Journal of Applied Polymer Science, volume 123, issue 3, pages 1684-1689
Preparation, evaluation, and in vitro release study of O-carboxymethyl chitosan nanoparticles loaded with gentamicin and salicylic acid
1
Faculty of Pharmacy, College of Chemistry and Chemical Engineering, University of Chongqing, Chongqing 400030, China
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Publication type: Journal Article
Publication date: 2011-08-19
Journal:
Journal of Applied Polymer Science
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 3
ISSN: 00218995, 10974628
Materials Chemistry
Surfaces, Coatings and Films
General Chemistry
Polymers and Plastics
Abstract
To inhibit the ototoxicity of gentamicin (GM) and overcome the drawback related to chitosan (CS) nanoparticles preparation in acid solution, O-carboxymethyl chitosan (O-CMC) nanoparticles loaded with GM and salicylic acid (SA) were prepared by ionic cross-linking method using calcium chloride as crosslinking agent. The Fourier transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD) were used to analyze the reaction of O-CMC and crosslinking agent. The parameters of preparation of the compound nanoparticles including the concentration of O-CMC, the mass ratio of O-CMC to calcium chloride, and the feed ratio of SA to GM were investigated. The results showed that the obtained nanoparticles had a high zeta potential and drug-loading capacity. The nanoparticles were characterized by a spherical morphology, with average size ranging from 148 to 345 nm and a narrow particle size distribution. In vitro release studies in phosphate buffer saline (pH 7.4) evidenced a burst release in the first 1 h, followed by a sustained release in the residual time. The release amount of SA and GM were approximately equal in 24 h, which indicated that the SA- and GM-loaded O-CMC nanoparticles are a promising carrier system for inhibiting the ototoxicity of GM. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
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- We do not take into account publications without a DOI.
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Ji J. et al. Preparation, evaluation, and in vitro release study of O-carboxymethyl chitosan nanoparticles loaded with gentamicin and salicylic acid // Journal of Applied Polymer Science. 2011. Vol. 123. No. 3. pp. 1684-1689.
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Ji J., Hao S., Dong J., Wu D., Yang B., Xu Y. Preparation, evaluation, and in vitro release study of O-carboxymethyl chitosan nanoparticles loaded with gentamicin and salicylic acid // Journal of Applied Polymer Science. 2011. Vol. 123. No. 3. pp. 1684-1689.
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TY - JOUR
DO - 10.1002/app.34631
UR - https://doi.org/10.1002/app.34631
TI - Preparation, evaluation, and in vitro release study of O-carboxymethyl chitosan nanoparticles loaded with gentamicin and salicylic acid
T2 - Journal of Applied Polymer Science
AU - Ji, Jingou
AU - Hao, Shilei
AU - Dong, Jin
AU - Wu, Danjun
AU - Yang, Bin
AU - Xu, Yi
PY - 2011
DA - 2011/08/19 00:00:00
PB - Wiley
SP - 1684-1689
IS - 3
VL - 123
SN - 0021-8995
SN - 1097-4628
ER -
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@article{2011_Ji,
author = {Jingou Ji and Shilei Hao and Jin Dong and Danjun Wu and Bin Yang and Yi Xu},
title = {Preparation, evaluation, and in vitro release study of O-carboxymethyl chitosan nanoparticles loaded with gentamicin and salicylic acid},
journal = {Journal of Applied Polymer Science},
year = {2011},
volume = {123},
publisher = {Wiley},
month = {aug},
url = {https://doi.org/10.1002/app.34631},
number = {3},
pages = {1684--1689},
doi = {10.1002/app.34631}
}
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Ji, Jingou, et al. “Preparation, evaluation, and in vitro release study of O-carboxymethyl chitosan nanoparticles loaded with gentamicin and salicylic acid.” Journal of Applied Polymer Science, vol. 123, no. 3, Aug. 2011, pp. 1684-1689. https://doi.org/10.1002/app.34631.