Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1-c ][1,2,4]-triazines and Pyrazolo[5,1-c ][1,2,4]triazines as Potential Antidiabetic Agents
Тип публикации: Journal Article
Дата публикации: 2017-04-10
scimago Q2
wos Q2
БС2
SJR: 0.571
CiteScore: 7.0
Impact factor: 3.6
ISSN: 03656233, 15214184
PubMed ID:
28393419
Drug Discovery
Pharmaceutical Science
Краткое описание
Inhibition of the dipeptidyl peptidase-4 (DPP4) enzyme activity and prevention of advanced glycation end (AGE) products formation represents a reliable approach to achieve control over hyperglycemia and the associated pathogenesis of diabetic vascular complications. In the frames of this research study, several triazolo- and pyrazolotriazines were synthesized and evaluated as inhibitors of AGE products formation, DPP4, glycogen phosphorylase and α-glucosidase activities, as well as AGE cross-link breakers. From the two considered classes of heterocyclic compounds, the pyrazolotriazines showed the highest potency as antiglycating agents and DPP4 inhibitors. Structure-activity relationships (SAR) for these compounds, which can be considered as potential drugs for the treatment of type 2 diabetes, were evaluated.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Топ-30
Журналы
|
1
2
3
4
|
|
|
Russian Chemical Bulletin
4 публикации, 14.29%
|
|
|
Russian Journal of Organic Chemistry
2 публикации, 7.14%
|
|
|
Archiv der Pharmazie
2 публикации, 7.14%
|
|
|
European Journal of Medicinal Chemistry
2 публикации, 7.14%
|
|
|
Chemistry of Heterocyclic Compounds
2 публикации, 7.14%
|
|
|
Mendeleev Communications
2 публикации, 7.14%
|
|
|
Russian Journal of Bioorganic Chemistry
2 публикации, 7.14%
|
|
|
Chimica Techno Acta
2 публикации, 7.14%
|
|
|
Pharmaceuticals
1 публикация, 3.57%
|
|
|
Russian Chemical Reviews
1 публикация, 3.57%
|
|
|
Bioorganic Chemistry
1 публикация, 3.57%
|
|
|
Journal of Organic Chemistry
1 публикация, 3.57%
|
|
|
New Journal of Chemistry
1 публикация, 3.57%
|
|
|
Organic and Biomolecular Chemistry
1 публикация, 3.57%
|
|
|
Research Results in Pharmacology
1 публикация, 3.57%
|
|
|
Phosphorus, Sulfur and Silicon and the Related Elements
1 публикация, 3.57%
|
|
|
1
2
3
4
|
Издатели
|
1
2
3
4
5
6
|
|
|
Springer Nature
6 публикаций, 21.43%
|
|
|
Elsevier
5 публикаций, 17.86%
|
|
|
Pleiades Publishing
4 публикации, 14.29%
|
|
|
Wiley
2 публикации, 7.14%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
2 публикации, 7.14%
|
|
|
Royal Society of Chemistry (RSC)
2 публикации, 7.14%
|
|
|
Ural Federal University
2 публикации, 7.14%
|
|
|
MDPI
1 публикация, 3.57%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 публикация, 3.57%
|
|
|
American Chemical Society (ACS)
1 публикация, 3.57%
|
|
|
Belgorod National Research University
1 публикация, 3.57%
|
|
|
Taylor & Francis
1 публикация, 3.57%
|
|
|
1
2
3
4
5
6
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Метрики
28
Всего цитирований:
28
Цитирований c 2025:
3
(10.71%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Rusinov V. L. et al. Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1-c ][1,2,4]-triazines and Pyrazolo[5,1-c ][1,2,4]triazines as Potential Antidiabetic Agents // Archiv der Pharmazie. 2017. Vol. 350. No. 5. p. 1600361.
ГОСТ со всеми авторами (до 50)
Скопировать
Rusinov V. L., Sapozhnikova I. M., Bliznik A. M., Chupakhin O. N., Charushin V. N., Spasov A. A., Vassiliev P. M., Kuznetsova V. A., Rashchenko A. I., Babkov D. A. Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1-c ][1,2,4]-triazines and Pyrazolo[5,1-c ][1,2,4]triazines as Potential Antidiabetic Agents // Archiv der Pharmazie. 2017. Vol. 350. No. 5. p. 1600361.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1002/ardp.201600361
UR - https://doi.org/10.1002/ardp.201600361
TI - Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1-c ][1,2,4]-triazines and Pyrazolo[5,1-c ][1,2,4]triazines as Potential Antidiabetic Agents
T2 - Archiv der Pharmazie
AU - Rusinov, Vladimir L.
AU - Sapozhnikova, Irina M
AU - Bliznik, Anastasiya M
AU - Chupakhin, Oleg N.
AU - Charushin, Valery N.
AU - Spasov, Alexander A.
AU - Vassiliev, Pavel M
AU - Kuznetsova, Valentina A
AU - Rashchenko, Andrey I
AU - Babkov, Denis A
PY - 2017
DA - 2017/04/10
PB - Wiley
SP - 1600361
IS - 5
VL - 350
PMID - 28393419
SN - 0365-6233
SN - 1521-4184
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2017_Rusinov,
author = {Vladimir L. Rusinov and Irina M Sapozhnikova and Anastasiya M Bliznik and Oleg N. Chupakhin and Valery N. Charushin and Alexander A. Spasov and Pavel M Vassiliev and Valentina A Kuznetsova and Andrey I Rashchenko and Denis A Babkov},
title = {Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1-c ][1,2,4]-triazines and Pyrazolo[5,1-c ][1,2,4]triazines as Potential Antidiabetic Agents},
journal = {Archiv der Pharmazie},
year = {2017},
volume = {350},
publisher = {Wiley},
month = {apr},
url = {https://doi.org/10.1002/ardp.201600361},
number = {5},
pages = {1600361},
doi = {10.1002/ardp.201600361}
}
Цитировать
MLA
Скопировать
Rusinov, Vladimir L., et al. “Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1-c ][1,2,4]-triazines and Pyrazolo[5,1-c ][1,2,4]triazines as Potential Antidiabetic Agents.” Archiv der Pharmazie, vol. 350, no. 5, Apr. 2017, p. 1600361. https://doi.org/10.1002/ardp.201600361.