Open Access
Single‐Molecule Bioelectronic Label‐Free Assay of both Protein and Genomic Markers of Pancreatic Mucinous Cysts’ in Whole Blood Serum
Eleonora Macchia
1
,
Lucia Sarcina
2
,
Caroline Driescher
3
,
Zahra Gounani
1
,
Amit Tewari
1
,
Ronald Osterbacka
1
,
Gerardo Palazzo
2, 4
,
Angelo Tricase
2
,
Zsolt Miklos Kovacs Vajna
5
,
Fabrizio Antonio Viola
6
,
Francesco Modena
6, 7
,
Mario Caironi
6
,
Fabrizio Torricelli
5
,
I Esposito
3
,
L. Torsi
1, 2, 4
4
Publication type: Journal Article
Publication date: 2021-06-19
scimago Q1
wos Q1
SJR: 1.478
CiteScore: 10.7
Impact factor: 5.3
ISSN: 2199160X
Electronic, Optical and Magnetic Materials
Abstract
The timely diagnosis of cystic pancreatic cancer precursors is of utmost importance to improve patients’ low survival rate. Fine-needle aspiration cytology is endowed with low diagnostic sensitivity, while more effective is the assay of markers, such as a mutated KRAS, in the cyst fluids. Next-generation sequencing, detecting down to a single copy of a genomic marker, enables early diagnosis but the diagnostic sensitivity of high-grade cysts, likely to become malignant, is low. Assaying both mutated KRAS and MUC1 protein markers can improve diagnostic accuracy. Their detection in blood would also be minimally invasive. Here, the mucinous lesions markers, KRAS and MUC1, are both successfully assayed in blood serum at the physical limit with the label-free “Single-Molecule assay with a large Transistor—SiMoT.” This is a compelling proof of principle that the SiMoT platform holds high potential to enable a timely, minimally invasive, and accurate diagnosis of pancreatic cancer precursor cysts.
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29
Total citations:
29
Citations from 2024:
9
(31.03%)
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MLA
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GOST
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Macchia E. et al. Single‐Molecule Bioelectronic Label‐Free Assay of both Protein and Genomic Markers of Pancreatic Mucinous Cysts’ in Whole Blood Serum // Advanced Electronic Materials. 2021. Vol. 7. No. 9. p. 2100304.
GOST all authors (up to 50)
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Macchia E., Sarcina L., Driescher C., Gounani Z., Tewari A., Osterbacka R., Palazzo G., Tricase A., Kovacs Vajna Z. M., Viola F. A., Modena F., Caironi M., Torricelli F., Esposito I., Torsi L. Single‐Molecule Bioelectronic Label‐Free Assay of both Protein and Genomic Markers of Pancreatic Mucinous Cysts’ in Whole Blood Serum // Advanced Electronic Materials. 2021. Vol. 7. No. 9. p. 2100304.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/aelm.202100304
UR - https://doi.org/10.1002/aelm.202100304
TI - Single‐Molecule Bioelectronic Label‐Free Assay of both Protein and Genomic Markers of Pancreatic Mucinous Cysts’ in Whole Blood Serum
T2 - Advanced Electronic Materials
AU - Macchia, Eleonora
AU - Sarcina, Lucia
AU - Driescher, Caroline
AU - Gounani, Zahra
AU - Tewari, Amit
AU - Osterbacka, Ronald
AU - Palazzo, Gerardo
AU - Tricase, Angelo
AU - Kovacs Vajna, Zsolt Miklos
AU - Viola, Fabrizio Antonio
AU - Modena, Francesco
AU - Caironi, Mario
AU - Torricelli, Fabrizio
AU - Esposito, I
AU - Torsi, L.
PY - 2021
DA - 2021/06/19
PB - Wiley
SP - 2100304
IS - 9
VL - 7
SN - 2199-160X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Macchia,
author = {Eleonora Macchia and Lucia Sarcina and Caroline Driescher and Zahra Gounani and Amit Tewari and Ronald Osterbacka and Gerardo Palazzo and Angelo Tricase and Zsolt Miklos Kovacs Vajna and Fabrizio Antonio Viola and Francesco Modena and Mario Caironi and Fabrizio Torricelli and I Esposito and L. Torsi},
title = {Single‐Molecule Bioelectronic Label‐Free Assay of both Protein and Genomic Markers of Pancreatic Mucinous Cysts’ in Whole Blood Serum},
journal = {Advanced Electronic Materials},
year = {2021},
volume = {7},
publisher = {Wiley},
month = {jun},
url = {https://doi.org/10.1002/aelm.202100304},
number = {9},
pages = {2100304},
doi = {10.1002/aelm.202100304}
}
Cite this
MLA
Copy
Macchia, Eleonora, et al. “Single‐Molecule Bioelectronic Label‐Free Assay of both Protein and Genomic Markers of Pancreatic Mucinous Cysts’ in Whole Blood Serum.” Advanced Electronic Materials, vol. 7, no. 9, Jun. 2021, p. 2100304. https://doi.org/10.1002/aelm.202100304.