Analysis of drug contamination from parabens in theophylline olamine.
Publication type: Journal Article
Publication date: 1981-06-01
scimago Q1
wos Q2
SJR: 0.737
CiteScore: 7.2
Impact factor: 3.8
ISSN: 00223549, 15206017
PubMed ID:
7252796
Pharmaceutical Science
Abstract
Contaminants in a commercial enema sample of theophylline olamine were found to be derived from parabens and ethanolamine. These contaminants, whose presence was characterized by the loss of preservatives and solubilizing agent, were isolated directly from the drug sample and identified. A high-performance liquid chromatographic (HPLC) system was developed to separate completely and to measure quantitatively theophylline, the two impurities, 4-hydroxybenzoic acid and N-(2-hydroxyethyl)-4-hydroxybenzamide, and the remaining parabens. The material balance obtained from the results of quantitative HPLC indicated the formation of these impurities at the expense of parabens. TLC, IR, and UV spectrophotometry and NMR and mass spectrometric analyses were used for identification or for comparisons of the new compound and the known N-(2-hydroxyethyl)benzamide.
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GOST
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Juenge E. C., Gurka D. F., Kreienbaum M. A. Analysis of drug contamination from parabens in theophylline olamine. // Journal of Pharmaceutical Sciences. 1981. Vol. 70. No. 6. pp. 589-593.
GOST all authors (up to 50)
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Juenge E. C., Gurka D. F., Kreienbaum M. A. Analysis of drug contamination from parabens in theophylline olamine. // Journal of Pharmaceutical Sciences. 1981. Vol. 70. No. 6. pp. 589-593.
Cite this
RIS
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TY - JOUR
DO - 10.1002/jps.2600700603
UR - https://doi.org/10.1002/jps.2600700603
TI - Analysis of drug contamination from parabens in theophylline olamine.
T2 - Journal of Pharmaceutical Sciences
AU - Juenge, E C
AU - Gurka, D F
AU - Kreienbaum, M A
PY - 1981
DA - 1981/06/01
PB - Elsevier
SP - 589-593
IS - 6
VL - 70
PMID - 7252796
SN - 0022-3549
SN - 1520-6017
ER -
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BibTex (up to 50 authors)
Copy
@article{1981_Juenge,
author = {E C Juenge and D F Gurka and M A Kreienbaum},
title = {Analysis of drug contamination from parabens in theophylline olamine.},
journal = {Journal of Pharmaceutical Sciences},
year = {1981},
volume = {70},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1002/jps.2600700603},
number = {6},
pages = {589--593},
doi = {10.1002/jps.2600700603}
}
Cite this
MLA
Copy
Juenge, E. C., et al. “Analysis of drug contamination from parabens in theophylline olamine..” Journal of Pharmaceutical Sciences, vol. 70, no. 6, Jun. 1981, pp. 589-593. https://doi.org/10.1002/jps.2600700603.