том 2 издание 4 страницы 557-567

Design, Synthesis, and Biological Evaluation of New Territrem B Analogues

Тип публикацииJournal Article
Дата публикации2005-04-18
scimago Q3
wos Q3
БС2
SJR0.425
CiteScore3.5
Impact factor2.5
ISSN16121872, 16121880
General Chemistry
Biochemistry
Molecular Biology
General Medicine
Molecular Medicine
Bioengineering
Краткое описание
Some 23 analogues of the potent acetylcholinesterase (AChE) inhibitor territrem B (1) were designed, synthesized, and tested for their biological activities. Some of the new synthetic derivatives exhibited IC50 values for AChE inhibition in the upper micromolar range. Molecular-modeling studies indicated that a planar conformation seems to be crucial for AChE inhibition. The two N-atoms of the piperazine moieties in 5o, 5p, and 5r might further enhance the inhibitory effects. The cytotoxicities of selected compounds against six human tumor cell lines were also determined.
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ГОСТ |
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Jiang X. et al. Design, Synthesis, and Biological Evaluation of New Territrem B Analogues // Chemistry and Biodiversity. 2005. Vol. 2. No. 4. pp. 557-567.
ГОСТ со всеми авторами (до 50) Скопировать
Jiang X., Ao L., Zhou C., Yang L., Zhang Q., Li H., Sun L., Wu X., Bai H., Zhou Y. Design, Synthesis, and Biological Evaluation of New Territrem B Analogues // Chemistry and Biodiversity. 2005. Vol. 2. No. 4. pp. 557-567.
RIS |
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TY - JOUR
DO - 10.1002/cbdv.200590036
UR - https://doi.org/10.1002/cbdv.200590036
TI - Design, Synthesis, and Biological Evaluation of New Territrem B Analogues
T2 - Chemistry and Biodiversity
AU - Jiang, Xiangrui
AU - Ao, Lei
AU - Zhou, Changxin
AU - Yang, Leixiang
AU - Zhang, Qijun
AU - Li, Haibo
AU - Sun, Lian-li
AU - Wu, Xiumei
AU - Bai, Hua
AU - Zhou, Yu-Tao
PY - 2005
DA - 2005/04/18
PB - Wiley
SP - 557-567
IS - 4
VL - 2
PMID - 17192004
SN - 1612-1872
SN - 1612-1880
ER -
BibTex |
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BibTex (до 50 авторов) Скопировать
@article{2005_Jiang,
author = {Xiangrui Jiang and Lei Ao and Changxin Zhou and Leixiang Yang and Qijun Zhang and Haibo Li and Lian-li Sun and Xiumei Wu and Hua Bai and Yu-Tao Zhou},
title = {Design, Synthesis, and Biological Evaluation of New Territrem B Analogues},
journal = {Chemistry and Biodiversity},
year = {2005},
volume = {2},
publisher = {Wiley},
month = {apr},
url = {https://doi.org/10.1002/cbdv.200590036},
number = {4},
pages = {557--567},
doi = {10.1002/cbdv.200590036}
}
MLA
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Jiang, Xiangrui, et al. “Design, Synthesis, and Biological Evaluation of New Territrem B Analogues.” Chemistry and Biodiversity, vol. 2, no. 4, Apr. 2005, pp. 557-567. https://doi.org/10.1002/cbdv.200590036.