A Magnetic Chameleon: Biocompatible Lanthanide Fluoride Nanoparticles with Magnetic Field Dependent Tunable Contrast Properties as a Versatile Contrast Agent for Low to Ultrahigh Field MRI and Optical Imaging in Biological Window
Silvanose Biju
1
,
Juan E. Gallo
2
,
Manuel Bañobre López
2
,
Bella B. Manshian
3
,
Stefaan J. Soenen
3
,
Willy Gsell
3
,
Luce Vander Elst
4
,
Publication type: Journal Article
Publication date: 2018-04-26
scimago Q1
wos Q2
SJR: 0.981
CiteScore: 6.7
Impact factor: 3.7
ISSN: 09476539, 15213765
PubMed ID:
29575427
General Chemistry
Catalysis
Organic Chemistry
Abstract
A novel type of multimodal, magnetic resonance imaging/optical imaging (MRI/OI) contrast agent was developed, based on core-shell lanthanide fluoride nanoparticles composed of a β-NaHoF4 core plus a β-NaGdF4:Yb3+ , Tm3+ shell with an average size of ∼24 nm. The biocompatibility of the particles was ensured by a surface modification with poly acrylic acid (PAA) and further functionalization with an affinity ligand, folic acid (FA). When excited using 980 nm near infrared (NIR) radiation, the contrast agent (CA) shows intense emission at 802 nm with lifetime of 791±3 μs, due to the transition 3 H4 →3 H6 of Tm3+ . Proton nuclear magnetic relaxation dispersion (1 H-NMRD) studies and magnetic resonance (MR) phantom imaging showed that the newly synthesized nanoparticles, decorated with poly(acrylic acid) and folic acid on the surface (NP-PAA-FA), can act mainly as a T1 -weighted contrast agent below 1.5 T, a T1 /T2 dual-weighted contrast agent at 3 T, and as highly efficient T2 -weighted contrast agent at ultrahigh fields. In addition, NP-PAA-FA showed very low cytotoxicity and no detectable cellular damage up to a dose of 500 μg mL-1 .
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Total citations:
27
Citations from 2025:
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(7.41%)
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Biju S. et al. A Magnetic Chameleon: Biocompatible Lanthanide Fluoride Nanoparticles with Magnetic Field Dependent Tunable Contrast Properties as a Versatile Contrast Agent for Low to Ultrahigh Field MRI and Optical Imaging in Biological Window // Chemistry - A European Journal. 2018. Vol. 24. No. 29. pp. 7388-7397.
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Biju S., Gallo J. E., Bañobre López M., Manshian B. B., Soenen S. J., Gsell W., Vander Elst L., Parac-Vogt T. N. A Magnetic Chameleon: Biocompatible Lanthanide Fluoride Nanoparticles with Magnetic Field Dependent Tunable Contrast Properties as a Versatile Contrast Agent for Low to Ultrahigh Field MRI and Optical Imaging in Biological Window // Chemistry - A European Journal. 2018. Vol. 24. No. 29. pp. 7388-7397.
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TY - JOUR
DO - 10.1002/chem.201800283
UR - https://doi.org/10.1002/chem.201800283
TI - A Magnetic Chameleon: Biocompatible Lanthanide Fluoride Nanoparticles with Magnetic Field Dependent Tunable Contrast Properties as a Versatile Contrast Agent for Low to Ultrahigh Field MRI and Optical Imaging in Biological Window
T2 - Chemistry - A European Journal
AU - Biju, Silvanose
AU - Gallo, Juan E.
AU - Bañobre López, Manuel
AU - Manshian, Bella B.
AU - Soenen, Stefaan J.
AU - Gsell, Willy
AU - Vander Elst, Luce
AU - Parac-Vogt, T. N.
PY - 2018
DA - 2018/04/26
PB - Wiley
SP - 7388-7397
IS - 29
VL - 24
PMID - 29575427
SN - 0947-6539
SN - 1521-3765
ER -
Cite this
BibTex (up to 50 authors)
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@article{2018_Biju,
author = {Silvanose Biju and Juan E. Gallo and Manuel Bañobre López and Bella B. Manshian and Stefaan J. Soenen and Willy Gsell and Luce Vander Elst and T. N. Parac-Vogt},
title = {A Magnetic Chameleon: Biocompatible Lanthanide Fluoride Nanoparticles with Magnetic Field Dependent Tunable Contrast Properties as a Versatile Contrast Agent for Low to Ultrahigh Field MRI and Optical Imaging in Biological Window},
journal = {Chemistry - A European Journal},
year = {2018},
volume = {24},
publisher = {Wiley},
month = {apr},
url = {https://doi.org/10.1002/chem.201800283},
number = {29},
pages = {7388--7397},
doi = {10.1002/chem.201800283}
}
Cite this
MLA
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Biju, Silvanose, et al. “A Magnetic Chameleon: Biocompatible Lanthanide Fluoride Nanoparticles with Magnetic Field Dependent Tunable Contrast Properties as a Versatile Contrast Agent for Low to Ultrahigh Field MRI and Optical Imaging in Biological Window.” Chemistry - A European Journal, vol. 24, no. 29, Apr. 2018, pp. 7388-7397. https://doi.org/10.1002/chem.201800283.