Chemistry and Biodiversity

, volume 15 , issue 9 , pages e1800153

Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor

Anastasiya S. Sokolova ¹

Olga I. Yarovaya ^{1, 2}

Nikolay I. Bormotov ³

Larisa N. Shishkina ³

Nariman F. Salakhutdinov ^{1, 2}

Hide authors affiliations Show authors affiliations: 3 affiliations

Department of Medicinal Chemistry; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry; Siberian Branch Russian Academy of Sciences; 9, Lavrent'ev ave Novosibirsk 630090 Russian Federation |

Laboratory of New Medicines; Novosibirsk State University; 2, Pirogova Street Novosibirsk 630090 Russian Federation |

Department of Prevention and Treatment of Especially Dangerous Infections; State Research Center of Virology and Biotechnology Vector; Koltsovo, Novosibirsk Region 630559 Russian Federation |

Publication type: Journal Article

Publication date: 2018-08-09

Wiley

Chemistry and Biodiversity

scimago Q3

wos Q3

SJR: 0.425

CiteScore: 3.5

Impact factor: 2.5

ISSN: 16121872, 16121880

DOI: 10.1002/cbdv.201800153

Copy DOI

PubMed ID: 29956885

General Chemistry

Biochemistry

Molecular Biology

General Medicine

Molecular Medicine

Bioengineering

Abstract

A series of the bornyl ester/amide derivatives with N‐containing heterocycles were designed and synthesized as vaccinia virus (VV) inhibitors. Bioassay results showed that among the designed compounds, derivatives 6, 13, 14, 34, 36 and 37 showed the best inhibitory activity against VV with the IC₅₀ values of 12.9, 17.9, 3.4, 2.5, 12.5 and 7.5 μm, respectively, and good cytotoxicity. The primary structure–activity relationship (SAR) study suggested that the combination of a saturated N‐heterocycle, such as morpholine or 4‐methylpiperidine, and a 1,7,7‐trimethylbicyclo[2.2.1]heptane scaffold was favorable for antiviral activity.

Found

20 citations

Yarovaya Olga

PhD in Chemistry

117 publications, 1 801 citations, 14 reviews

h-index: 23

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences

5 citations

Baev Dmitry

PhD in Biological/biomedical sciences

68 publications, 976 citations

h-index: 19

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences

2 citations

Volcho Konstantin

DSc in Chemistry, professor of the Russian Academy of Sciences

279 publications, 3 898 citations, 65 reviews

h-index: 31

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences

2 citations

Zubkov Fedor

🥼 🤝

DSc in Chemistry, professor

240 publications, 3 226 citations, 19 reviews

h-index: 31

Peoples' Friendship University of Russia

Research interests

Organic Chemistry

2 citations

Vernigora Andrey

🤝

27 publications, 127 citations

h-index: 7

Volgograd State Technical University

Research interests

Medicinal Chemistry

1 citation

Osipov Sergey

DSc in Chemistry

138 publications, 2 739 citations, 3 reviews

h-index: 29

A.N.Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences

1 citation

Karasik Andrey

DSc in Chemistry, professor, associate member of the Russian Academy of Sciences

224 publications, 2 599 citations

h-index: 26

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Coordination Chemistry

Luminescence

Phosphorus ligands

1 citation

Dotsenko Viktor

DSc in Chemistry, professor

244 publications, 2 741 citations, 2 reviews

h-index: 22

North Caucasus Federal University

Kuban State University

Research interests

Active methylene compounds

Biological activity

Heterocyclic compounds

Malononitrile

Selenoamides

Thioamides

1 citation

Zagidullin Almaz

🥼 🤝

PhD in Chemistry

81 publications, 884 citations

h-index: 17

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Asymmetric metal complex catalysis

Chemistry of organic and organoelement compounds; chemistry of polymers; production of materials

Coordination chemistry of phosphorus

Organoelement chemistry

Organophosphorus chemistry

Synthesis of chiral phosphorus-containing ligands

1 citation

Aksenov Aleksandr

🥼 🤝

DSc in Chemistry, professor

243 publications, 2 187 citations, 15 reviews

h-index: 24

North Caucasus Federal University

Research interests

Medicinal Chemistry

Organic Chemistry

1 citation

Antonova Alexandra

PhD in Chemistry

10 publications, 53 citations

h-index: 4

Peoples' Friendship University of Russia

A.N.Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences

Research interests

Coordination Chemistry

Organic Chemistry

1 citation

Sosnovskikh Vyacheslav

DSc in Chemistry, professor

355 publications, 4 721 citations

h-index: 30

Ural Federal University

1 citation

Mozhaitsev Evgenii

PhD in Chemistry

26 publications, 270 citations

h-index: 11

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences

1 citation

Ilkin Vladimir

PhD in Chemistry

16 publications, 187 citations

h-index: 7

Ural Federal University

Research interests

Catalysis

Heterocyclic compounds

Organic Chemistry

Synthetic Organic Chemistry

1 citation

Krylov Igor

PhD in Chemistry

78 publications, 1 885 citations, 18 reviews

h-index: 25

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Research interests

Green chemistry

Organic Chemistry

Organic electrochemistry

Organic synthesis

Photochemistry

Plant protection

1 citation

Shtro Anna

🥼 🤝

PhD in Biological/biomedical sciences

73 publications, 1 152 citations, 1 review

h-index: 20

Smorodintsev Research Institute of Influenza

Research interests

Pharmacology

Virology

1 citation

Galochkina Aнастасия

🤝

PhD in Biological/biomedical sciences

34 publications, 401 citations

h-index: 13

Smorodintsev Research Institute of Influenza

1 citation

Tikhomirov Alexander

🥼 🤝

DSc in Chemistry, associate professor

59 publications, 920 citations

h-index: 17

Mendeleev University of Chemical Technology of Russia

Gause Institute of New Antibiotics

Research interests

Medicinal Chemistry

1 citation

Ivanov Andrey

54 publications, 534 citations

h-index: 12

A.E. Favorsky Irkutsk Institute of Chemistry of the Siberian Branch of the Russian Academy of Sciences

Top-30

Journals

	1 2 3
Russian Chemical Bulletin	Russian Chemical Bulletin, 3, 8.82% Russian Chemical Bulletin 3 publications, 8.82%
Russian Chemical Reviews	Russian Chemical Reviews, 2, 5.88% Russian Chemical Reviews 2 publications, 5.88%
MedChemComm	MedChemComm, 2, 5.88% MedChemComm 2 publications, 5.88%
Molecules	Molecules, 2, 5.88% Molecules 2 publications, 5.88%
Bioorganic and Medicinal Chemistry Letters	Bioorganic and Medicinal Chemistry Letters, 2, 5.88% Bioorganic and Medicinal Chemistry Letters 2 publications, 5.88%
European Journal of Medicinal Chemistry	European Journal of Medicinal Chemistry, 2, 5.88% European Journal of Medicinal Chemistry 2 publications, 5.88%
Archiv der Pharmazie	Archiv der Pharmazie, 2, 5.88% Archiv der Pharmazie 2 publications, 5.88%
Topics in Current Chemistry	Topics in Current Chemistry, 1, 2.94% Topics in Current Chemistry 1 publication, 2.94%
RSC Medicinal Chemistry	RSC Medicinal Chemistry, 1, 2.94% RSC Medicinal Chemistry 1 publication, 2.94%
Viruses	Viruses, 1, 2.94% Viruses 1 publication, 2.94%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 2.94% International Journal of Molecular Sciences 1 publication, 2.94%
Chemistry of Heterocyclic Compounds	Chemistry of Heterocyclic Compounds, 1, 2.94% Chemistry of Heterocyclic Compounds 1 publication, 2.94%
Journal of Medicinal Chemistry	Journal of Medicinal Chemistry, 1, 2.94% Journal of Medicinal Chemistry 1 publication, 2.94%
Journal of Pharmaceutical and Biomedical Analysis	Journal of Pharmaceutical and Biomedical Analysis, 1, 2.94% Journal of Pharmaceutical and Biomedical Analysis 1 publication, 2.94%
Phytomedicine	Phytomedicine, 1, 2.94% Phytomedicine 1 publication, 2.94%
Basic and Clinical Pharmacology and Toxicology	Basic and Clinical Pharmacology and Toxicology, 1, 2.94% Basic and Clinical Pharmacology and Toxicology 1 publication, 2.94%
ChemMedChem	ChemMedChem, 1, 2.94% ChemMedChem 1 publication, 2.94%
Toxicology Research	Toxicology Research, 1, 2.94% Toxicology Research 1 publication, 2.94%
Medicinal Chemistry	Medicinal Chemistry, 1, 2.94% Medicinal Chemistry 1 publication, 2.94%
Journal of Molecular Structure	Journal of Molecular Structure, 1, 2.94% Journal of Molecular Structure 1 publication, 2.94%
Journal of Molecular Liquids	Journal of Molecular Liquids, 1, 2.94% Journal of Molecular Liquids 1 publication, 2.94%
PLoS ONE	PLoS ONE, 1, 2.94% PLoS ONE 1 publication, 2.94%
Russian Journal of General Chemistry	Russian Journal of General Chemistry, 1, 2.94% Russian Journal of General Chemistry 1 publication, 2.94%
European Journal of Pharmacology	European Journal of Pharmacology, 1, 2.94% European Journal of Pharmacology 1 publication, 2.94%
New Journal of Chemistry	New Journal of Chemistry, 1, 2.94% New Journal of Chemistry 1 publication, 2.94%
	1 2 3

Publishers

	2 4 6 8 10
Elsevier	Elsevier, 10, 29.41% Elsevier 10 publications, 29.41%
Springer Nature	Springer Nature, 5, 14.71% Springer Nature 5 publications, 14.71%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 4, 11.76% Royal Society of Chemistry (RSC) 4 publications, 11.76%
MDPI	MDPI, 4, 11.76% MDPI 4 publications, 11.76%
Wiley	Wiley, 4, 11.76% Wiley 4 publications, 11.76%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 2, 5.88% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 2 publications, 5.88%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 2.94% American Chemical Society (ACS) 1 publication, 2.94%
Oxford University Press	Oxford University Press, 1, 2.94% Oxford University Press 1 publication, 2.94%
Bentham Science Publishers Ltd.	Bentham Science Publishers Ltd., 1, 2.94% Bentham Science Publishers Ltd. 1 publication, 2.94%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 2.94% Public Library of Science (PLoS) 1 publication, 2.94%
Pleiades Publishing	Pleiades Publishing, 1, 2.94% Pleiades Publishing 1 publication, 2.94%
	2 4 6 8 10

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST |

Cite this

GOST Copy

Sokolova A. S. et al. Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor // Chemistry and Biodiversity. 2018. Vol. 15. No. 9. p. e1800153.

GOST all authors (up to 50) Copy

Sokolova A. S., Yarovaya O. I., Bormotov N. I., Shishkina L. N., Salakhutdinov N. F. Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor // Chemistry and Biodiversity. 2018. Vol. 15. No. 9. p. e1800153.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1002/cbdv.201800153

UR - https://doi.org/10.1002/cbdv.201800153

TI - Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor

T2 - Chemistry and Biodiversity

AU - Sokolova, Anastasiya S.

AU - Yarovaya, Olga I.

AU - Bormotov, Nikolay I.

AU - Shishkina, Larisa N.

AU - Salakhutdinov, Nariman F.

PY - 2018

DA - 2018/08/09

PB - Wiley

SP - e1800153

IS - 9

VL - 15

PMID - 29956885

SN - 1612-1872

SN - 1612-1880

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2018_Sokolova,

author = {Anastasiya S. Sokolova and Olga I. Yarovaya and Nikolay I. Bormotov and Larisa N. Shishkina and Nariman F. Salakhutdinov},

title = {Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor},

journal = {Chemistry and Biodiversity},

year = {2018},

volume = {15},

publisher = {Wiley},

month = {aug},

url = {https://doi.org/10.1002/cbdv.201800153},

number = {9},

pages = {e1800153},

doi = {10.1002/cbdv.201800153}

}

MLA

Cite this

MLA Copy

Sokolova, Anastasiya S., et al. “Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor.” Chemistry and Biodiversity, vol. 15, no. 9, Aug. 2018, p. e1800153. https://doi.org/10.1002/cbdv.201800153.

Publisher

Wiley

Journal

Chemistry and Biodiversity

scimago Q3

wos Q3

SJR

0.425

CiteScore

3.5

Impact factor

2.5

ISSN

16121872 (Print)

16121880 (Electronic)

Profiles