Rh(III)‐Catalyzed Redox‐Neutral [4+2] Annulation for Direct Assembly of 3‐Acyl Isoquinolin‐1(2 H )‐ones as Potent Antitumor Agents
Тип публикации: Journal Article
Дата публикации: 2020-03-01
scimago Q2
wos Q2
БС2
SJR: 0.730
CiteScore: 4.4
Impact factor: 2.8
ISSN: 21926506
PubMed ID:
32118370
General Chemistry
Краткое описание
By virtue of an efficient rhodium(III)-catalyzed redox-neutral C-H activation/ring-opening of a strained ring/[4+2] annulation cascade of N-methoxybenzamides with propargyl cycloalkanols, diverse 3-acyl isoquinolin-1(2H)-ones were directly obtained in good yields and with excellent functional group compatibility. Additionally, their antitumor activities against various human cancer cells including HepG2, A549, MCF-7 and SH-SY5Y were evaluated and the action mechanism of the selected compound was also investigated in vitro. The results revealed that these products possessed a potent efficacy, by inhibiting proliferation and inducing apoptosis in a time-dependent and dose-dependent manner, suggesting that such compounds can serve as promising candidates for anti lung cancer drug discovery.
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Bian M. et al. Rh(III)‐Catalyzed Redox‐Neutral [4+2] Annulation for Direct Assembly of 3‐Acyl Isoquinolin‐1(2 H )‐ones as Potent Antitumor Agents // ChemPlusChem. 2020. Vol. 85. No. 3. pp. 405-410.
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Bian M., Ma L., Wu M., Wu L., Gao H., Yi W., Zhang C., Zhou Z. Rh(III)‐Catalyzed Redox‐Neutral [4+2] Annulation for Direct Assembly of 3‐Acyl Isoquinolin‐1(2 H )‐ones as Potent Antitumor Agents // ChemPlusChem. 2020. Vol. 85. No. 3. pp. 405-410.
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TY - JOUR
DO - 10.1002/cplu.201900616
UR - https://doi.org/10.1002/cplu.201900616
TI - Rh(III)‐Catalyzed Redox‐Neutral [4+2] Annulation for Direct Assembly of 3‐Acyl Isoquinolin‐1(2 H )‐ones as Potent Antitumor Agents
T2 - ChemPlusChem
AU - Bian, Mengyao
AU - Ma, Lei
AU - Wu, Min
AU - Wu, Liexin
AU - Gao, Hui
AU - Yi, Wei
AU - Zhang, Chao
AU - Zhou, Zhi
PY - 2020
DA - 2020/03/01
PB - Wiley
SP - 405-410
IS - 3
VL - 85
PMID - 32118370
SN - 2192-6506
ER -
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@article{2020_Bian,
author = {Mengyao Bian and Lei Ma and Min Wu and Liexin Wu and Hui Gao and Wei Yi and Chao Zhang and Zhi Zhou},
title = {Rh(III)‐Catalyzed Redox‐Neutral [4+2] Annulation for Direct Assembly of 3‐Acyl Isoquinolin‐1(2 H )‐ones as Potent Antitumor Agents},
journal = {ChemPlusChem},
year = {2020},
volume = {85},
publisher = {Wiley},
month = {mar},
url = {https://doi.org/10.1002/cplu.201900616},
number = {3},
pages = {405--410},
doi = {10.1002/cplu.201900616}
}
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MLA
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Bian, Mengyao, et al. “Rh(III)‐Catalyzed Redox‐Neutral [4+2] Annulation for Direct Assembly of 3‐Acyl Isoquinolin‐1(2 H )‐ones as Potent Antitumor Agents.” ChemPlusChem, vol. 85, no. 3, Mar. 2020, pp. 405-410. https://doi.org/10.1002/cplu.201900616.