Total Synthesis of Indole-Derived Allocolchicine Analogues Exhibiting Strong Apoptosis-Inducing Activity
Nikolay Sitnikov
1
,
Janna Velder
2
,
Liliane Abodo
3
,
Nicole Cuvelier
4
,
Jörg M. Neudörfl
2
,
A. Prokop
3
,
Günter Krause
4
,
Aleksey Y Fedorov
1
,
3
Department of Pediatric Hematology/Oncology, Children's Hospital Köln, Amsterdamer Strasse 59, 50735 Köln (Germany)
|
Publication type: Journal Article
Publication date: 2012-08-27
scimago Q1
wos Q2
SJR: 0.981
CiteScore: 6.7
Impact factor: 3.7
ISSN: 09476539, 15213765
PubMed ID:
22927359
General Chemistry
Catalysis
Organic Chemistry
Abstract
Induced suicide of tumor cells: Analogues of the natural product allocolchicine containing an N-methylindole substructure (see scheme) were synthesized and found to exhibit pronounced cytotoxic and apoptosis-inducing activity against different tumor cell lines at low nanomolar or even sub-nanomolar concentrations.
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Metrics
36
Total citations:
36
Citations from 2024:
1
(2.78%)
Cite this
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RIS |
BibTex |
MLA
Cite this
GOST
Copy
Sitnikov N. et al. Total Synthesis of Indole-Derived Allocolchicine Analogues Exhibiting Strong Apoptosis-Inducing Activity // Chemistry - A European Journal. 2012. Vol. 18. No. 38. pp. 12096-12102.
GOST all authors (up to 50)
Copy
Sitnikov N., Velder J., Abodo L., Cuvelier N., Neudörfl J. M., Prokop A., Krause G., Fedorov A. Y., Schmalz H. Total Synthesis of Indole-Derived Allocolchicine Analogues Exhibiting Strong Apoptosis-Inducing Activity // Chemistry - A European Journal. 2012. Vol. 18. No. 38. pp. 12096-12102.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/chem.201200083
UR - https://doi.org/10.1002/chem.201200083
TI - Total Synthesis of Indole-Derived Allocolchicine Analogues Exhibiting Strong Apoptosis-Inducing Activity
T2 - Chemistry - A European Journal
AU - Sitnikov, Nikolay
AU - Velder, Janna
AU - Abodo, Liliane
AU - Cuvelier, Nicole
AU - Neudörfl, Jörg M.
AU - Prokop, A.
AU - Krause, Günter
AU - Fedorov, Aleksey Y
AU - Schmalz, H.-G.
PY - 2012
DA - 2012/08/27
PB - Wiley
SP - 12096-12102
IS - 38
VL - 18
PMID - 22927359
SN - 0947-6539
SN - 1521-3765
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2012_Sitnikov,
author = {Nikolay Sitnikov and Janna Velder and Liliane Abodo and Nicole Cuvelier and Jörg M. Neudörfl and A. Prokop and Günter Krause and Aleksey Y Fedorov and H.-G. Schmalz},
title = {Total Synthesis of Indole-Derived Allocolchicine Analogues Exhibiting Strong Apoptosis-Inducing Activity},
journal = {Chemistry - A European Journal},
year = {2012},
volume = {18},
publisher = {Wiley},
month = {aug},
url = {https://doi.org/10.1002/chem.201200083},
number = {38},
pages = {12096--12102},
doi = {10.1002/chem.201200083}
}
Cite this
MLA
Copy
Sitnikov, Nikolay, et al. “Total Synthesis of Indole-Derived Allocolchicine Analogues Exhibiting Strong Apoptosis-Inducing Activity.” Chemistry - A European Journal, vol. 18, no. 38, Aug. 2012, pp. 12096-12102. https://doi.org/10.1002/chem.201200083.