Two-stage Regioselective Access to Non-symmetric 3,5-Diarylisoxazoles: Synthesis of Combretastatin A-4 analogues
Publication type: Journal Article
Publication date: 2021-11-10
scimago Q2
wos Q2
SJR: 0.542
CiteScore: 5.0
Impact factor: 2.7
ISSN: 21935807, 21935815
Organic Chemistry
Abstract
A new two‐stage regioselective access to non‐symmetric 3,5‐diarylisoxazoles starting from readily available 2‐aryl‐1,1‐dibromocyclopropanes is developed. The strategy based on the nitrosation/Suzuki arylation sequence ensures good yields of the products and a wide scope of substituents in both aryl rings. Using this strategy, a panel of combretastatin A‐4 (CA‐4) analogues presented by 3,5‐diarylisoxazole structural motif was synthesized and evaluated for their biological activity
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Karetnikov G. L. et al. Two-stage Regioselective Access to Non-symmetric 3,5-Diarylisoxazoles: Synthesis of Combretastatin A-4 analogues // Asian Journal of Organic Chemistry. 2021. Vol. 10. No. 12. pp. 3343-3348.
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Karetnikov G. L., Skvortsov D., Lopatukhina E. V., Nikolaeva S. N., Bondarenko O. B. Two-stage Regioselective Access to Non-symmetric 3,5-Diarylisoxazoles: Synthesis of Combretastatin A-4 analogues // Asian Journal of Organic Chemistry. 2021. Vol. 10. No. 12. pp. 3343-3348.
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TY - JOUR
DO - 10.1002/ajoc.202100551
UR - https://doi.org/10.1002/ajoc.202100551
TI - Two-stage Regioselective Access to Non-symmetric 3,5-Diarylisoxazoles: Synthesis of Combretastatin A-4 analogues
T2 - Asian Journal of Organic Chemistry
AU - Karetnikov, Georgy L
AU - Skvortsov, Dmitry
AU - Lopatukhina, Elena V.
AU - Nikolaeva, Svetlana N
AU - Bondarenko, Oksana B
PY - 2021
DA - 2021/11/10
PB - Wiley
SP - 3343-3348
IS - 12
VL - 10
SN - 2193-5807
SN - 2193-5815
ER -
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@article{2021_Karetnikov,
author = {Georgy L Karetnikov and Dmitry Skvortsov and Elena V. Lopatukhina and Svetlana N Nikolaeva and Oksana B Bondarenko},
title = {Two-stage Regioselective Access to Non-symmetric 3,5-Diarylisoxazoles: Synthesis of Combretastatin A-4 analogues},
journal = {Asian Journal of Organic Chemistry},
year = {2021},
volume = {10},
publisher = {Wiley},
month = {nov},
url = {https://doi.org/10.1002/ajoc.202100551},
number = {12},
pages = {3343--3348},
doi = {10.1002/ajoc.202100551}
}
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MLA
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Karetnikov, Georgy L., et al. “Two-stage Regioselective Access to Non-symmetric 3,5-Diarylisoxazoles: Synthesis of Combretastatin A-4 analogues.” Asian Journal of Organic Chemistry, vol. 10, no. 12, Nov. 2021, pp. 3343-3348. https://doi.org/10.1002/ajoc.202100551.