ChemBioChem, volume 23, issue 12
Tetraphenylethene Derivatives Modulate the RNA Hairpin‐G‐Quadruplex Conformational Equilibria in Proto‐oncogenes**
1
Regional Centre for Biotechnology NCR Biotech Science Cluster, 3rd Milestone Faridabad – Gurugram Expressway Faridabad Haryana 121001 India
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Publication type: Journal Article
Publication date: 2022-05-11
Journal:
ChemBioChem
Quartile SCImago
Q1
Quartile WOS
Q3
Impact factor: 3.2
ISSN: 14394227, 14397633
Organic Chemistry
Biochemistry
Molecular Biology
Molecular Medicine
Abstract
The intramolecular conformational equilibria between RNA hairpin and G-quadruplex in the 5’-UTRs of proto-oncogenes serve as attractive therapeutic targets. Tetraphenylethene (TPE) derivatives are shown to modulate the translation by shifting the conformational equilibria towards G-quadruplexes. The results suggest that the small molecule-mediated conformational shift in RNA can be used to modulate regulatory function for therapy.
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Gupta P. et al. Tetraphenylethene Derivatives Modulate the RNA Hairpin‐G‐Quadruplex Conformational Equilibria in Proto‐oncogenes** // ChemBioChem. 2022. Vol. 23. No. 12.
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Gupta P., Ojha D., Nadimetla D. N., Bhosale S. V., Rode A. B. Tetraphenylethene Derivatives Modulate the RNA Hairpin‐G‐Quadruplex Conformational Equilibria in Proto‐oncogenes** // ChemBioChem. 2022. Vol. 23. No. 12.
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TY - JOUR
DO - 10.1002/cbic.202200131
UR - https://doi.org/10.1002/cbic.202200131
TI - Tetraphenylethene Derivatives Modulate the RNA Hairpin‐G‐Quadruplex Conformational Equilibria in Proto‐oncogenes**
T2 - ChemBioChem
AU - Gupta, Payal
AU - Ojha, Divya
AU - Nadimetla, Dinesh N.
AU - Bhosale, Sheshanath V.
AU - Rode, Ambadas B.
PY - 2022
DA - 2022/05/11
PB - Wiley
IS - 12
VL - 23
SN - 1439-4227
SN - 1439-7633
ER -
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@article{2022_Gupta,
author = {Payal Gupta and Divya Ojha and Dinesh N. Nadimetla and Sheshanath V. Bhosale and Ambadas B. Rode},
title = {Tetraphenylethene Derivatives Modulate the RNA Hairpin‐G‐Quadruplex Conformational Equilibria in Proto‐oncogenes**},
journal = {ChemBioChem},
year = {2022},
volume = {23},
publisher = {Wiley},
month = {may},
url = {https://doi.org/10.1002/cbic.202200131},
number = {12},
doi = {10.1002/cbic.202200131}
}