An Efficient and Facile Synthesis of 5-(Thiophene-2-carbonyl)-6-(trifluoromethyl)-tetrahydro-pyrimidin-2(1H)-one and 6-(Thiophen-2-yl)-4,5-dihydropyrimidin-2(1H)-one from Same Substrates Under Different Conditions
Publication type: Journal Article
Publication date: 2014-12-22
scimago Q3
wos Q2
SJR: 0.362
CiteScore: 4.7
Impact factor: 2.4
ISSN: 0022152X, 19435193
Organic Chemistry
Abstract
A series of 5-(thiophene-2-carbonyl)-6-(trifluoromethyl)-tetrahydropyrimidin-2(1H)-one and 6-(thiophen-2-yl)-4,5-dihydropyrimidin-2(1H)-one derivatives have been synthesized from the reactions of aromatic aldehydes, 4,4,4-trifluoro-1-(thien-2-yl)butane-1,3-dione and urea under the different conditions with high yields. In this research, it was found that the p-toluenesulfonic acid was an efficient catalyst for obtaining 5-(thiophene-2-carbonyl)-6-(trifluoromethyl)-tetrahydropyrimidin-2(1H)-one derivative. At the same time, solvent-free and NaOH were the preferred conditions for the synthesis of 6-(thiophen-2-yl)-4,5-dihydropyrimidin-2(1H)-one derivative. Moreover, because of short reaction time, excellent yields, simple setup, this research offered an efficient process for preparing these kind compounds.
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Rong L. et al. An Efficient and Facile Synthesis of 5-(Thiophene-2-carbonyl)-6-(trifluoromethyl)-tetrahydro-pyrimidin-2(1H)-one and 6-(Thiophen-2-yl)-4,5-dihydropyrimidin-2(1H)-one from Same Substrates Under Different Conditions // Journal of Heterocyclic Chemistry. 2014. Vol. 53. No. 1. pp. 56-63.
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Rong L., Zha Y., Xia S., Ji L., Zhang J., Cai P. An Efficient and Facile Synthesis of 5-(Thiophene-2-carbonyl)-6-(trifluoromethyl)-tetrahydro-pyrimidin-2(1H)-one and 6-(Thiophen-2-yl)-4,5-dihydropyrimidin-2(1H)-one from Same Substrates Under Different Conditions // Journal of Heterocyclic Chemistry. 2014. Vol. 53. No. 1. pp. 56-63.
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TY - JOUR
DO - 10.1002/jhet.2299
UR - https://doi.org/10.1002/jhet.2299
TI - An Efficient and Facile Synthesis of 5-(Thiophene-2-carbonyl)-6-(trifluoromethyl)-tetrahydro-pyrimidin-2(1H)-one and 6-(Thiophen-2-yl)-4,5-dihydropyrimidin-2(1H)-one from Same Substrates Under Different Conditions
T2 - Journal of Heterocyclic Chemistry
AU - Rong, Liang-Ce
AU - Zha, Yunyun
AU - Xia, Sheng
AU - Ji, Linlin
AU - Zhang, Jing
AU - Cai, Peijun
PY - 2014
DA - 2014/12/22
PB - Wiley
SP - 56-63
IS - 1
VL - 53
SN - 0022-152X
SN - 1943-5193
ER -
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BibTex (up to 50 authors)
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@article{2014_Rong,
author = {Liang-Ce Rong and Yunyun Zha and Sheng Xia and Linlin Ji and Jing Zhang and Peijun Cai},
title = {An Efficient and Facile Synthesis of 5-(Thiophene-2-carbonyl)-6-(trifluoromethyl)-tetrahydro-pyrimidin-2(1H)-one and 6-(Thiophen-2-yl)-4,5-dihydropyrimidin-2(1H)-one from Same Substrates Under Different Conditions},
journal = {Journal of Heterocyclic Chemistry},
year = {2014},
volume = {53},
publisher = {Wiley},
month = {dec},
url = {https://doi.org/10.1002/jhet.2299},
number = {1},
pages = {56--63},
doi = {10.1002/jhet.2299}
}
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MLA
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Rong, Liang-Ce, et al. “An Efficient and Facile Synthesis of 5-(Thiophene-2-carbonyl)-6-(trifluoromethyl)-tetrahydro-pyrimidin-2(1H)-one and 6-(Thiophen-2-yl)-4,5-dihydropyrimidin-2(1H)-one from Same Substrates Under Different Conditions.” Journal of Heterocyclic Chemistry, vol. 53, no. 1, Dec. 2014, pp. 56-63. https://doi.org/10.1002/jhet.2299.