Open Access
Advanced Electronic Materials, volume 8, issue 9, pages 2200142
Robust Microfluidic Integrated Electrolyte‐Gated Organic Field‐Effect Transistor Sensors for Rapid, In Situ and Label‐Free Monitoring of DNA Hybridization
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Publication type: Journal Article
Publication date: 2022-05-31
Journal:
Advanced Electronic Materials
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6.2
ISSN: 2199160X, 2199160X
Electronic, Optical and Magnetic Materials
Abstract
Electrolyte-gated organic field-effect transistors (EGOFETs) are subject to intense research for biosensing in fluids. The ability of these devices to quantify a variety of chemical and biological molecules sensitively and selectively, but ex situ, has been widely demonstrated. However, continuous monitoring of analyte-receptor interactions in real time by EGOFETs, in high demand for practical applications, has rarely been explored. Here, an EGOFET array integrated with a microfluidic device, for real-time detection of the hybridization of DNA is presented. The integrated devices exhibit highly reproducible electrical performance in the array and can operate under different electrical stresses over >1 h with 85–96% figures of merit retention. The utility of the devices is demonstrated to detect the hybridization of a complementary target DNA in 10 × 10−3 m phosphate-buffered saline (1× PBS) selectively with a temporal resolution of <1 s in a flow of analyte with no incubation step. The detection time is <30 s and the relative standard deviation of the sensing reproducibility is <15% under the target concentration of 100 × 10−9 m.
Top-30
Citations by journals
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Chemosensors
1 publication, 20%
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Sensors
1 publication, 20%
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Advanced Materials
1 publication, 20%
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Chemical Reviews
1 publication, 20%
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Russian Chemical Reviews
1 publication, 20%
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Citations by publishers
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2
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 40%
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Wiley
1 publication, 20%
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American Chemical Society (ACS)
1 publication, 20%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 20%
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- We do not take into account publications without a DOI.
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Doumbia A. et al. Robust Microfluidic Integrated Electrolyte‐Gated Organic Field‐Effect Transistor Sensors for Rapid, In Situ and Label‐Free Monitoring of DNA Hybridization // Advanced Electronic Materials. 2022. Vol. 8. No. 9. p. 2200142.
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Doumbia A., Webb M., Behrendt J. M., Wilson R. J., Turner M. Robust Microfluidic Integrated Electrolyte‐Gated Organic Field‐Effect Transistor Sensors for Rapid, In Situ and Label‐Free Monitoring of DNA Hybridization // Advanced Electronic Materials. 2022. Vol. 8. No. 9. p. 2200142.
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TY - JOUR
DO - 10.1002/aelm.202200142
UR - https://doi.org/10.1002/aelm.202200142
TI - Robust Microfluidic Integrated Electrolyte‐Gated Organic Field‐Effect Transistor Sensors for Rapid, In Situ and Label‐Free Monitoring of DNA Hybridization
T2 - Advanced Electronic Materials
AU - Wilson, Richard J.
AU - Doumbia, Amadou
AU - Webb, Michelle
AU - Behrendt, Jonathan M
AU - Turner, Michael
PY - 2022
DA - 2022/05/31 00:00:00
PB - Wiley
SP - 2200142
IS - 9
VL - 8
SN - 2199-160X
SN - 2199-160X
ER -
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@article{2022_Doumbia,
author = {Richard J. Wilson and Amadou Doumbia and Michelle Webb and Jonathan M Behrendt and Michael Turner},
title = {Robust Microfluidic Integrated Electrolyte‐Gated Organic Field‐Effect Transistor Sensors for Rapid, In Situ and Label‐Free Monitoring of DNA Hybridization},
journal = {Advanced Electronic Materials},
year = {2022},
volume = {8},
publisher = {Wiley},
month = {may},
url = {https://doi.org/10.1002/aelm.202200142},
number = {9},
pages = {2200142},
doi = {10.1002/aelm.202200142}
}
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Doumbia, Amadou, et al. “Robust Microfluidic Integrated Electrolyte‐Gated Organic Field‐Effect Transistor Sensors for Rapid, In Situ and Label‐Free Monitoring of DNA Hybridization.” Advanced Electronic Materials, vol. 8, no. 9, May. 2022, p. 2200142. https://doi.org/10.1002/aelm.202200142.