Angewandte Chemie - International Edition, volume 37, issue 17, pages 2354-2359

Asymmetric Synthesis of Bryostatin 2

David A Evans ¹

Percy H. Carter ¹

Scott Miller ¹

Joëlle Prunet ¹

Andre Charette ¹

David A. Petrone ¹

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Department of Chemistry & Chemical Biology, Harvard University Cambridge, MA 02138 (USA), Fax: (+1) 617-495-1460 |

Publication type: Journal Article

Publication date: 1998-09-18

Wiley

Journal: Angewandte Chemie - International Edition

Quartile SCImago

Quartile WOS

Impact factor: 16.6

ISSN: 14337851, 15213773

DOI: 10.1002/(SICI)1521-3773(19980918)37:17<2354::AID-ANIE2354>3.0.CO;2-9

Copy DOI

General Chemistry

Catalysis

Abstract

The potent bryostatin antitumor agents are currently in phase II clinical trials for the treatment of a variety of forms of cancer. Aldol reactions and directed reductions are among the essential steps for the formation of fragments A–C in the total synthesis of the title compound. Coupling of these fragments by sulfone-based olefination and alkylation reactions was followed by macrocyclization and introduction of the enoate moieties on rings B and C.

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Organic Letters	Organic Letters, 9, 7.63% Organic Letters 9 publications, 7.63%
Angewandte Chemie - International Edition	Angewandte Chemie - International Edition, 9, 7.63% Angewandte Chemie - International Edition 9 publications, 7.63%
Journal of the American Chemical Society	Journal of the American Chemical Society, 8, 6.78% Journal of the American Chemical Society 8 publications, 6.78%
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Journal of Organic Chemistry	Journal of Organic Chemistry, 4, 3.39% Journal of Organic Chemistry 4 publications, 3.39%
Synlett	Synlett, 4, 3.39% Synlett 4 publications, 3.39%
Chemical Communications	Chemical Communications, 3, 2.54% Chemical Communications 3 publications, 2.54%
Israel Journal of Chemistry	Israel Journal of Chemistry, 2, 1.69% Israel Journal of Chemistry 2 publications, 1.69%
Bulletin of the Chemical Society of Japan	Bulletin of the Chemical Society of Japan, 1, 0.85% Bulletin of the Chemical Society of Japan 1 publication, 0.85%
Bioorganic and Medicinal Chemistry	Bioorganic and Medicinal Chemistry, 1, 0.85% Bioorganic and Medicinal Chemistry 1 publication, 0.85%
Inorganica Chimica Acta	Inorganica Chimica Acta, 1, 0.85% Inorganica Chimica Acta 1 publication, 0.85%
Collection of Czechoslovak Chemical Communications	Collection of Czechoslovak Chemical Communications, 1, 0.85% Collection of Czechoslovak Chemical Communications 1 publication, 0.85%
Phytochemistry Reviews	Phytochemistry Reviews, 1, 0.85% Phytochemistry Reviews 1 publication, 0.85%
Chinese Chemical Letters	Chinese Chemical Letters, 1, 0.85% Chinese Chemical Letters 1 publication, 0.85%
Medicinal Research Reviews	Medicinal Research Reviews, 1, 0.85% Medicinal Research Reviews 1 publication, 0.85%
ChemBioChem	ChemBioChem, 1, 0.85% ChemBioChem 1 publication, 0.85%
ChemistrySelect	ChemistrySelect, 1, 0.85% ChemistrySelect 1 publication, 0.85%
Advanced Synthesis and Catalysis	Advanced Synthesis and Catalysis, 1, 0.85% Advanced Synthesis and Catalysis 1 publication, 0.85%
Chemistry - An Asian Journal	Chemistry - An Asian Journal, 1, 0.85% Chemistry - An Asian Journal 1 publication, 0.85%
ChemInform	ChemInform, 1, 0.85% ChemInform 1 publication, 0.85%
Accounts of Chemical Research	Accounts of Chemical Research, 1, 0.85% Accounts of Chemical Research 1 publication, 0.85%
Chemical Reviews	Chemical Reviews, 1, 0.85% Chemical Reviews 1 publication, 0.85%
Natural Product Reports	Natural Product Reports, 1, 0.85% Natural Product Reports 1 publication, 0.85%
Russian Journal of Organic Chemistry	Russian Journal of Organic Chemistry, 1, 0.85% Russian Journal of Organic Chemistry 1 publication, 0.85%
Lipophilicity in Drug Action and Toxicology	Lipophilicity in Drug Action and Toxicology, 1, 0.85% Lipophilicity in Drug Action and Toxicology 1 publication, 0.85%
	2 4 6 8 10 12 14

Citations by publishers

	5 10 15 20 25 30 35 40
Wiley	Wiley, 37, 31.36% Wiley 37 publications, 31.36%
Elsevier	Elsevier, 29, 24.58% Elsevier 29 publications, 24.58%
American Chemical Society (ACS)	American Chemical Society (ACS), 23, 19.49% American Chemical Society (ACS) 23 publications, 19.49%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 5, 4.24% Royal Society of Chemistry (RSC) 5 publications, 4.24%
Thieme	Thieme, 5, 4.24% Thieme 5 publications, 4.24%
Springer Nature	Springer Nature, 2, 1.69% Springer Nature 2 publications, 1.69%
The Chemical Society of Japan	The Chemical Society of Japan, 1, 0.85% The Chemical Society of Japan 1 publication, 0.85%
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences	Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 1, 0.85% Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences 1 publication, 0.85%
Pleiades Publishing	Pleiades Publishing, 1, 0.85% Pleiades Publishing 1 publication, 0.85%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 0.85% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 0.85%
	5 10 15 20 25 30 35 40

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Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
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Evans D. A. et al. Asymmetric Synthesis of Bryostatin 2 // Angewandte Chemie - International Edition. 1998. Vol. 37. No. 17. pp. 2354-2359.

GOST all authors (up to 50) Copy

Evans D. A., Carter P. H., Miller S., Prunet J., Charette A., Petrone D. A. Asymmetric Synthesis of Bryostatin 2 // Angewandte Chemie - International Edition. 1998. Vol. 37. No. 17. pp. 2354-2359.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1002/(SICI)1521-3773(19980918)37:17<2354::AID-ANIE2354>3.0.CO;2-9

UR - https://doi.org/10.1002/(SICI)1521-3773(19980918)37:17<2354::AID-ANIE2354>3.0.CO;2-9

TI - Asymmetric Synthesis of Bryostatin 2

T2 - Angewandte Chemie - International Edition

AU - Evans, David A

AU - Carter, Percy H.

AU - Miller, Scott

AU - Prunet, Joëlle

AU - Charette, Andre

AU - Petrone, David A.

PY - 1998

DA - 1998/09/18 00:00:00

PB - Wiley

SP - 2354-2359

IS - 17

VL - 37

SN - 1433-7851

SN - 1521-3773

ER -

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BibTex Copy

@article{1998_Evans,

author = {David A Evans and Percy H. Carter and Scott Miller and Joëlle Prunet and Andre Charette and David A. Petrone},

title = {Asymmetric Synthesis of Bryostatin 2},

journal = {Angewandte Chemie - International Edition},

year = {1998},

volume = {37},

publisher = {Wiley},

month = {sep},

url = {https://doi.org/10.1002/(SICI)1521-3773(19980918)37:17<2354::AID-ANIE2354>3.0.CO;2-9},

number = {17},

pages = {2354--2359},

doi = {10.1002/(SICI)1521-3773(19980918)37:17<2354::AID-ANIE2354>3.0.CO;2-9}

}

MLA

Cite this

MLA Copy

Evans, David A., et al. “Asymmetric Synthesis of Bryostatin 2.” Angewandte Chemie - International Edition, vol. 37, no. 17, Sep. 1998, pp. 2354-2359. https://doi.org/10.1002/(SICI)1521-3773(19980918)37:17<2354::AID-ANIE2354>3.0.CO;2-9.

Found error?

Publisher

Wiley

Journal

Angewandte Chemie - International Edition

Quartile SCImago

Quartile WOS

Impact factor

16.6

ISSN

14337851 (Print)
15213773 (Electronic)