Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1-c ][1,2,4]-triazines and Pyrazolo[5,1-c ][1,2,4]triazines as Potential Antidiabetic Agents
Publication type: Journal Article
Publication date: 2017-04-10
scimago Q2
wos Q2
SJR: 0.571
CiteScore: 7.0
Impact factor: 3.6
ISSN: 03656233, 15214184
PubMed ID:
28393419
Drug Discovery
Pharmaceutical Science
Abstract
Inhibition of the dipeptidyl peptidase-4 (DPP4) enzyme activity and prevention of advanced glycation end (AGE) products formation represents a reliable approach to achieve control over hyperglycemia and the associated pathogenesis of diabetic vascular complications. In the frames of this research study, several triazolo- and pyrazolotriazines were synthesized and evaluated as inhibitors of AGE products formation, DPP4, glycogen phosphorylase and α-glucosidase activities, as well as AGE cross-link breakers. From the two considered classes of heterocyclic compounds, the pyrazolotriazines showed the highest potency as antiglycating agents and DPP4 inhibitors. Structure-activity relationships (SAR) for these compounds, which can be considered as potential drugs for the treatment of type 2 diabetes, were evaluated.
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28
Total citations:
28
Citations from 2024:
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(21%)
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GOST
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Rusinov V. L. et al. Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1-c ][1,2,4]-triazines and Pyrazolo[5,1-c ][1,2,4]triazines as Potential Antidiabetic Agents // Archiv der Pharmazie. 2017. Vol. 350. No. 5. p. 1600361.
GOST all authors (up to 50)
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Rusinov V. L., Sapozhnikova I. M., Bliznik A. M., Chupakhin O. N., Charushin V. N., Spasov A. A., Vassiliev P. M., Kuznetsova V. A., Rashchenko A. I., Babkov D. A. Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1-c ][1,2,4]-triazines and Pyrazolo[5,1-c ][1,2,4]triazines as Potential Antidiabetic Agents // Archiv der Pharmazie. 2017. Vol. 350. No. 5. p. 1600361.
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RIS
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TY - JOUR
DO - 10.1002/ardp.201600361
UR - https://doi.org/10.1002/ardp.201600361
TI - Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1-c ][1,2,4]-triazines and Pyrazolo[5,1-c ][1,2,4]triazines as Potential Antidiabetic Agents
T2 - Archiv der Pharmazie
AU - Rusinov, Vladimir L.
AU - Sapozhnikova, Irina M
AU - Bliznik, Anastasiya M
AU - Chupakhin, Oleg N.
AU - Charushin, Valery N.
AU - Spasov, Alexander A.
AU - Vassiliev, Pavel M
AU - Kuznetsova, Valentina A
AU - Rashchenko, Andrey I
AU - Babkov, Denis A
PY - 2017
DA - 2017/04/10
PB - Wiley
SP - 1600361
IS - 5
VL - 350
PMID - 28393419
SN - 0365-6233
SN - 1521-4184
ER -
Cite this
BibTex (up to 50 authors)
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@article{2017_Rusinov,
author = {Vladimir L. Rusinov and Irina M Sapozhnikova and Anastasiya M Bliznik and Oleg N. Chupakhin and Valery N. Charushin and Alexander A. Spasov and Pavel M Vassiliev and Valentina A Kuznetsova and Andrey I Rashchenko and Denis A Babkov},
title = {Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1-c ][1,2,4]-triazines and Pyrazolo[5,1-c ][1,2,4]triazines as Potential Antidiabetic Agents},
journal = {Archiv der Pharmazie},
year = {2017},
volume = {350},
publisher = {Wiley},
month = {apr},
url = {https://doi.org/10.1002/ardp.201600361},
number = {5},
pages = {1600361},
doi = {10.1002/ardp.201600361}
}
Cite this
MLA
Copy
Rusinov, Vladimir L., et al. “Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1-c ][1,2,4]-triazines and Pyrazolo[5,1-c ][1,2,4]triazines as Potential Antidiabetic Agents.” Archiv der Pharmazie, vol. 350, no. 5, Apr. 2017, p. 1600361. https://doi.org/10.1002/ardp.201600361.