Cytotoxic Activities of Amino Acid-Conjugate Derivatives of Abietane-Type Diterpenoids against Human Cancer Cell Lines
Тип публикации: Journal Article
Дата публикации: 2013-07-12
SCImago Q2
WOS Q3
БС2
SJR: 0.449
CiteScore: 3.7
Impact factor: 2.9
ISSN: 16121872, 16121880
PubMed ID:
23847070
General Chemistry
Biochemistry
Molecular Biology
General Medicine
Molecular Medicine
Bioengineering
Краткое описание
Nine amino acid conjugate derivatives, each 2-10 and 12-20, were prepared from abietic acid (1) and dehydroabietic acid (11), respectively, and they were evaluated for their cytotoxicities against four human cancer cell lines, i.e., leukemia (HL60), lung (A549), stomach (AZ521), and breast (SK-BR-3). All compounds showed cytotoxicities against HL60 with IC50 values in the range of 2.3-37.3 μM. In addition, most of the derivatives exhibited moderate cytotoxicities against the other cancer cell lines. Among the derivatives, methyl N-[18-oxoabieta-8,11,13-trien-18-yl]-L-tyrosinate (19) exhibited potent cytotoxic activities against four cancer cell lines with IC50 values of 2.3 (HL60), 7.1 (A549), 3.9 (AZ521), and 8.1 μM (SK-BR-3). Furthermore, all derivatives were shown to possess high selective cytotoxic activities for leukemia cells, since they exhibited only weak cytotoxicities against normal lymphocyte cell line RPMI1788.
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Ukiya M. et al. Cytotoxic Activities of Amino Acid-Conjugate Derivatives of Abietane-Type Diterpenoids against Human Cancer Cell Lines // Chemistry and Biodiversity. 2013. Vol. 10. No. 7. pp. 1260-1268.
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Ukiya M., KAWAGUCHI T., Ishii K., Ogihara E., Tachi Y., KURITA M., Ezaki Y., Fukatsu M., Kushi Y., Akihisa T. Cytotoxic Activities of Amino Acid-Conjugate Derivatives of Abietane-Type Diterpenoids against Human Cancer Cell Lines // Chemistry and Biodiversity. 2013. Vol. 10. No. 7. pp. 1260-1268.
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TY - JOUR
DO - 10.1002/cbdv.201300043
UR - https://doi.org/10.1002/cbdv.201300043
TI - Cytotoxic Activities of Amino Acid-Conjugate Derivatives of Abietane-Type Diterpenoids against Human Cancer Cell Lines
T2 - Chemistry and Biodiversity
AU - Ukiya, Motohiko
AU - KAWAGUCHI, Takuma
AU - Ishii, Kenta
AU - Ogihara, Eri
AU - Tachi, Yosuke
AU - KURITA, Masahiro
AU - Ezaki, Yoichiro
AU - Fukatsu, Makoto
AU - Kushi, Yasunori
AU - Akihisa, Toshihiro
PY - 2013
DA - 2013/07/12
PB - Wiley
SP - 1260-1268
IS - 7
VL - 10
PMID - 23847070
SN - 1612-1872
SN - 1612-1880
ER -
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@article{2013_Ukiya,
author = {Motohiko Ukiya and Takuma KAWAGUCHI and Kenta Ishii and Eri Ogihara and Yosuke Tachi and Masahiro KURITA and Yoichiro Ezaki and Makoto Fukatsu and Yasunori Kushi and Toshihiro Akihisa},
title = {Cytotoxic Activities of Amino Acid-Conjugate Derivatives of Abietane-Type Diterpenoids against Human Cancer Cell Lines},
journal = {Chemistry and Biodiversity},
year = {2013},
volume = {10},
publisher = {Wiley},
month = {jul},
url = {https://doi.org/10.1002/cbdv.201300043},
number = {7},
pages = {1260--1268},
doi = {10.1002/cbdv.201300043}
}
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MLA
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Ukiya, Motohiko, et al. “Cytotoxic Activities of Amino Acid-Conjugate Derivatives of Abietane-Type Diterpenoids against Human Cancer Cell Lines.” Chemistry and Biodiversity, vol. 10, no. 7, Jul. 2013, pp. 1260-1268. https://doi.org/10.1002/cbdv.201300043.
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