Hydrolysis of Steroid Oximes: Mechanism and Products
1
Analytical Research Group, Division of Chemical Research, Ortho Research Foundation, Raritan, NJ 08869
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Publication type: Journal Article
Publication date: 1974-01-01
scimago Q1
wos Q2
SJR: 0.737
CiteScore: 7.2
Impact factor: 3.8
ISSN: 00223549, 15206017
PubMed ID:
4811289
Pharmaceutical Science
Abstract
The conversion of 17α-acetoxy-6αmethyl-4-pregnen-3,20-dione 3-oxime to the corresponding diketone in acidic media was found to be a first-order reaction at 37°. The effects of incorporating ester groupings at the oxime function or at the C-17 position and modifications in ring B were also investigated. Only the length of the ester chain at the oxime function had a profound effect on the rate constant. From these observations, it is proposed that two competing mechanisms of hydrolysis are involved for the oxime esters.
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GOST
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Huettemann R. E., Shroff A. P. Hydrolysis of Steroid Oximes: Mechanism and Products // Journal of Pharmaceutical Sciences. 1974. Vol. 63. No. 1. pp. 74-77.
GOST all authors (up to 50)
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Huettemann R. E., Shroff A. P. Hydrolysis of Steroid Oximes: Mechanism and Products // Journal of Pharmaceutical Sciences. 1974. Vol. 63. No. 1. pp. 74-77.
Cite this
RIS
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TY - JOUR
DO - 10.1002/jps.2600630118
UR - https://doi.org/10.1002/jps.2600630118
TI - Hydrolysis of Steroid Oximes: Mechanism and Products
T2 - Journal of Pharmaceutical Sciences
AU - Huettemann, Richard E
AU - Shroff, Arvin P
PY - 1974
DA - 1974/01/01
PB - Elsevier
SP - 74-77
IS - 1
VL - 63
PMID - 4811289
SN - 0022-3549
SN - 1520-6017
ER -
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BibTex (up to 50 authors)
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@article{1974_Huettemann,
author = {Richard E Huettemann and Arvin P Shroff},
title = {Hydrolysis of Steroid Oximes: Mechanism and Products},
journal = {Journal of Pharmaceutical Sciences},
year = {1974},
volume = {63},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1002/jps.2600630118},
number = {1},
pages = {74--77},
doi = {10.1002/jps.2600630118}
}
Cite this
MLA
Copy
Huettemann, Richard E., and Arvin P Shroff. “Hydrolysis of Steroid Oximes: Mechanism and Products.” Journal of Pharmaceutical Sciences, vol. 63, no. 1, Jan. 1974, pp. 74-77. https://doi.org/10.1002/jps.2600630118.