Advanced Materials

, том 25 , издание 34 , страницы 4718-4722

Novel Conjugation of Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand (TRAIL) with Monomethyl Auristatin E for Efficient Antitumor Drug Delivery

Тип публикации: Journal Article

Дата публикации: 2013-07-12

Wiley

Advanced Materials

scimago Q1

wos Q1

БС1

SJR: 8.851

CiteScore: 39.4

Impact factor: 26.8

ISSN: 09359648, 15214095

DOI: 10.1002/adma.201301385

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PubMed ID: 23847045

General Materials Science

Mechanical Engineering

Mechanics of Materials

Краткое описание

Monomethyl auristatin E (MMAE) is conjugated with TNF-related apoptosis-inducing ligand (TRAIL) via a linker that is stable in extracellular fluid, while it is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic mechanism of MMAE. The TRAIL-MMAE conjugate is a conceptually viable therapeutic strategy with improved in vitro antitumor activity, cell circle arrest and specific accumulation in tumor to treat TRAIL-resistant tumors.

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Московский государственный университет имени М.В. Ломоносова

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Pan L. Q. et al. Novel Conjugation of Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand (TRAIL) with Monomethyl Auristatin E for Efficient Antitumor Drug Delivery // Advanced Materials. 2013. Vol. 25. No. 34. pp. 4718-4722.

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Pan L. Q., Wang H., Xie Z. M., Li Z., Tang X., Xu Y., Zhang C., Naranmandura H., Chen S. Novel Conjugation of Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand (TRAIL) with Monomethyl Auristatin E for Efficient Antitumor Drug Delivery // Advanced Materials. 2013. Vol. 25. No. 34. pp. 4718-4722.

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TY - JOUR

DO - 10.1002/adma.201301385

UR - https://doi.org/10.1002/adma.201301385

TI - Novel Conjugation of Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand (TRAIL) with Monomethyl Auristatin E for Efficient Antitumor Drug Delivery

T2 - Advanced Materials

AU - Pan, Li Qiang

AU - Wang, Hai-Bin

AU - Xie, Zhang Ming

AU - Li, Zhao-Hui

AU - Tang, Xiao-jing

AU - Xu, Yingchun

AU - Zhang, Chen

AU - Naranmandura, Hua

AU - Chen, Shu-Qing

PY - 2013

DA - 2013/07/12

PB - Wiley

SP - 4718-4722

IS - 34

VL - 25

PMID - 23847045

SN - 0935-9648

SN - 1521-4095

ER -

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@article{2013_Pan,

author = {Li Qiang Pan and Hai-Bin Wang and Zhang Ming Xie and Zhao-Hui Li and Xiao-jing Tang and Yingchun Xu and Chen Zhang and Hua Naranmandura and Shu-Qing Chen},

title = {Novel Conjugation of Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand (TRAIL) with Monomethyl Auristatin E for Efficient Antitumor Drug Delivery},

journal = {Advanced Materials},

year = {2013},

volume = {25},

publisher = {Wiley},

month = {jul},

url = {https://doi.org/10.1002/adma.201301385},

number = {34},

pages = {4718--4722},

doi = {10.1002/adma.201301385}

}

MLA

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MLA Скопировать

Pan, Li Qiang, et al. “Novel Conjugation of Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand (TRAIL) with Monomethyl Auristatin E for Efficient Antitumor Drug Delivery.” Advanced Materials, vol. 25, no. 34, Jul. 2013, pp. 4718-4722. https://doi.org/10.1002/adma.201301385.

Издатель

Wiley

Журнал

Advanced Materials

scimago Q1

wos Q1

БС1

SJR

8.851

CiteScore

39.4

Impact factor

26.8

ISSN

09359648 (Print)

15214095 (Electronic)