15 N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields
Oleg G Salnikov
1, 2, 3
,
Belakovskiy D.I
2, 3
,
Alexandra Svyatova
2, 3
,
Ivan A Trofimov
2, 3
,
Mohammad S H Kabir
4
,
J. Gelovani
4, 5
,
Kirill V Kovtunov
2, 3
,
I. V. Koptyug
2, 3
,
Eduard Chekmenev
4, 6
3
5
6
Russian Academy of Sciences (RAS) 14 Leninskiy Prospekt 119991 Moscow Russia
|
Publication type: Journal Article
Publication date: 2020-12-01
scimago Q1
wos Q1
SJR: 5.550
CiteScore: 27.6
Impact factor: 16.9
ISSN: 14337851, 15213773
PubMed ID:
33063407
General Chemistry
Catalysis
Abstract
Synthesis of 15N3-enriched antibiotic and hypoxic radiosensitizer nimorazole is reported. Spin-relayed signal amplification by reversible exchange in microtesla magnetic field yielded up to 3.2 % 15N nuclear spin polarization with relaxation time constant of 5.9±0.2 min at 1.4 T. The isomer of nimorazole formed in the synthesis was also hyperpolarized indicating that this approach can be extended to a wide range of nitroimidazole-based drugs.
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Total citations:
43
Citations from 2025:
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(9.3%)
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GOST
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Salnikov O. G. et al. 15 N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields // Angewandte Chemie - International Edition. 2020. Vol. 60. No. 5. pp. 2406-2413.
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Salnikov O. G., D.I B., Svyatova A., Trofimov I. A., Kabir M. S. H., Gelovani J., Kovtunov K. V., Koptyug I. V., Chekmenev E. 15 N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields // Angewandte Chemie - International Edition. 2020. Vol. 60. No. 5. pp. 2406-2413.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/anie.202011698
UR - https://doi.org/10.1002/anie.202011698
TI - 15 N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields
T2 - Angewandte Chemie - International Edition
AU - Salnikov, Oleg G
AU - D.I, Belakovskiy
AU - Svyatova, Alexandra
AU - Trofimov, Ivan A
AU - Kabir, Mohammad S H
AU - Gelovani, J.
AU - Kovtunov, Kirill V
AU - Koptyug, I. V.
AU - Chekmenev, Eduard
PY - 2020
DA - 2020/12/01
PB - Wiley
SP - 2406-2413
IS - 5
VL - 60
PMID - 33063407
SN - 1433-7851
SN - 1521-3773
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Salnikov,
author = {Oleg G Salnikov and Belakovskiy D.I and Alexandra Svyatova and Ivan A Trofimov and Mohammad S H Kabir and J. Gelovani and Kirill V Kovtunov and I. V. Koptyug and Eduard Chekmenev},
title = {15 N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields},
journal = {Angewandte Chemie - International Edition},
year = {2020},
volume = {60},
publisher = {Wiley},
month = {dec},
url = {https://doi.org/10.1002/anie.202011698},
number = {5},
pages = {2406--2413},
doi = {10.1002/anie.202011698}
}
Cite this
MLA
Copy
Salnikov, Oleg G., et al. “15 N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields.” Angewandte Chemie - International Edition, vol. 60, no. 5, Dec. 2020, pp. 2406-2413. https://doi.org/10.1002/anie.202011698.