Phytotherapy Research, volume 26, issue 9, pages 1418-1421
Astragalus membranaceus Ameliorates Reproductive Toxicity Induced by Cyclophosphamide in Male Mice
Publication type: Journal Article
Publication date: 2012-06-02
Journal:
Phytotherapy Research
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6.1
ISSN: 0951418X, 10991573
DOI:
10.1002/ptr.4756
Pharmacology
Abstract
The root of Astragalus membranaceus B(UNGE) (AM) is a medicinal herb that has been capable of reducing the adverse effects of conventional chemotherapy. To investigate the effects of AM on cyclophosphamide (CP)-induced reproductive toxicity in mouse testes, 5-week-old male imprinting control region mice were divided into five groups; CP was treated on the first day of each week for 5 weeks (100 mg/kg, i.p.), and AM was treated for 5 days a week for 5 weeks. At the end of the treatment period, the testes were taken out, cleared of the adhering tissues, and weighed. Epididymis was taken out and used for sperm analysis. Testis samples were frozen for real-time quantitative PCR and Western blot analysis. AM treatment increased diminished relative testes weight, and sperm count and motility in mice treated with CP. CP treatment has detrimental effects on the expression of cAMP-responsive element modulator (CREM), a transcription factor that is highly expressed in male germ cells and is crucial to post-meiotic germ cell differentiation. AM restored CREM at both the mRNA and protein levels. AM has beneficial influences and appears able to ameliorate relative testes weight, sperm parameters, and CREM expression against CP-induced reproductive toxicity.
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GOST
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Kim W. et al. Astragalus membranaceus Ameliorates Reproductive Toxicity Induced by Cyclophosphamide in Male Mice // Phytotherapy Research. 2012. Vol. 26. No. 9. pp. 1418-1421.
GOST all authors (up to 50)
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Kim W., Kim S. H., Park S., Chang M. S. Astragalus membranaceus Ameliorates Reproductive Toxicity Induced by Cyclophosphamide in Male Mice // Phytotherapy Research. 2012. Vol. 26. No. 9. pp. 1418-1421.
Cite this
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TY - JOUR
DO - 10.1002/ptr.4756
UR - https://doi.org/10.1002/ptr.4756
TI - Astragalus membranaceus Ameliorates Reproductive Toxicity Induced by Cyclophosphamide in Male Mice
T2 - Phytotherapy Research
AU - Kim, Woojin
AU - Kim, Sung Hoon
AU - Park, Seong-Kyu
AU - Chang, Mun Seog
PY - 2012
DA - 2012/06/02
PB - Wiley
SP - 1418-1421
IS - 9
VL - 26
SN - 0951-418X
SN - 1099-1573
ER -
Cite this
BibTex
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@article{2012_Kim,
author = {Woojin Kim and Sung Hoon Kim and Seong-Kyu Park and Mun Seog Chang},
title = {Astragalus membranaceus Ameliorates Reproductive Toxicity Induced by Cyclophosphamide in Male Mice},
journal = {Phytotherapy Research},
year = {2012},
volume = {26},
publisher = {Wiley},
month = {jun},
url = {https://doi.org/10.1002/ptr.4756},
number = {9},
pages = {1418--1421},
doi = {10.1002/ptr.4756}
}
Cite this
MLA
Copy
Kim, Woojin, et al. “Astragalus membranaceus Ameliorates Reproductive Toxicity Induced by Cyclophosphamide in Male Mice.” Phytotherapy Research, vol. 26, no. 9, Jun. 2012, pp. 1418-1421. https://doi.org/10.1002/ptr.4756.