(+)‐Camphor and (−)‐borneol derivatives as potential anti‐orthopoxvirus agents
Anastasiya S. Sokolova
1
,
Kseniya Kovaleva
1
,
Olga I. Yarovaya
1
,
Nikolay I. Bormotov
2
,
Larisa N. Shishkina
2
,
Olga A. Serova
2
,
Alexander A. Sergeev
2
,
Alexander P Agafonov
2
,
Rinat A Maksuytov
2
,
Тип публикации: Journal Article
Дата публикации: 2021-02-19
scimago Q2
wos Q2
БС2
SJR: 0.571
CiteScore: 7.0
Impact factor: 3.6
ISSN: 03656233, 15214184
PubMed ID:
33605479
Drug Discovery
Pharmaceutical Science
Краткое описание
Although the World Health Organisation had announced that smallpox was eradicated over 40 years ago, the disease and other related pathogenic poxviruses such as monkeypox remain potential bioterrorist weapons and could also re‐emerge as natural infections. We have previously reported (+)‐camphor and (−)‐borneol derivatives with an antiviral activity against the vaccinia virus. This virus is similar to the variola virus (VARV), the causative agent of smallpox, but can be studied at BSL‐2 facilities. In the present study, we evaluated the antiviral activity of the most potent compounds against VARV, cowpox virus, and ectromelia virus (ECTV). Among the compounds tested, 4‐bromo‐Nʹ‐((1R,4R)‐1,7,7‐trimethylbicyclo[2.2.1]heptan‐2‐ylidene)benzohydrazide 18 is the most effective compound against various orthopoxviruses, including VARV, with an EC50 value of 13.9 μM and a selectivity index of 206. Also, (+)‐camphor thiosemicarbazone 9 was found to be active against VARV and ECTV.
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Sokolova A. S. et al. (+)‐Camphor and (−)‐borneol derivatives as potential anti‐orthopoxvirus agents // Archiv der Pharmazie. 2021. Vol. 354. No. 6. p. 2100038.
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Sokolova A. S., Kovaleva K., Yarovaya O. I., Bormotov N. I., Shishkina L. N., Serova O. A., Sergeev A. A., Agafonov A. P., Maksuytov R. A., Salakhutdinov N. F. (+)‐Camphor and (−)‐borneol derivatives as potential anti‐orthopoxvirus agents // Archiv der Pharmazie. 2021. Vol. 354. No. 6. p. 2100038.
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TY - JOUR
DO - 10.1002/ardp.202100038
UR - https://doi.org/10.1002/ardp.202100038
TI - (+)‐Camphor and (−)‐borneol derivatives as potential anti‐orthopoxvirus agents
T2 - Archiv der Pharmazie
AU - Sokolova, Anastasiya S.
AU - Kovaleva, Kseniya
AU - Yarovaya, Olga I.
AU - Bormotov, Nikolay I.
AU - Shishkina, Larisa N.
AU - Serova, Olga A.
AU - Sergeev, Alexander A.
AU - Agafonov, Alexander P
AU - Maksuytov, Rinat A
AU - Salakhutdinov, Nariman F.
PY - 2021
DA - 2021/02/19
PB - Wiley
SP - 2100038
IS - 6
VL - 354
PMID - 33605479
SN - 0365-6233
SN - 1521-4184
ER -
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BibTex (до 50 авторов)
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@article{2021_Sokolova,
author = {Anastasiya S. Sokolova and Kseniya Kovaleva and Olga I. Yarovaya and Nikolay I. Bormotov and Larisa N. Shishkina and Olga A. Serova and Alexander A. Sergeev and Alexander P Agafonov and Rinat A Maksuytov and Nariman F. Salakhutdinov},
title = {(+)‐Camphor and (−)‐borneol derivatives as potential anti‐orthopoxvirus agents},
journal = {Archiv der Pharmazie},
year = {2021},
volume = {354},
publisher = {Wiley},
month = {feb},
url = {https://doi.org/10.1002/ardp.202100038},
number = {6},
pages = {2100038},
doi = {10.1002/ardp.202100038}
}
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MLA
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Sokolova, Anastasiya S., et al. “(+)‐Camphor and (−)‐borneol derivatives as potential anti‐orthopoxvirus agents.” Archiv der Pharmazie, vol. 354, no. 6, Feb. 2021, p. 2100038. https://doi.org/10.1002/ardp.202100038.
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