Wiley
ChemMedChem
,  volume 8 ,  issue 2 ,  pages 226-230

A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents

Haijun Chen 1
, 
Cheng Z Wang 2
, 
Chunyong Ding 2
, 
Christopher Wild 2
, 
Bryan A. Copits 3
, 
Geoffrey T. Swanson 4
, 
Kenneth M. Johnson 5
, 
Jia Zhou 5
1
 
2
 
3
 
4
 
5
 
Publication type: Journal Article
Publication date: 2012-12-20
Wiley
scimago Q1
wos Q2
SJR: 0.717
CiteScore: 6.7
Impact factor: 3.4
ISSN: 18607179, 18607187
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Molecular Medicine
General Pharmacology, Toxicology and Pharmaceutics
Abstract
PAMs new in town! An effective, combined bioinformatics and chemoinformatics approach was applied to the design of novel asymmetric bivalent α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor positive allosteric modulators (PAMs) with marked potency in vitro and efficacy in vivo for preventing neuroapoptosis. The novel chemotype could provide pharmacological probes and potential therapeutic agents for glutamatergic hypofunction and its related neurological and psychiatric disorders.
Found 
Found 

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GOST |
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GOST Copy
Chen H. et al. A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents // ChemMedChem. 2012. Vol. 8. No. 2. pp. 226-230.
GOST all authors (up to 50) Copy
Chen H., Wang C. Z., Ding C., Wild C., Copits B. A., Swanson G. T., Johnson K. M., Zhou J. A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents // ChemMedChem. 2012. Vol. 8. No. 2. pp. 226-230.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1002/cmdc.201200554
UR - https://doi.org/10.1002/cmdc.201200554
TI - A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents
T2 - ChemMedChem
AU - Chen, Haijun
AU - Wang, Cheng Z
AU - Ding, Chunyong
AU - Wild, Christopher
AU - Copits, Bryan A.
AU - Swanson, Geoffrey T.
AU - Johnson, Kenneth M.
AU - Zhou, Jia
PY - 2012
DA - 2012/12/20
PB - Wiley
SP - 226-230
IS - 2
VL - 8
PMID - 23281122
SN - 1860-7179
SN - 1860-7187
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2012_Chen,
author = {Haijun Chen and Cheng Z Wang and Chunyong Ding and Christopher Wild and Bryan A. Copits and Geoffrey T. Swanson and Kenneth M. Johnson and Jia Zhou},
title = {A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents},
journal = {ChemMedChem},
year = {2012},
volume = {8},
publisher = {Wiley},
month = {dec},
url = {https://doi.org/10.1002/cmdc.201200554},
number = {2},
pages = {226--230},
doi = {10.1002/cmdc.201200554}
}
MLA
Cite this
MLA Copy
Chen, Haijun, et al. “A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents.” ChemMedChem, vol. 8, no. 2, Dec. 2012, pp. 226-230. https://doi.org/10.1002/cmdc.201200554.