Wiley
Prostate
,  volume 85 ,  issue 5 ,  pages 471-481

Time to Castration Resistance is Associated With Overall Survival Even After the Achievement of Castration Resistance in Metastatic Prostate Cancer

Hiroto Kato 1, 2
, 
Yusuke Goto 1, 2
, 
Satoko Kojima 1
, 
Yusuke Onoda 1
, 
Ken Wakai 1, 2
, 
Kyokushin Hou 1
, 
Kazuhiro Araki 1
, 
SHINICHI SAKAMOTO 2
, 
Tomohiko Ichikawa 2
, 
YUKIO NAYA 1
1
 
2
 
Publication type: Journal Article
Publication date: 2025-01-07
Wiley
scimago Q1
wos Q2
SJR: 1.071
CiteScore: 5.0
Impact factor: 2.5
ISSN: 02704137, 10970045
Abstract
ABSTRACT
Background

Recent clinical trials have shown that patients with metastatic castration‐sensitive prostate cancer in real‐world settings have different overall survival (OS) rates after stratifying for tumor burden or visceral metastasis. However, some patients with a low tumor burden and without visceral metastasis still have a poor survival. Androgen receptor signaling is still a main therapeutic target of prostate cancer treatment even after the achievement of castration resistance. In this regard, we hypothesized that time to castration resistance can be a prognostic factor of metastatic castration‐sensitive prostate cancer even after achieving castration resistance. The current study aimed to assess the novel prognostic factors, particularly time to castration resistance, of prostate cancer in patients at a real‐world single institution.

Methods

The data of 261 patients who were newly diagnosed with metastatic castration‐sensitive prostate cancer from January 2007 to December 2023 were retrospectively analyzed.

Results

The median OS was 60.7 months, and the median time to castration resistance was 13.1 months. Among 261 patients, 158 developed castration‐resistant prostate cancer. A shorter time to castration resistance, the presence of distant lymph node metastasis, ISUP grade group 5, and older age were associated with a shorter OS in patients who developed castration‐resistant prostate cancer. A shorter time to castration resistance was significantly associated with a shorter OS regardless of the tumor burden. Further, it was associated with a shorter OS even after the achievement of castration resistance.

Conclusions

The study results support the presence of persistent androgen receptor signaling even after achieving castration resistance in prostate cancer, and time to castration resistance can be a biomarker for the activation of androgen receptor signaling regardless of tumor burden.

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Kato H. et al. Time to Castration Resistance is Associated With Overall Survival Even After the Achievement of Castration Resistance in Metastatic Prostate Cancer // Prostate. 2025. Vol. 85. No. 5. pp. 471-481.
GOST all authors (up to 50) Copy
Kato H., Goto Y., Kojima S., Onoda Y., Wakai K., Hou K., Araki K., SAKAMOTO S., Ichikawa T., NAYA Y. Time to Castration Resistance is Associated With Overall Survival Even After the Achievement of Castration Resistance in Metastatic Prostate Cancer // Prostate. 2025. Vol. 85. No. 5. pp. 471-481.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1002/pros.24850
UR - https://onlinelibrary.wiley.com/doi/10.1002/pros.24850
TI - Time to Castration Resistance is Associated With Overall Survival Even After the Achievement of Castration Resistance in Metastatic Prostate Cancer
T2 - Prostate
AU - Kato, Hiroto
AU - Goto, Yusuke
AU - Kojima, Satoko
AU - Onoda, Yusuke
AU - Wakai, Ken
AU - Hou, Kyokushin
AU - Araki, Kazuhiro
AU - SAKAMOTO, SHINICHI
AU - Ichikawa, Tomohiko
AU - NAYA, YUKIO
PY - 2025
DA - 2025/01/07
PB - Wiley
SP - 471-481
IS - 5
VL - 85
SN - 0270-4137
SN - 1097-0045
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2025_Kato,
author = {Hiroto Kato and Yusuke Goto and Satoko Kojima and Yusuke Onoda and Ken Wakai and Kyokushin Hou and Kazuhiro Araki and SHINICHI SAKAMOTO and Tomohiko Ichikawa and YUKIO NAYA},
title = {Time to Castration Resistance is Associated With Overall Survival Even After the Achievement of Castration Resistance in Metastatic Prostate Cancer},
journal = {Prostate},
year = {2025},
volume = {85},
publisher = {Wiley},
month = {jan},
url = {https://onlinelibrary.wiley.com/doi/10.1002/pros.24850},
number = {5},
pages = {471--481},
doi = {10.1002/pros.24850}
}
MLA
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MLA Copy
Kato, Hiroto, et al. “Time to Castration Resistance is Associated With Overall Survival Even After the Achievement of Castration Resistance in Metastatic Prostate Cancer.” Prostate, vol. 85, no. 5, Jan. 2025, pp. 471-481. https://onlinelibrary.wiley.com/doi/10.1002/pros.24850.
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