Wiley
ChemistrySelect
,  volume 10 ,  issue 16 ,  publication number e202501056

Synthetic Strategies for Cyclobutane Derivatives Without Employing [2 + 2] Cycloaddition and Their Application in Organic Synthesis

Ram C. Yadav* 1
, 
Md Firoj Hossain 2
, 
Subrata Ghosh 3
1
 
Department of Chemistry Faculty of Engineering & Technology VBS Purvanchal University Jaunpur Uttar Pradesh 222003 India | 
2
 
3
 
Publication type: Journal Article
Publication date: 2025-04-24
Wiley
scimago Q3
wos Q3
SJR: 0.366
CiteScore: 3.0
Impact factor: 2.0
ISSN: 23656549
Abstract

The cyclobutane ring stands as a remarkable structural motif, renowned for its presence in natural products and its unique reactivity in organic synthesis. Its inherent ring strain drives selective C─C bond cleavage and ring expansion, making it a compelling target for synthetic chemists. While [2 + 2] cycloaddition remains a classic method for cyclobutane construction, this approach is often unsuitable for intricately embedded cyclobutane moieties in complex natural products. To overcome these limitations, innovative synthetic strategies have been developed, bypassing direct cycloaddition to achieve precise and efficient cyclobutane assembly. This review highlights these methodologies and their transformative applications, expanding the synthetic repertoire for cyclobutane derivatives in organic chemistry.

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Yadav* R. C., Hossain M. F., Ghosh S. Synthetic Strategies for Cyclobutane Derivatives Without Employing [2 + 2] Cycloaddition and Their Application in Organic Synthesis // ChemistrySelect. 2025. Vol. 10. No. 16. e202501056
GOST all authors (up to 50) Copy
Yadav* R. C., Hossain M. F., Ghosh S. Synthetic Strategies for Cyclobutane Derivatives Without Employing [2 + 2] Cycloaddition and Their Application in Organic Synthesis // ChemistrySelect. 2025. Vol. 10. No. 16. e202501056
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TY - JOUR
DO - 10.1002/slct.202501056
UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202501056
TI - Synthetic Strategies for Cyclobutane Derivatives Without Employing [2 + 2] Cycloaddition and Their Application in Organic Synthesis
T2 - ChemistrySelect
AU - Yadav*, Ram C.
AU - Hossain, Md Firoj
AU - Ghosh, Subrata
PY - 2025
DA - 2025/04/24
PB - Wiley
IS - 16
VL - 10
SN - 2365-6549
ER -
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Cite this
BibTex (up to 50 authors) Copy
@article{2025_Yadav*,
author = {Ram C. Yadav* and Md Firoj Hossain and Subrata Ghosh},
title = {Synthetic Strategies for Cyclobutane Derivatives Without Employing [2 + 2] Cycloaddition and Their Application in Organic Synthesis},
journal = {ChemistrySelect},
year = {2025},
volume = {10},
publisher = {Wiley},
month = {apr},
url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202501056},
number = {16},
pages = {e202501056},
doi = {10.1002/slct.202501056}
}