An Organometallic Inhibitor for the Human Repair Enzyme 7,8‐Dihydro‐8‐oxoguanosine Triphosphatase
Manuel Streib
1
,
Katja Kräling
1
,
Kristin Richter
1
,
Xiulan Xie
1
,
Holger Steuber
2, 3
,
E. Meggers
4, 5
2
Current address: Bayer Pharma AG, Lead Discovery Berlin – Structural Biology, Müllerstrasse 178, 13353 Berlin (Germany)
|
Publication type: Journal Article
Publication date: 2013-11-20
scimago Q1
wos Q1
SJR: 5.550
CiteScore: 27.6
Impact factor: 16.9
ISSN: 14337851, 15213773
PubMed ID:
24258965
General Chemistry
Catalysis
Abstract
The probe‐based discovery of the first small‐molecule inhibitor of the repair enzyme 8‐oxo‐dGTPase (MTH1) is presented, which is an unconventional cyclometalated ruthenium half‐sandwich complex. The organometallic inhibitor with low‐nanomolar activity displays astonishing specificity, as verified in tests with an extended panel of protein kinases and other ATP binding proteins. The binding of the organometallic inhibitor to MTH1 is investigated by protein crystallography.
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Metrics
61
Total citations:
61
Citations from 2025:
2
(3.28%)
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GOST
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Streib M. et al. An Organometallic Inhibitor for the Human Repair Enzyme 7,8‐Dihydro‐8‐oxoguanosine Triphosphatase // Angewandte Chemie - International Edition. 2013. Vol. 53. No. 1. pp. 305-309.
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Streib M., Kräling K., Richter K., Xie X., Steuber H., Meggers E. An Organometallic Inhibitor for the Human Repair Enzyme 7,8‐Dihydro‐8‐oxoguanosine Triphosphatase // Angewandte Chemie - International Edition. 2013. Vol. 53. No. 1. pp. 305-309.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/anie.201307849
UR - https://onlinelibrary.wiley.com/doi/10.1002/anie.201307849
TI - An Organometallic Inhibitor for the Human Repair Enzyme 7,8‐Dihydro‐8‐oxoguanosine Triphosphatase
T2 - Angewandte Chemie - International Edition
AU - Streib, Manuel
AU - Kräling, Katja
AU - Richter, Kristin
AU - Xie, Xiulan
AU - Steuber, Holger
AU - Meggers, E.
PY - 2013
DA - 2013/11/20
PB - Wiley
SP - 305-309
IS - 1
VL - 53
PMID - 24258965
SN - 1433-7851
SN - 1521-3773
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2013_Streib,
author = {Manuel Streib and Katja Kräling and Kristin Richter and Xiulan Xie and Holger Steuber and E. Meggers},
title = {An Organometallic Inhibitor for the Human Repair Enzyme 7,8‐Dihydro‐8‐oxoguanosine Triphosphatase},
journal = {Angewandte Chemie - International Edition},
year = {2013},
volume = {53},
publisher = {Wiley},
month = {nov},
url = {https://onlinelibrary.wiley.com/doi/10.1002/anie.201307849},
number = {1},
pages = {305--309},
doi = {10.1002/anie.201307849}
}
Cite this
MLA
Copy
Streib, Manuel, et al. “An Organometallic Inhibitor for the Human Repair Enzyme 7,8‐Dihydro‐8‐oxoguanosine Triphosphatase.” Angewandte Chemie - International Edition, vol. 53, no. 1, Nov. 2013, pp. 305-309. https://onlinelibrary.wiley.com/doi/10.1002/anie.201307849.