Advanced Materials, volume 35, issue 42
Single‐Molecule Bioelectronic Portable Array for Early‐Diagnosis of Pancreatic Cancer Precursors
Enrico Genco
1
,
Francesco Modena
2, 3
,
Lucia Sarcina
4
,
Kim Björkström
5
,
Celestino Brunetti
6
,
Mario Caironi
2
,
Mariapia Caputo
7
,
Virginia Maria Demartis
8
,
Cinzia Di Franco
9
,
Giulia Frusconi
8
,
Lena Haeberle
10
,
Piero Larizza
6
,
Maria Teresa Mancini
6
,
Ronald Österbacka
5
,
William Reeves
11
,
Gaetano Scamarcio
9, 12
,
Cecilia Scandurra
4
,
May Wheeler
11
,
Eugenio Cantatore
1
,
Irene Esposito
10
,
Eleonora Macchia
5, 7
,
Fabrizio Torricelli
8
,
Fabrizio Antonio Viola
2
,
L. Torsi
4
6
Masmec Biomed – Masmec SpA division Modugno (BA) 70026 Italy
|
11
FlexEnable Technology Ltd Cambridge CB4 0FX UK
|
Publication type: Journal Article
Publication date: 2023-08-31
Journal:
Advanced Materials
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 29.4
ISSN: 09359648, 15214095
General Materials Science
Mechanical Engineering
Mechanics of Materials
Abstract
A cohort of 47 patients is screened for pancreatic cancer precursors with a portable 96‐well bioelectronic sensing‐array for single‐molecule assay in cysts fluid and blood plasma, deployable at point‐of‐care (POC). Pancreatic cancer precursors are mucinous cysts diagnosed with a sensitivity of at most 80% by state‐of‐the‐art cytopathological molecular analyses (e.g., KRASmut DNA). Adding the simultaneous assay of proteins related to malignant transformation (e.g., MUC1 and CD55) is deemed essential to enhance diagnostic accuracy. The bioelectronic array proposed here, based on single‐molecule‐with‐a‐large‐transistor (SiMoT) technology, can assay both nucleic acids and proteins at the single‐molecule limit‐of‐identification (LOI) (1% of false‐positives and false‐negatives). It comprises an enzyme‐linked immunosorbent assay (ELISA)‐like 8 × 12‐array organic‐electronics disposable cartridge with an electrolyte‐gated organic transistor sensor array, and a reusable reader, integrating a custom Si‐IC chip, operating via software installed on a USB‐connected smart device. The cartridge is complemented by a 3D‐printed sensing gate cover plate. KRASmut, MUC1, and CD55 biomarkers either in plasma or cysts‐fluid from 5 to 6 patients at a time, are multiplexed at single‐molecule LOI in 1.5 h. The pancreatic cancer precursors are classified via a machine‐learning analysis resulting in at least 96% diagnostic‐sensitivity and 100% diagnostic‐specificity. This preliminary study opens the way to POC liquid‐biopsy‐based early diagnosis of pancreatic‐cancer precursors in plasma.
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Genco E. et al. Single‐Molecule Bioelectronic Portable Array for Early‐Diagnosis of Pancreatic Cancer Precursors // Advanced Materials. 2023. Vol. 35. No. 42.
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Genco E., Modena F., Sarcina L., Björkström K., Brunetti C., Caironi M., Caputo M., Demartis V. M., Di Franco C., Frusconi G., Haeberle L., Larizza P., Mancini M. T., Österbacka R., Reeves W., Scamarcio G., Scandurra C., Wheeler M., Cantatore E., Esposito I., Macchia E., Torricelli F., Viola F. A., Torsi L. Single‐Molecule Bioelectronic Portable Array for Early‐Diagnosis of Pancreatic Cancer Precursors // Advanced Materials. 2023. Vol. 35. No. 42.
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TY - JOUR
DO - 10.1002/adma.202304102
UR - https://doi.org/10.1002/adma.202304102
TI - Single‐Molecule Bioelectronic Portable Array for Early‐Diagnosis of Pancreatic Cancer Precursors
T2 - Advanced Materials
AU - Genco, Enrico
AU - Modena, Francesco
AU - Sarcina, Lucia
AU - Björkström, Kim
AU - Brunetti, Celestino
AU - Caironi, Mario
AU - Caputo, Mariapia
AU - Demartis, Virginia Maria
AU - Di Franco, Cinzia
AU - Frusconi, Giulia
AU - Haeberle, Lena
AU - Larizza, Piero
AU - Mancini, Maria Teresa
AU - Österbacka, Ronald
AU - Reeves, William
AU - Scamarcio, Gaetano
AU - Scandurra, Cecilia
AU - Wheeler, May
AU - Cantatore, Eugenio
AU - Esposito, Irene
AU - Macchia, Eleonora
AU - Torricelli, Fabrizio
AU - Viola, Fabrizio Antonio
AU - Torsi, L.
PY - 2023
DA - 2023/08/31 00:00:00
PB - Wiley
IS - 42
VL - 35
SN - 0935-9648
SN - 1521-4095
ER -
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@article{2023_Genco,
author = {Enrico Genco and Francesco Modena and Lucia Sarcina and Kim Björkström and Celestino Brunetti and Mario Caironi and Mariapia Caputo and Virginia Maria Demartis and Cinzia Di Franco and Giulia Frusconi and Lena Haeberle and Piero Larizza and Maria Teresa Mancini and Ronald Österbacka and William Reeves and Gaetano Scamarcio and Cecilia Scandurra and May Wheeler and Eugenio Cantatore and Irene Esposito and Eleonora Macchia and Fabrizio Torricelli and Fabrizio Antonio Viola and L. Torsi},
title = {Single‐Molecule Bioelectronic Portable Array for Early‐Diagnosis of Pancreatic Cancer Precursors},
journal = {Advanced Materials},
year = {2023},
volume = {35},
publisher = {Wiley},
month = {aug},
url = {https://doi.org/10.1002/adma.202304102},
number = {42},
doi = {10.1002/adma.202304102}
}