Targeting Histone Lysine Demethylases by Truncating the Histone 3 Tail to Obtain Selective Substrate-Based Inhibitors
Тип публикации: Journal Article
Дата публикации: 2011-08-25
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 5.495
CiteScore: 27.6
Impact factor: 16.9
ISSN: 14337851, 15213773
PubMed ID:
21919140
General Chemistry
Catalysis
Краткое описание
How low can you go? The natural substrate for the epigenetic regulators PHF8, JmjD2A, and JmjD2C (lysine demethylases), a peptide consisting of 39 amino acid residues, can be truncated to 14, 8, and 4 amino acids, respectively, while maintaining catalytic activity (see picture). Inhibitors were prepared by attaching small molecules to the truncated substrates. Selective inhibition of JmjD2C over JmjD2A and PHF8 was possible.
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Метрики
39
Всего цитирований:
39
Цитирований c 2025:
2
(5.12%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Lohse B. et al. Targeting Histone Lysine Demethylases by Truncating the Histone 3 Tail to Obtain Selective Substrate-Based Inhibitors // Angewandte Chemie - International Edition. 2011. Vol. 50. No. 39. pp. 9100-9103.
ГОСТ со всеми авторами (до 50)
Скопировать
Lohse B., Nielsen A. L., Kristensen J. B. L., Helgstrand C., Cloos P. A. C., Olsen L., Gajhede M., Clausen R. P., Kristensen J. L. Targeting Histone Lysine Demethylases by Truncating the Histone 3 Tail to Obtain Selective Substrate-Based Inhibitors // Angewandte Chemie - International Edition. 2011. Vol. 50. No. 39. pp. 9100-9103.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1002/anie.201101849
UR - https://doi.org/10.1002/anie.201101849
TI - Targeting Histone Lysine Demethylases by Truncating the Histone 3 Tail to Obtain Selective Substrate-Based Inhibitors
T2 - Angewandte Chemie - International Edition
AU - Lohse, Brian
AU - Nielsen, Anders L.
AU - Kristensen, Jan B L
AU - Helgstrand, C.
AU - Cloos, Paul A. C.
AU - Olsen, L.
AU - Gajhede, M.
AU - Clausen, Rasmus P.
AU - Kristensen, Jesper L.
PY - 2011
DA - 2011/08/25
PB - Wiley
SP - 9100-9103
IS - 39
VL - 50
PMID - 21919140
SN - 1433-7851
SN - 1521-3773
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2011_Lohse,
author = {Brian Lohse and Anders L. Nielsen and Jan B L Kristensen and C. Helgstrand and Paul A. C. Cloos and L. Olsen and M. Gajhede and Rasmus P. Clausen and Jesper L. Kristensen},
title = {Targeting Histone Lysine Demethylases by Truncating the Histone 3 Tail to Obtain Selective Substrate-Based Inhibitors},
journal = {Angewandte Chemie - International Edition},
year = {2011},
volume = {50},
publisher = {Wiley},
month = {aug},
url = {https://doi.org/10.1002/anie.201101849},
number = {39},
pages = {9100--9103},
doi = {10.1002/anie.201101849}
}
Цитировать
MLA
Скопировать
Lohse, Brian, et al. “Targeting Histone Lysine Demethylases by Truncating the Histone 3 Tail to Obtain Selective Substrate-Based Inhibitors.” Angewandte Chemie - International Edition, vol. 50, no. 39, Aug. 2011, pp. 9100-9103. https://doi.org/10.1002/anie.201101849.
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