Advanced Materials

, volume 25 , issue 34 , pages 4718-4722

Novel Conjugation of Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand (TRAIL) with Monomethyl Auristatin E for Efficient Antitumor Drug Delivery

Li Qiang Pan ¹

Hai-Bin Wang ¹

Zhang Ming Xie ¹

Zhao-Hui Li ¹

Xiao-jing Tang ¹

Yingchun Xu ¹

Chen Zhang ¹

Hua Naranmandura ¹

Shu-Qing Chen ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Department of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China |

Publication type: Journal Article

Publication date: 2013-07-12

Wiley

Advanced Materials

scimago Q1

wos Q1

SJR: 8.851

CiteScore: 39.4

Impact factor: 26.8

ISSN: 09359648, 15214095

DOI: 10.1002/adma.201301385

Copy DOI

PubMed ID: 23847045

General Materials Science

Mechanical Engineering

Mechanics of Materials

Abstract

Monomethyl auristatin E (MMAE) is conjugated with TNF-related apoptosis-inducing ligand (TRAIL) via a linker that is stable in extracellular fluid, while it is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic mechanism of MMAE. The TRAIL-MMAE conjugate is a conceptually viable therapeutic strategy with improved in vitro antitumor activity, cell circle arrest and specific accumulation in tumor to treat TRAIL-resistant tumors.

Found

1 citation

Yagolovich Anne

🥼 🤝

PhD in Biological/biomedical sciences, lecturer

31 publications, 267 citations, 4 reviews

h-index: 10

Lomonosov Moscow State University

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Research interests

Apoptosis

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GOST |

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GOST Copy

Pan L. Q. et al. Novel Conjugation of Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand (TRAIL) with Monomethyl Auristatin E for Efficient Antitumor Drug Delivery // Advanced Materials. 2013. Vol. 25. No. 34. pp. 4718-4722.

GOST all authors (up to 50) Copy

Pan L. Q., Wang H., Xie Z. M., Li Z., Tang X., Xu Y., Zhang C., Naranmandura H., Chen S. Novel Conjugation of Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand (TRAIL) with Monomethyl Auristatin E for Efficient Antitumor Drug Delivery // Advanced Materials. 2013. Vol. 25. No. 34. pp. 4718-4722.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1002/adma.201301385

UR - https://doi.org/10.1002/adma.201301385

TI - Novel Conjugation of Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand (TRAIL) with Monomethyl Auristatin E for Efficient Antitumor Drug Delivery

T2 - Advanced Materials

AU - Pan, Li Qiang

AU - Wang, Hai-Bin

AU - Xie, Zhang Ming

AU - Li, Zhao-Hui

AU - Tang, Xiao-jing

AU - Xu, Yingchun

AU - Zhang, Chen

AU - Naranmandura, Hua

AU - Chen, Shu-Qing

PY - 2013

DA - 2013/07/12

PB - Wiley

SP - 4718-4722

IS - 34

VL - 25

PMID - 23847045

SN - 0935-9648

SN - 1521-4095

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2013_Pan,

author = {Li Qiang Pan and Hai-Bin Wang and Zhang Ming Xie and Zhao-Hui Li and Xiao-jing Tang and Yingchun Xu and Chen Zhang and Hua Naranmandura and Shu-Qing Chen},

title = {Novel Conjugation of Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand (TRAIL) with Monomethyl Auristatin E for Efficient Antitumor Drug Delivery},

journal = {Advanced Materials},

year = {2013},

volume = {25},

publisher = {Wiley},

month = {jul},

url = {https://doi.org/10.1002/adma.201301385},

number = {34},

pages = {4718--4722},

doi = {10.1002/adma.201301385}

}

MLA

Cite this

MLA Copy

Pan, Li Qiang, et al. “Novel Conjugation of Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand (TRAIL) with Monomethyl Auristatin E for Efficient Antitumor Drug Delivery.” Advanced Materials, vol. 25, no. 34, Jul. 2013, pp. 4718-4722. https://doi.org/10.1002/adma.201301385.

Publisher

Wiley

Journal

Advanced Materials

scimago Q1

wos Q1

SJR

8.851

CiteScore

39.4

Impact factor

26.8

ISSN

09359648 (Print)

15214095 (Electronic)