Angewandte Chemie - International Edition, volume 54, issue 6, pages 1901-1905
Toward the design of a catalytic metallodrug: selective cleavage of G-quadruplex telomeric DNA by an anticancer copper-acridine-ATCUN complex.
Publication type: Journal Article
Publication date: 2014-12-11
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 16.6
ISSN: 14337851, 15213773
PubMed ID:
25504651
General Chemistry
Catalysis
Abstract
Telomeric DNA represents a novel target for the development of anticancer drugs. By application of a catalytic metallodrug strategy, a copper-acridine-ATCUN complex (CuGGHK-Acr) has been designed that targets G-quadruplex telomeric DNA. Both fluorescence solution assays and gel sequencing demonstrate the CuGGHK-Acr catalyst to selectively bind and cleave the G-quadruplex telomere sequence. The cleavage pathway has been mapped by matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) experiments. CuGGHK-Acr promotes significant inhibition of cancer cell proliferation and shortening of telomere length. Both senescence and apoptosis are induced in the breast cancer cell line MCF7.
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Yu Z., Han M., Cowan J. A. Toward the design of a catalytic metallodrug: selective cleavage of G-quadruplex telomeric DNA by an anticancer copper-acridine-ATCUN complex. // Angewandte Chemie - International Edition. 2014. Vol. 54. No. 6. pp. 1901-1905.
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Yu Z., Han M., Cowan J. A. Toward the design of a catalytic metallodrug: selective cleavage of G-quadruplex telomeric DNA by an anticancer copper-acridine-ATCUN complex. // Angewandte Chemie - International Edition. 2014. Vol. 54. No. 6. pp. 1901-1905.
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TY - JOUR
DO - 10.1002/anie.201410434
UR - https://doi.org/10.1002/anie.201410434
TI - Toward the design of a catalytic metallodrug: selective cleavage of G-quadruplex telomeric DNA by an anticancer copper-acridine-ATCUN complex.
T2 - Angewandte Chemie - International Edition
AU - Yu, Zhen
AU - Han, Menglu
AU - Cowan, James A
PY - 2014
DA - 2014/12/11
PB - Wiley
SP - 1901-1905
IS - 6
VL - 54
PMID - 25504651
SN - 1433-7851
SN - 1521-3773
ER -
Cite this
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@article{2014_Yu,
author = {Zhen Yu and Menglu Han and James A Cowan},
title = {Toward the design of a catalytic metallodrug: selective cleavage of G-quadruplex telomeric DNA by an anticancer copper-acridine-ATCUN complex.},
journal = {Angewandte Chemie - International Edition},
year = {2014},
volume = {54},
publisher = {Wiley},
month = {dec},
url = {https://doi.org/10.1002/anie.201410434},
number = {6},
pages = {1901--1905},
doi = {10.1002/anie.201410434}
}
Cite this
MLA
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Yu., Zhen, et al. “Toward the design of a catalytic metallodrug: selective cleavage of G-quadruplex telomeric DNA by an anticancer copper-acridine-ATCUN complex..” Angewandte Chemie - International Edition, vol. 54, no. 6, Dec. 2014, pp. 1901-1905. https://doi.org/10.1002/anie.201410434.