Synthesis and Pharmacological Evaluation of Some Novel Thebaine Derivatives:N-(Tetrazol-1H-5-yl)-6,14-endoethenotetrahydrothebaine Incorporating the 1,3,4-Oxadiazole or the 1,3,4-Thiadiazole Moiety
Тип публикации: Journal Article
Дата публикации: 2013-05-03
SCImago Q2
WOS Q2
БС2
SJR: 0.527
CiteScore: 6.5
Impact factor: 3.5
ISSN: 03656233, 15214184
PubMed ID:
23649373
Drug Discovery
Pharmaceutical Science
Краткое описание
In this study, we synthesized some novel N-(tetrazol-1H-5-yl)-6,14-endoethenotetrahydrothebaine 7α-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives as potential analgesic agents. The structures of the compounds were established on the basis of their IR, ¹H NMR, ¹³C NMR, 2D NMR, and high-resolution mass spectral data. The analgesic activity was evaluated by a rat-hot plate test model and a rat tail-flick model. Compound 12 showed analgesic activity higher than that of morphine. In addition to a histopathological and biochemical evaluation, the LD₅₀ dose for the most active compound 12 was determined.
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Yavuz S. et al. Synthesis and Pharmacological Evaluation of Some Novel Thebaine Derivatives:N-(Tetrazol-1H-5-yl)-6,14-endoethenotetrahydrothebaine Incorporating the 1,3,4-Oxadiazole or the 1,3,4-Thiadiazole Moiety // Archiv der Pharmazie. 2013. Vol. 346. No. 6. pp. 455-462.
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Yavuz S., Unal Y., Pamir O., Yilmazer D., Kurtipek O., Kavutcu M., Arslan M., Ark M., Yıldırır Y. Synthesis and Pharmacological Evaluation of Some Novel Thebaine Derivatives:N-(Tetrazol-1H-5-yl)-6,14-endoethenotetrahydrothebaine Incorporating the 1,3,4-Oxadiazole or the 1,3,4-Thiadiazole Moiety // Archiv der Pharmazie. 2013. Vol. 346. No. 6. pp. 455-462.
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TY - JOUR
DO - 10.1002/ardp.201200451
UR - https://doi.org/10.1002/ardp.201200451
TI - Synthesis and Pharmacological Evaluation of Some Novel Thebaine Derivatives:N-(Tetrazol-1H-5-yl)-6,14-endoethenotetrahydrothebaine Incorporating the 1,3,4-Oxadiazole or the 1,3,4-Thiadiazole Moiety
T2 - Archiv der Pharmazie
AU - Yavuz, Serkan
AU - Unal, Yusuf
AU - Pamir, Ozgur
AU - Yilmazer, Demet
AU - Kurtipek, O.
AU - Kavutcu, M.
AU - Arslan, Mustafa
AU - Ark, Mustafa
AU - Yıldırır, Yılmaz
PY - 2013
DA - 2013/05/03
PB - Wiley
SP - 455-462
IS - 6
VL - 346
PMID - 23649373
SN - 0365-6233
SN - 1521-4184
ER -
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@article{2013_Yavuz,
author = {Serkan Yavuz and Yusuf Unal and Ozgur Pamir and Demet Yilmazer and O. Kurtipek and M. Kavutcu and Mustafa Arslan and Mustafa Ark and Yılmaz Yıldırır},
title = {Synthesis and Pharmacological Evaluation of Some Novel Thebaine Derivatives:N-(Tetrazol-1H-5-yl)-6,14-endoethenotetrahydrothebaine Incorporating the 1,3,4-Oxadiazole or the 1,3,4-Thiadiazole Moiety},
journal = {Archiv der Pharmazie},
year = {2013},
volume = {346},
publisher = {Wiley},
month = {may},
url = {https://doi.org/10.1002/ardp.201200451},
number = {6},
pages = {455--462},
doi = {10.1002/ardp.201200451}
}
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MLA
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Yavuz, Serkan, et al. “Synthesis and Pharmacological Evaluation of Some Novel Thebaine Derivatives:N-(Tetrazol-1H-5-yl)-6,14-endoethenotetrahydrothebaine Incorporating the 1,3,4-Oxadiazole or the 1,3,4-Thiadiazole Moiety.” Archiv der Pharmazie, vol. 346, no. 6, May. 2013, pp. 455-462. https://doi.org/10.1002/ardp.201200451.
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