5‐Styrylisoxazoles: π‐Conjugated System with Fluorescent Properties and Bioactivity
Publication type: Journal Article
Publication date: 2023-05-24
General Chemistry
Abstract
A simple two‐step protocol for the synthesis of 3‐aryl/hetaryl‐4‐nitro‐5‐styrylisoxazole was elaborated. A large series of novel 5‐styrylisoxazoles (36 compounds) containing various substituents at positions 3 and 5 of isoxazole cycle was obtained. The title compounds revealed fluorescent properties in visible region, possessing emission maximum up to 610nm. The effect of solvatochromism and chemosensor properties towards a number of metal cations were demonstrated. Cytotoxic activity against MCF‐7 (breast carcinoma), HCT‐116 (colon carcinoma), A549 (pulmonary carcinoma) and WI38 (fibroblasts from lung tissue) cell lines was tested and toxicity in the concentration range of 10–100 μM was found for several compounds.
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5
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5
Citations from 2024:
5
(100%)
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Sadovnikov K. S. et al. 5‐Styrylisoxazoles: π‐Conjugated System with Fluorescent Properties and Bioactivity // ChemistrySelect. 2023. Vol. 8. No. 20.
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Sadovnikov K. S., Vasilenko D. A., Gracheva Y. A., Grishin Y. K., Roznyatovsky V. A., Tafeenko V. A., Astakhova N. E., Burtsev I. D., Milaeva E. R., Averina E. B. 5‐Styrylisoxazoles: π‐Conjugated System with Fluorescent Properties and Bioactivity // ChemistrySelect. 2023. Vol. 8. No. 20.
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TY - JOUR
DO - 10.1002/slct.202300830
UR - https://doi.org/10.1002/slct.202300830
TI - 5‐Styrylisoxazoles: π‐Conjugated System with Fluorescent Properties and Bioactivity
T2 - ChemistrySelect
AU - Sadovnikov, Kirill S
AU - Vasilenko, Dmitry A.
AU - Gracheva, Yulia A.
AU - Grishin, Yuri K.
AU - Roznyatovsky, Vitaly A.
AU - Tafeenko, Victor A.
AU - Astakhova, Nadezhda E.
AU - Burtsev, Ivan D
AU - Milaeva, Elena R.
AU - Averina, E. B.
PY - 2023
DA - 2023/05/24
PB - Wiley
IS - 20
VL - 8
SN - 2365-6549
ER -
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@article{2023_Sadovnikov,
author = {Kirill S Sadovnikov and Dmitry A. Vasilenko and Yulia A. Gracheva and Yuri K. Grishin and Vitaly A. Roznyatovsky and Victor A. Tafeenko and Nadezhda E. Astakhova and Ivan D Burtsev and Elena R. Milaeva and E. B. Averina},
title = {5‐Styrylisoxazoles: π‐Conjugated System with Fluorescent Properties and Bioactivity},
journal = {ChemistrySelect},
year = {2023},
volume = {8},
publisher = {Wiley},
month = {may},
url = {https://doi.org/10.1002/slct.202300830},
number = {20},
doi = {10.1002/slct.202300830}
}