for genotoxicity and a quantitative estimation of γH2AX foci number in fibroblasts was performed after cell irradiation with THz pulses for 30 min. No genotoxic effects of THz radiation were observed in fibroblasts unless peak intensity and electric field strength exceeded 21 GW cm-2 and 2.8 MV cm-1 , respectively. In tumor cell lines (neuroblastoma (SK-N-BE (2)) and glioblastoma (U87)), exposure to THz pulses with peak intensity of 21 GW cm-2 for 30 min caused no morphological changes as well as no statistically significant increase in histone phosphorylation foci number.

Found

1 citation

Rytik Andrey

21 publications, 13 citations, 1 review

h-index: 3

Saratov State University

Research interests

Biomedical instrumentation

1 citation

Oliveira Luís

72 publications, 778 citations, 12 reviews

h-index: 17

Polytechnic Institute of Porto

Research interests

Biomedical engineering

Biophotonics

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GOST Copy

Sitnikov D. S. et al. Studying the genotoxic effects of high intensity terahertz radiation on fibroblasts and CNS tumor cells // Journal of Biophotonics. 2022. Vol. 16. No. 1.

GOST all authors (up to 50) Copy

Sitnikov D. S., Revkova V. A., Ilina I. V., Gurova S. A., Komarov P. S., Struleva E. V., Konoplyannikov M. A., Kalsin V. A., Baklaushev V. P. Studying the genotoxic effects of high intensity terahertz radiation on fibroblasts and CNS tumor cells // Journal of Biophotonics. 2022. Vol. 16. No. 1.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1002/jbio.202200212

UR - https://doi.org/10.1002/jbio.202200212

TI - Studying the genotoxic effects of high intensity terahertz radiation on fibroblasts and CNS tumor cells

T2 - Journal of Biophotonics

AU - Sitnikov, Dmitry S.

AU - Revkova, Veronika A

AU - Ilina, Inna V

AU - Gurova, Svetlana A

AU - Komarov, Pavel S

AU - Struleva, Evgenia V

AU - Konoplyannikov, Mikhail A

AU - Kalsin, Vladimir A

AU - Baklaushev, Vladimir P.

PY - 2022

DA - 2022/10/27

PB - Wiley

IS - 1

VL - 16

PMID - 36250985

SN - 1864-063X

SN - 1864-0648

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2022_Sitnikov,

author = {Dmitry S. Sitnikov and Veronika A Revkova and Inna V Ilina and Svetlana A Gurova and Pavel S Komarov and Evgenia V Struleva and Mikhail A Konoplyannikov and Vladimir A Kalsin and Vladimir P. Baklaushev},

title = {Studying the genotoxic effects of high intensity terahertz radiation on fibroblasts and CNS tumor cells},

journal = {Journal of Biophotonics},

year = {2022},

volume = {16},

publisher = {Wiley},

month = {oct},

url = {https://doi.org/10.1002/jbio.202200212},

number = {1},

doi = {10.1002/jbio.202200212}

}

Publisher

Wiley

Journal

Journal of Biophotonics

scimago Q2

wos Q3

SJR

0.531

CiteScore

4.7

Impact factor

2.3

ISSN

1864063X (Print)

18640648 (Electronic)