Advanced healthcare materials, volume 10, issue 20, pages 2100955

Sensing Inflammation Biomarkers with Electrolyte‐Gated Organic Electronic Transistors

Bernhard Burtscher 1
Pamela Allison Manco Urbina 2
Chiara Diacci 1
Simone Borghi 2
Carlo Salvarani 4
Magnus Berggren 1
F. Biscarini 2, 5
Daniel Simon 1
Carlo Bortolotti 2
Publication typeJournal Article
Publication date2021-08-22
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor10
ISSN21922640, 21922659
Pharmaceutical Science
Biomaterials
Biomedical Engineering
Abstract
An overview of cytokine biosensing is provided, with a focus on the opportunities provided by organic electronic platforms for monitoring these inflammation biomarkers which manifest at ultralow concentration levels in physiopathological conditions. Specifically, two of the field's state-of-the-art technologies-organic electrochemical transistors (OECTs) and electrolyte gated organic field effect transistors (EGOFETs)-and their use in sensing cytokines and other proteins associated with inflammation are a particular focus. The overview will include an introduction to current clinical and "gold standard" quantification techniques and their limitations in terms of cost, time, and required infrastructure. A critical review of recent progress with OECT- and EGOFET-based protein biosensors is presented, alongside a discussion onthe future of these technologies in the years and decades ahead. This is especially timely as the world grapples with limited healthcare diagnostics during the Coronavirus disease (COVID-19)pandemic where one of the worst-case scenarios for patients is the "cytokine storm." Clearly, low-cost point-of-care technologies provided by OECTs and EGOFETs can ease the global burden on healthcare systems and support professionals by providing unprecedented wealth of data that can help to monitor disease progression in real time.

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Burtscher B. et al. Sensing Inflammation Biomarkers with Electrolyte‐Gated Organic Electronic Transistors // Advanced healthcare materials. 2021. Vol. 10. No. 20. p. 2100955.
GOST all authors (up to 50) Copy
Burtscher B., Manco Urbina P. A., Diacci C., Borghi S., Pinti M., Cossarizza A., Salvarani C., Berggren M., Biscarini F., Simon D., Bortolotti C. Sensing Inflammation Biomarkers with Electrolyte‐Gated Organic Electronic Transistors // Advanced healthcare materials. 2021. Vol. 10. No. 20. p. 2100955.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1002/adhm.202100955
UR - https://doi.org/10.1002/adhm.202100955
TI - Sensing Inflammation Biomarkers with Electrolyte‐Gated Organic Electronic Transistors
T2 - Advanced healthcare materials
AU - Borghi, Simone
AU - Burtscher, Bernhard
AU - Manco Urbina, Pamela Allison
AU - Diacci, Chiara
AU - Pinti, Marcello
AU - Cossarizza, Andrea
AU - Berggren, Magnus
AU - Biscarini, F.
AU - Simon, Daniel
AU - Bortolotti, Carlo
AU - Salvarani, Carlo
PY - 2021
DA - 2021/08/22 00:00:00
PB - Wiley
SP - 2100955
IS - 20
VL - 10
SN - 2192-2640
SN - 2192-2659
ER -
BibTex |
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BibTex Copy
@article{2021_Burtscher,
author = {Simone Borghi and Bernhard Burtscher and Pamela Allison Manco Urbina and Chiara Diacci and Marcello Pinti and Andrea Cossarizza and Magnus Berggren and F. Biscarini and Daniel Simon and Carlo Bortolotti and Carlo Salvarani},
title = {Sensing Inflammation Biomarkers with Electrolyte‐Gated Organic Electronic Transistors},
journal = {Advanced healthcare materials},
year = {2021},
volume = {10},
publisher = {Wiley},
month = {aug},
url = {https://doi.org/10.1002/adhm.202100955},
number = {20},
pages = {2100955},
doi = {10.1002/adhm.202100955}
}
MLA
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MLA Copy
Burtscher, Bernhard, et al. “Sensing Inflammation Biomarkers with Electrolyte‐Gated Organic Electronic Transistors.” Advanced healthcare materials, vol. 10, no. 20, Aug. 2021, p. 2100955. https://doi.org/10.1002/adhm.202100955.
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