Open Access
Advanced Materials Interfaces, volume 9, issue 11, pages 2102341
Detection of Neurofilament Light Chain with Label‐Free Electrolyte‐Gated Organic Field‐Effect Transistors
Kateryna Solodka
1
,
Marcello Berto
1
,
Diana Ferraro
2
,
Claudia Menozzi
3
,
Marco Borsari
4
,
Carlo Bortolotti
1
,
F. Biscarini
1, 5
,
1
Publication type: Journal Article
Publication date: 2022-02-10
Journal:
Advanced Materials Interfaces
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 5.4
ISSN: 21967350, 21967350
Mechanical Engineering
Mechanics of Materials
Abstract
Neurofilaments are structural scaffolding proteins of the neuronal cytoskeleton. Upon axonal injury, the neurofilament light chain (NF-L) is released into the interstitial fluid and eventually reaches the cerebrospinal fluid and blood. Therefore, NF-L is emerging as a biomarker of neurological disorders, including neurodegenerative dementia, Parkinson's disease, and multiple sclerosis. It is challenging to quantify NF-L in bodily fluids due to its low levels. This work reports the detection of NF-L in aqueous solutions with an organic electronic device. The biosensor is based on the electrolyte-gated organic field-effect transistor (EGOFET) architecture and can quantify NF-L down to sub-pM levels; thanks to modification of the device gate with anti-NF-L antibodies imparted with potentially controlled orientation. The response is fitted to the Guggenheim–Anderson–De Boer adsorption model to describe NF-L adsorption at the gate/electrolyte interface, to consider the formation of a strongly adsorbed protein layer bound to the antibody and the formation of weakly bound NF-L multilayers, an interpretation which is also backed up by morphological characterization via atomic force microscopy. The label-free, selective, and rapid response makes this EGOFET biosensor a promising tool for the diagnosis and monitoring of neuronal damages through the detection of NF-L in physio-pathological ranges.
Top-30
Citations by journals
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2
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Advanced Materials
2 publications, 18.18%
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Journal of Materials Chemistry C
2 publications, 18.18%
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Micromachines
1 publication, 9.09%
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Cellular and Molecular Neurobiology
1 publication, 9.09%
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Sensors and Actuators, B: Chemical
1 publication, 9.09%
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Advanced Functional Materials
1 publication, 9.09%
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Russian Chemical Reviews
1 publication, 9.09%
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Biosensors and Bioelectronics
1 publication, 9.09%
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2
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Citations by publishers
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1
2
3
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Wiley
3 publications, 27.27%
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Royal Society of Chemistry (RSC)
2 publications, 18.18%
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Elsevier
2 publications, 18.18%
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 9.09%
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Springer Nature
1 publication, 9.09%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 9.09%
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1
2
3
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Solodka K. et al. Detection of Neurofilament Light Chain with Label‐Free Electrolyte‐Gated Organic Field‐Effect Transistors // Advanced Materials Interfaces. 2022. Vol. 9. No. 11. p. 2102341.
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Solodka K., Berto M., Ferraro D., Menozzi C., Borsari M., Bortolotti C., Biscarini F., Pinti M. Detection of Neurofilament Light Chain with Label‐Free Electrolyte‐Gated Organic Field‐Effect Transistors // Advanced Materials Interfaces. 2022. Vol. 9. No. 11. p. 2102341.
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TY - JOUR
DO - 10.1002/admi.202102341
UR - https://doi.org/10.1002/admi.202102341
TI - Detection of Neurofilament Light Chain with Label‐Free Electrolyte‐Gated Organic Field‐Effect Transistors
T2 - Advanced Materials Interfaces
AU - Solodka, Kateryna
AU - Menozzi, Claudia
AU - Berto, Marcello
AU - Bortolotti, Carlo
AU - Biscarini, F.
AU - Ferraro, Diana
AU - Borsari, Marco
AU - Pinti, Marcello
PY - 2022
DA - 2022/02/10 00:00:00
PB - Wiley
SP - 2102341
IS - 11
VL - 9
SN - 2196-7350
SN - 2196-7350
ER -
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@article{2022_Solodka,
author = {Kateryna Solodka and Claudia Menozzi and Marcello Berto and Carlo Bortolotti and F. Biscarini and Diana Ferraro and Marco Borsari and Marcello Pinti},
title = {Detection of Neurofilament Light Chain with Label‐Free Electrolyte‐Gated Organic Field‐Effect Transistors},
journal = {Advanced Materials Interfaces},
year = {2022},
volume = {9},
publisher = {Wiley},
month = {feb},
url = {https://doi.org/10.1002/admi.202102341},
number = {11},
pages = {2102341},
doi = {10.1002/admi.202102341}
}
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Solodka, Kateryna, et al. “Detection of Neurofilament Light Chain with Label‐Free Electrolyte‐Gated Organic Field‐Effect Transistors.” Advanced Materials Interfaces, vol. 9, no. 11, Feb. 2022, p. 2102341. https://doi.org/10.1002/admi.202102341.