Wiley
Journal of Labelled Compounds and Radiopharmaceuticals
,  volume 7 ,  issue 4 ,  pages 431-439

Synthesis of 15α, 15β, 21, 21, 21−3H5-pregn-5-en-3β-ol-20-one

B M Ranzi 1
, 
F. Ronchetti 1
, 
G. Russo 1
1
 
Istituto di Chimica Organica della Facoltà di Scienze dell'Università Via Saldini 50 ‐ Milano (Italy) | 
Publication type: Journal Article
Publication date: 1971-10-01
Wiley
scimago Q3
wos Q4
SJR: 0.271
CiteScore: 2.0
Impact factor: 0.9
ISSN: 03624803, 10991344
Organic Chemistry
Drug Discovery
Biochemistry
Spectroscopy
General Medicine
Analytical Chemistry
Radiology, Nuclear Medicine and imaging
Abstract
The readily accessible pregna-5,16-dien-3 β-ol-20-one (1) was transformed into 3β-acetoxy-pregna-5,17-dien-20-isopropoxy-16-one (9). This compound was labelled by base-catalyzed isotopic exchange and then reconverted into labelled pregna-5,16-dien-3β-ol-20-one (13). Hydrogenation of this last one furnished the title compound (14). The labelling extent in the 15α,15β and 21 positions was determined by combined chemical and microbiological methods.
Found 

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Ranzi B. M., Ronchetti F., Russo G. Synthesis of 15α, 15β, 21, 21, 21−3H5-pregn-5-en-3β-ol-20-one // Journal of Labelled Compounds and Radiopharmaceuticals. 1971. Vol. 7. No. 4. pp. 431-439.
GOST all authors (up to 50) Copy
Ranzi B. M., Ronchetti F., Russo G. Synthesis of 15α, 15β, 21, 21, 21−3H5-pregn-5-en-3β-ol-20-one // Journal of Labelled Compounds and Radiopharmaceuticals. 1971. Vol. 7. No. 4. pp. 431-439.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1002/jlcr.2590070407
UR - https://doi.org/10.1002/jlcr.2590070407
TI - Synthesis of 15α, 15β, 21, 21, 21−3H5-pregn-5-en-3β-ol-20-one
T2 - Journal of Labelled Compounds and Radiopharmaceuticals
AU - Ranzi, B M
AU - Ronchetti, F.
AU - Russo, G.
PY - 1971
DA - 1971/10/01
PB - Wiley
SP - 431-439
IS - 4
VL - 7
SN - 0362-4803
SN - 1099-1344
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{1971_Ranzi,
author = {B M Ranzi and F. Ronchetti and G. Russo},
title = {Synthesis of 15α, 15β, 21, 21, 21−3H5-pregn-5-en-3β-ol-20-one},
journal = {Journal of Labelled Compounds and Radiopharmaceuticals},
year = {1971},
volume = {7},
publisher = {Wiley},
month = {oct},
url = {https://doi.org/10.1002/jlcr.2590070407},
number = {4},
pages = {431--439},
doi = {10.1002/jlcr.2590070407}
}
MLA
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MLA Copy
Ranzi, B. M., et al. “Synthesis of 15α, 15β, 21, 21, 21−3H5-pregn-5-en-3β-ol-20-one.” Journal of Labelled Compounds and Radiopharmaceuticals, vol. 7, no. 4, Oct. 1971, pp. 431-439. https://doi.org/10.1002/jlcr.2590070407.