Chemistry - An Asian Journal, volume 10, issue 2, pages 383-389
Structural studies and anticancer activity of a novel class of β-peptides
Publication type: Journal Article
Publication date: 2014-11-18
Journal:
Chemistry - An Asian Journal
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 4.1
ISSN: 18614728, 1861471X
General Chemistry
Organic Chemistry
Biochemistry
Abstract
Functionalized oligomeric organic compounds with well-defined β-proline scaffold have been synthesized by a cycloadditive oligomerization approach in racemic and enantiopure forms. The structure of the novel β-peptides was investigated by NMR spectroscopic and X-ray methods determining the conformational shapes of the β-proline oligomers in solution and solid states. The main structural elements subject to conformational switches are β-peptide bonds between 5-arylpyrrolidine-2-carboxylic acid units existing in Z/E configurations. The whole library of short β-peptides and intermediate acrylamides has been tested on antiproliferative activity towards the hormone-refractory prostate cancer cell line PC-3 revealing several oligomeric compounds with low micromolar and submicromolar activities. Bromine-substituted dimeric and trimeric acrylamides induced caspase-dependent apoptosis of PC-3 cells through cell-cycle arrest and mitochondrial damage.
Citations by journals
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Organic Letters
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3 publications, 18.75%
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Acta Crystallographica Section E: Crystallographic Communications
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Acta Crystallographica Section E: Crystallographic Communications
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Journal of Organic Chemistry
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1 publication, 6.25%
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1 publication, 6.25%
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Oncotarget
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Oncotarget
1 publication, 6.25%
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Pharmaceutical Chemistry Journal
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1 publication, 6.25%
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European Journal of Medicinal Chemistry
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1 publication, 6.25%
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Bioorganic and Medicinal Chemistry Letters
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1 publication, 6.25%
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1 publication, 6.25%
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ChemistrySelect
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ChemistrySelect
1 publication, 6.25%
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RSC Advances
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RSC Advances
1 publication, 6.25%
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1 publication, 6.25%
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3
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Citations by publishers
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4
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American Chemical Society (ACS)
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4 publications, 25%
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Elsevier
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Elsevier
2 publications, 12.5%
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Wiley
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Wiley
2 publications, 12.5%
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International Union of Crystallography (IUCr)
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International Union of Crystallography (IUCr)
1 publication, 6.25%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 6.25%
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Impact Journals
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Impact Journals
1 publication, 6.25%
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Springer Nature
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Springer Nature
1 publication, 6.25%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
1 publication, 6.25%
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Thieme
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Thieme
1 publication, 6.25%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Kudryavtsev K. V. et al. Structural studies and anticancer activity of a novel class of β-peptides // Chemistry - An Asian Journal. 2014. Vol. 10. No. 2. pp. 383-389.
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Kudryavtsev K. V., Yu C., Ivantcova P. M., Polshakov V. I., Churakov A. V., Bräse S., Zefirov N. S., Guh J. Structural studies and anticancer activity of a novel class of β-peptides // Chemistry - An Asian Journal. 2014. Vol. 10. No. 2. pp. 383-389.
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TY - JOUR
DO - 10.1002/asia.201403171
UR - https://doi.org/10.1002%2Fasia.201403171
TI - Structural studies and anticancer activity of a novel class of β-peptides
T2 - Chemistry - An Asian Journal
AU - Kudryavtsev, Konstantin V.
AU - Yu, Chia-Chun
AU - Polshakov, Vladimir I
AU - Churakov, Andrei V.
AU - Bräse, Stefan
AU - Zefirov, Nikolay S.
AU - Guh, Jih-Hwa
AU - Ivantcova, Polina M.
PY - 2014
DA - 2014/11/18 00:00:00
PB - Wiley
SP - 383-389
IS - 2
VL - 10
SN - 1861-4728
SN - 1861-471X
ER -
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@article{2014_Kudryavtsev,
author = {Konstantin V. Kudryavtsev and Chia-Chun Yu and Vladimir I Polshakov and Andrei V. Churakov and Stefan Bräse and Nikolay S. Zefirov and Jih-Hwa Guh and Polina M. Ivantcova},
title = {Structural studies and anticancer activity of a novel class of β-peptides},
journal = {Chemistry - An Asian Journal},
year = {2014},
volume = {10},
publisher = {Wiley},
month = {nov},
url = {https://doi.org/10.1002%2Fasia.201403171},
number = {2},
pages = {383--389},
doi = {10.1002/asia.201403171}
}
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MLA
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Kudryavtsev, Konstantin V., et al. “Structural studies and anticancer activity of a novel class of β-peptides.” Chemistry - An Asian Journal, vol. 10, no. 2, Nov. 2014, pp. 383-389. https://doi.org/10.1002%2Fasia.201403171.
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