ChemMedChem, volume 16, issue 1, pages 65-80

Therapeutic Strategies To Counteract Antibiotic Resistance in MRSA Biofilm‐Associated Infections

Cascioferro Stella ¹

Carbone Daniela ¹

Parrino Barbara ¹

Pecoraro Camilla ¹

Giovannetti Elisa ^{2, 3}

Cirrincione Girolamo ¹

Diana Patrizia ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF) University of Palermo Via Archirafi 32 90123 Palermo Italy |

Department of Medical Oncology Cancer Center Amsterdam VU University Medical Center (VUmc) De Boelelaan 1117 1081HV Amsterdam The Netherlands |

Cancer Pharmacology Lab, AIRC Start Up Fondazione Pisana per la Scienza Via Ferruccio Giovannini 13 56017, San Giuliano Terme Pisa Italy |

Publication type: Journal Article

Publication date: 2020-11-06

Wiley

Journal: ChemMedChem

Quartile SCImago

Quartile WOS

Impact factor: 3.4

ISSN: 18607179, 18607187

DOI: 10.1002/cmdc.202000677

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Organic Chemistry

Drug Discovery

Biochemistry

Pharmacology

Molecular Medicine

General Pharmacology, Toxicology and Pharmaceutics

Abstract

Methicillin‐resistant Staphylococcus aureus (MRSA) has emerged as one of the leading causes of persistent human infections. This pathogen is widespread and is able to colonize asymptomatically about a third of the population, causing moderate to severe infections. It is currently considered the most common cause of nosocomial infections and one of the main causes of death in hospitalized patients. Due to its high morbidity and mortality rate and its ability to resist most antibiotics on the market, it has been termed a “superbug”. Its ability to form biofilms on biotic and abiotic surfaces seems to be the primarily means of MRSA antibiotic resistance and pervasiveness. Importantly, more than 80 % of bacterial infections are biofilm‐mediated. Biofilm formation on indwelling catheters, prosthetic devices and implants is recognized as the cause of serious chronic infections in hospital environments. In this review we discuss the most relevant literature of the last five years concerning the development of synthetic small molecules able to inhibit biofilm formation or to eradicate or disperse pre‐formed biofilms in the fight against MRSA diseases. The aim is to provide guidelines for the development of new anti‐virulence strategies based on the knowledge so far acquired, and, to identify the main flaws of this research field, which have hindered the generation of new market‐approved anti‐MRSA drugs that are able to act against biofilm‐associated infections

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Citations by journals

	1 2 3 4 5 6
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 6, 6.9% International Journal of Molecular Sciences 6 publications, 6.9%
Microorganisms	Microorganisms, 4, 4.6% Microorganisms 4 publications, 4.6%
Pathogens	Pathogens, 4, 4.6% Pathogens 4 publications, 4.6%
Antibiotics	Antibiotics, 4, 4.6% Antibiotics 4 publications, 4.6%
Frontiers in Microbiology	Frontiers in Microbiology, 4, 4.6% Frontiers in Microbiology 4 publications, 4.6%
Molecules	Molecules, 3, 3.45% Molecules 3 publications, 3.45%
Frontiers in Pharmacology	Frontiers in Pharmacology, 3, 3.45% Frontiers in Pharmacology 3 publications, 3.45%
Microbiology spectrum	Microbiology spectrum, 3, 3.45% Microbiology spectrum 3 publications, 3.45%
Pharmaceuticals	Pharmaceuticals, 2, 2.3% Pharmaceuticals 2 publications, 2.3%
Biomedicines	Biomedicines, 2, 2.3% Biomedicines 2 publications, 2.3%
Folia Microbiologica	Folia Microbiologica, 2, 2.3% Folia Microbiologica 2 publications, 2.3%
Scientific Reports	Scientific Reports, 2, 2.3% Scientific Reports 2 publications, 2.3%
International Journal of Pharmaceutics	International Journal of Pharmaceutics, 2, 2.3% International Journal of Pharmaceutics 2 publications, 2.3%
Chemistry and Biodiversity	Chemistry and Biodiversity, 2, 2.3% Chemistry and Biodiversity 2 publications, 2.3%
Infection and Drug Resistance	Infection and Drug Resistance, 2, 2.3% Infection and Drug Resistance 2 publications, 2.3%
Frontiers in Cellular and Infection Microbiology	Frontiers in Cellular and Infection Microbiology, 2, 2.3% Frontiers in Cellular and Infection Microbiology 2 publications, 2.3%
Pharmaceutics	Pharmaceutics, 1, 1.15% Pharmaceutics 1 publication, 1.15%
Diagnostics	Diagnostics, 1, 1.15% Diagnostics 1 publication, 1.15%
Research on Chemical Intermediates	Research on Chemical Intermediates, 1, 1.15% Research on Chemical Intermediates 1 publication, 1.15%
Journal of Nanobiotechnology	Journal of Nanobiotechnology, 1, 1.15% Journal of Nanobiotechnology 1 publication, 1.15%
Annals of Clinical Microbiology and Antimicrobials	Annals of Clinical Microbiology and Antimicrobials, 1, 1.15% Annals of Clinical Microbiology and Antimicrobials 1 publication, 1.15%
World Journal of Microbiology and Biotechnology	World Journal of Microbiology and Biotechnology, 1, 1.15% World Journal of Microbiology and Biotechnology 1 publication, 1.15%
Biomaterials Advances	Biomaterials Advances, 1, 1.15% Biomaterials Advances 1 publication, 1.15%
Results in Chemistry	Results in Chemistry, 1, 1.15% Results in Chemistry 1 publication, 1.15%
Bioorganic Chemistry	Bioorganic Chemistry, 1, 1.15% Bioorganic Chemistry 1 publication, 1.15%
Microbial Pathogenesis	Microbial Pathogenesis, 1, 1.15% Microbial Pathogenesis 1 publication, 1.15%
European Journal of Medicinal Chemistry	European Journal of Medicinal Chemistry, 1, 1.15% European Journal of Medicinal Chemistry 1 publication, 1.15%
Biofilm	Biofilm, 1, 1.15% Biofilm 1 publication, 1.15%
Process Biochemistry	Process Biochemistry, 1, 1.15% Process Biochemistry 1 publication, 1.15%
Journal of Photochemistry and Photobiology A: Chemistry	Journal of Photochemistry and Photobiology A: Chemistry, 1, 1.15% Journal of Photochemistry and Photobiology A: Chemistry 1 publication, 1.15%
	1 2 3 4 5 6

Citations by publishers

	5 10 15 20 25 30
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 28, 32.18% Multidisciplinary Digital Publishing Institute (MDPI) 28 publications, 32.18%
Elsevier	Elsevier, 14, 16.09% Elsevier 14 publications, 16.09%
Springer Nature	Springer Nature, 12, 13.79% Springer Nature 12 publications, 13.79%
Frontiers Media S.A.	Frontiers Media S.A., 9, 10.34% Frontiers Media S.A. 9 publications, 10.34%
Wiley	Wiley, 8, 9.2% Wiley 8 publications, 9.2%
Taylor & Francis	Taylor & Francis, 4, 4.6% Taylor & Francis 4 publications, 4.6%
American Society for Microbiology	American Society for Microbiology, 4, 4.6% American Society for Microbiology 4 publications, 4.6%
Dove Medical Press	Dove Medical Press, 2, 2.3% Dove Medical Press 2 publications, 2.3%
Hindawi Limited	Hindawi Limited, 1, 1.15% Hindawi Limited 1 publication, 1.15%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 1.15% American Chemical Society (ACS) 1 publication, 1.15%
Oxford University Press	Oxford University Press, 1, 1.15% Oxford University Press 1 publication, 1.15%
Asian Network for Scientific Information	Asian Network for Scientific Information, 1, 1.15% Asian Network for Scientific Information 1 publication, 1.15%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 1.15% Royal Society of Chemistry (RSC) 1 publication, 1.15%
Future Medicine	Future Medicine, 1, 1.15% Future Medicine 1 publication, 1.15%
	5 10 15 20 25 30

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Cascioferro S. et al. Therapeutic Strategies To Counteract Antibiotic Resistance in MRSA Biofilm‐Associated Infections // ChemMedChem. 2020. Vol. 16. No. 1. pp. 65-80.

GOST all authors (up to 50) Copy

Cascioferro S., Carbone D., Parrino B., Pecoraro C., Giovannetti E., Cirrincione G., Diana P. Therapeutic Strategies To Counteract Antibiotic Resistance in MRSA Biofilm‐Associated Infections // ChemMedChem. 2020. Vol. 16. No. 1. pp. 65-80.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1002/cmdc.202000677

UR - https://doi.org/10.1002%2Fcmdc.202000677

TI - Therapeutic Strategies To Counteract Antibiotic Resistance in MRSA Biofilm‐Associated Infections

T2 - ChemMedChem

AU - Cirrincione, Girolamo

AU - Cascioferro, Stella

AU - Carbone, Daniela

AU - Parrino, Barbara

AU - Pecoraro, Camilla

AU - Giovannetti, Elisa

AU - Diana, Patrizia

PY - 2020

DA - 2020/11/06 00:00:00

PB - Wiley

SP - 65-80

IS - 1

VL - 16

SN - 1860-7179

SN - 1860-7187

ER -

BibTex |

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BibTex Copy

@article{2020_Cascioferro,

author = {Girolamo Cirrincione and Stella Cascioferro and Daniela Carbone and Barbara Parrino and Camilla Pecoraro and Elisa Giovannetti and Patrizia Diana},

title = {Therapeutic Strategies To Counteract Antibiotic Resistance in MRSA Biofilm‐Associated Infections},

journal = {ChemMedChem},

year = {2020},

volume = {16},

publisher = {Wiley},

month = {nov},

url = {https://doi.org/10.1002%2Fcmdc.202000677},

number = {1},

pages = {65--80},

doi = {10.1002/cmdc.202000677}

}

MLA

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MLA Copy

Cascioferro, Stella, et al. “Therapeutic Strategies To Counteract Antibiotic Resistance in MRSA Biofilm‐Associated Infections.” ChemMedChem, vol. 16, no. 1, Nov. 2020, pp. 65-80. https://doi.org/10.1002%2Fcmdc.202000677.

Found error?

Publisher

Wiley

Journal

ChemMedChem

Quartile SCImago

Quartile WOS

Impact factor

3.4

ISSN

18607179 (Print)
18607187 (Electronic)