Journal of Applied Polymer Science, volume 100, issue 6, pages 4689-4696
Effect of degree of substitution and molecular weight of carboxymethyl chitosan nanoparticles on doxorubicin delivery
Publication type: Journal Article
Publication date: 2006-03-29
Journal:
Journal of Applied Polymer Science
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 3
ISSN: 00218995, 10974628
Materials Chemistry
Surfaces, Coatings and Films
General Chemistry
Polymers and Plastics
Abstract
The aim of this study was to evaluate the potential of carboxymethyl chitosan (CM-chitosan) nanoparticles as carriers for the anticancer drug, doxorubicin (DOX). Different kinds of CM-chitosan with various molecular weight (MW) and degree of substitution (DS) were employed to prepare nanoparticles through ionical gelification with calcium ions. Factors affecting nanoparticles formation in relation to MW and DS of CM-chitosan were discussed. By the way of dynamic light scattering (DLS), TEM, and atomic force microscopy (AFM), nanoparticles were shown to be around 200–300 nm and in a narrow distribution. FTIR revealed strong electrostatic interactions between carboxyl groups of CM-chitosan and calcium ions. DOX delivery was affected by the molecular structure of CM-chitosan. Increasing MWs of CM-chitosan from 4.50 to 38.9 kDa, DOX entrapment efficiency was enhanced from 10 to 40% and higher DS slightly improved the load of DOX. In vitro release studies showed an initial burst followed by an extended slow release. The DOX release rate was hindered by CM-chitosan with high MW and DS. These preliminary studies showed the feasibility of CM-chitosan nanoparticles to entrap DOX and the potential to deliver it as controlled release nanoparticles. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 4689–4696, 2006
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Citations by publishers
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2 publications, 2.63%
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1 publication, 1.32%
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1 publication, 1.32%
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1 publication, 1.32%
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1 publication, 1.32%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Shi X. et al. Effect of degree of substitution and molecular weight of carboxymethyl chitosan nanoparticles on doxorubicin delivery // Journal of Applied Polymer Science. 2006. Vol. 100. No. 6. pp. 4689-4696.
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Shi X., Du Y., Yang J., Zhang B., Sun L. Effect of degree of substitution and molecular weight of carboxymethyl chitosan nanoparticles on doxorubicin delivery // Journal of Applied Polymer Science. 2006. Vol. 100. No. 6. pp. 4689-4696.
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TY - JOUR
DO - 10.1002/app.23040
UR - https://doi.org/10.1002/app.23040
TI - Effect of degree of substitution and molecular weight of carboxymethyl chitosan nanoparticles on doxorubicin delivery
T2 - Journal of Applied Polymer Science
AU - Shi, Xiaowen
AU - Du, Yumin
AU - Yang, Jianhong
AU - Zhang, Baozhong
AU - Sun, Liping
PY - 2006
DA - 2006/03/29 00:00:00
PB - Wiley
SP - 4689-4696
IS - 6
VL - 100
SN - 0021-8995
SN - 1097-4628
ER -
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@article{2006_Shi,
author = {Xiaowen Shi and Yumin Du and Jianhong Yang and Baozhong Zhang and Liping Sun},
title = {Effect of degree of substitution and molecular weight of carboxymethyl chitosan nanoparticles on doxorubicin delivery},
journal = {Journal of Applied Polymer Science},
year = {2006},
volume = {100},
publisher = {Wiley},
month = {mar},
url = {https://doi.org/10.1002/app.23040},
number = {6},
pages = {4689--4696},
doi = {10.1002/app.23040}
}
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Shi, Xiaowen, et al. “Effect of degree of substitution and molecular weight of carboxymethyl chitosan nanoparticles on doxorubicin delivery.” Journal of Applied Polymer Science, vol. 100, no. 6, Mar. 2006, pp. 4689-4696. https://doi.org/10.1002/app.23040.