Journal of Heterocyclic Chemistry, volume 42, issue 4, pages 661-667
A novel route to the 5,6-dihydro-4-H-thieno[3,2-b]pyrrol-5-one ring system involving an intermediate substituted-thiophene synthesis
Shuanghua Hu
1
,
Yazhong Huang
1
,
Michael A Poss
1
,
Robert G. Gentles
1
1
Early Discovery Chemistry, Pharmaceutical Research Institute, Bristol‐Myers Squibb Company, 5 Research Parkway, Wallingford, CT. 06492 USA
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Publication type: Journal Article
Publication date: 2005-05-01
Journal:
Journal of Heterocyclic Chemistry
scimago Q3
wos Q2
SJR: 0.360
CiteScore: 5.2
Impact factor: 2
ISSN: 0022152X, 19435193
Organic Chemistry
Abstract
A novel route to electron-deficient thienopyrrolones is disclosed. The target heterocycles are concisely constructed by condensation of activated α- or β-halo-substituted acrylonitriles, or ortho-substituted halo, cyano heterocycles with mercaptopyruvate, followed by reduction and subsequent lactamization.
Found
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