Synthesis of picramide using nitration and ammonolysis in continuous flow
Publication type: Journal Article
Publication date: 2022-12-09
scimago Q2
wos Q2
SJR: 0.751
CiteScore: 5.9
Impact factor: 3.3
ISSN: 18614728, 1861471X
PubMed ID:
36484628
General Chemistry
Organic Chemistry
Biochemistry
Abstract
This paper describes a safer, scalable and continuous process for synthesis of picramide. The process consists of two steps: step-1. nitration of p-nitroanisole (PNAN) to 2,4,6-trinitrianisole (TNAN); step-2. ammonolysis of TNAN to picramide. Both the steps were optimized in flow, with yield of 90% and 98% in step-1 and step-2 respectively. Picramide with HPLC purity greater than 99% was obtained. When compared with batch, in step-1, flow process provided significant advantage in selectivity and yield. The optimized flow process was scaled to 25 g/hr production rate in a laboratory flow reactor. The method can be considered fit for the safe production of picramide at commercial scale.
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6
Total citations:
6
Citations from 2025:
3
(50%)
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GOST
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Kumar Mittal A. et al. Synthesis of picramide using nitration and ammonolysis in continuous flow // Chemistry - An Asian Journal. 2022. Vol. 18. No. 2.
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Kumar Mittal A., Prakash G., Pathak P., Maiti D. Synthesis of picramide using nitration and ammonolysis in continuous flow // Chemistry - An Asian Journal. 2022. Vol. 18. No. 2.
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RIS
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TY - JOUR
DO - 10.1002/asia.202201028
UR - https://doi.org/10.1002/asia.202201028
TI - Synthesis of picramide using nitration and ammonolysis in continuous flow
T2 - Chemistry - An Asian Journal
AU - Kumar Mittal, Ankit
AU - Prakash, Gaurav
AU - Pathak, Pramod
AU - Maiti, Debabrata
PY - 2022
DA - 2022/12/09
PB - Wiley
IS - 2
VL - 18
PMID - 36484628
SN - 1861-4728
SN - 1861-471X
ER -
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BibTex (up to 50 authors)
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@article{2022_Kumar Mittal,
author = {Ankit Kumar Mittal and Gaurav Prakash and Pramod Pathak and Debabrata Maiti},
title = {Synthesis of picramide using nitration and ammonolysis in continuous flow},
journal = {Chemistry - An Asian Journal},
year = {2022},
volume = {18},
publisher = {Wiley},
month = {dec},
url = {https://doi.org/10.1002/asia.202201028},
number = {2},
doi = {10.1002/asia.202201028}
}