Mechanochemical Solvent‐Free Catalytic C−H Methylation
Shengjun Ni
1
,
Matic Hribersek
1
,
Swarna K Baddigam
1
,
Fredric J L Ingner
1
,
Andreas Orthaber
2
,
Paul J Gates
3
,
Lukasz T. Pilarski
1
Publication type: Journal Article
Publication date: 2020-12-17
scimago Q1
wos Q1
SJR: 5.550
CiteScore: 27.6
Impact factor: 16.9
ISSN: 14337851, 15213773
PubMed ID:
33031646
General Chemistry
Catalysis
Abstract
The mechanochemical, solvent-free, highly regioselective, rhodium-catalyzed C-H methylation of (hetero)arenes is reported. The reaction shows excellent functional-group compatibility and is demonstrated to work for the late-stage C-H methylation of biologically active compounds. The method requires no external heating and benefits from considerably shorter reaction times than previous solution-based C-H methylation protocols. Additionally, the mechanochemical approach is shown to enable the efficient synthesis of organometallic complexes that are difficult to generate conventionally.
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Metrics
118
Total citations:
118
Citations from 2025:
28
(23.72%)
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MLA
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GOST
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Ni S. et al. Mechanochemical Solvent‐Free Catalytic C−H Methylation // Angewandte Chemie - International Edition. 2020. Vol. 60. No. 12. pp. 6660-6666.
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Ni S., Hribersek M., Baddigam S. K., Ingner F. J. L., Orthaber A., Gates P. J., T. Pilarski L. Mechanochemical Solvent‐Free Catalytic C−H Methylation // Angewandte Chemie - International Edition. 2020. Vol. 60. No. 12. pp. 6660-6666.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/anie.202010202
UR - https://doi.org/10.1002/anie.202010202
TI - Mechanochemical Solvent‐Free Catalytic C−H Methylation
T2 - Angewandte Chemie - International Edition
AU - Ni, Shengjun
AU - Hribersek, Matic
AU - Baddigam, Swarna K
AU - Ingner, Fredric J L
AU - Orthaber, Andreas
AU - Gates, Paul J
AU - T. Pilarski, Lukasz
PY - 2020
DA - 2020/12/17
PB - Wiley
SP - 6660-6666
IS - 12
VL - 60
PMID - 33031646
SN - 1433-7851
SN - 1521-3773
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Ni,
author = {Shengjun Ni and Matic Hribersek and Swarna K Baddigam and Fredric J L Ingner and Andreas Orthaber and Paul J Gates and Lukasz T. Pilarski},
title = {Mechanochemical Solvent‐Free Catalytic C−H Methylation},
journal = {Angewandte Chemie - International Edition},
year = {2020},
volume = {60},
publisher = {Wiley},
month = {dec},
url = {https://doi.org/10.1002/anie.202010202},
number = {12},
pages = {6660--6666},
doi = {10.1002/anie.202010202}
}
Cite this
MLA
Copy
Ni, Shengjun, et al. “Mechanochemical Solvent‐Free Catalytic C−H Methylation.” Angewandte Chemie - International Edition, vol. 60, no. 12, Dec. 2020, pp. 6660-6666. https://doi.org/10.1002/anie.202010202.