Thirty Years of the Drug Candidate NAMI‐A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective
Publication type: Journal Article
Publication date: 2016-09-28
scimago Q2
wos Q3
SJR: 0.459
CiteScore: 3.9
Impact factor: 2.0
ISSN: 14341948, 10990682
Inorganic Chemistry
Abstract
As anticipated in the title, this contribution is basically divided into two, strictly connected, parts. The first is a personal overview of the ruthenium drug candidate NAMI-A, almost 30 years after its synthesis and the discovery of its unprecedented antimetastatic properties in animal models at nontoxic dosages. The sections relating to the chemical and biological behavior of the complex, and the hypotheses on its mechanism(s) of action, are kept to a minimum, whereas more space is devoted to discussion of the results of the clinical investigations. The second part deals in detail with a number of undemonstrated misconceptions (or myths) that, over the years, have thrived around NAMI-A and other ruthenium drug candidates, thus negatively affecting the whole field of Ru anticancer drugs.
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Total citations:
342
Citations from 2025:
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GOST
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Alessio E. Thirty Years of the Drug Candidate NAMI‐A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective // European Journal of Inorganic Chemistry. 2016. Vol. 2017. No. 12. pp. 1549-1560.
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Alessio E. Thirty Years of the Drug Candidate NAMI‐A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective // European Journal of Inorganic Chemistry. 2016. Vol. 2017. No. 12. pp. 1549-1560.
Cite this
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TY - JOUR
DO - 10.1002/ejic.201600986
UR - https://doi.org/10.1002/ejic.201600986
TI - Thirty Years of the Drug Candidate NAMI‐A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective
T2 - European Journal of Inorganic Chemistry
AU - Alessio, Enzo
PY - 2016
DA - 2016/09/28
PB - Wiley
SP - 1549-1560
IS - 12
VL - 2017
SN - 1434-1948
SN - 1099-0682
ER -
Cite this
BibTex (up to 50 authors)
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@article{2016_Alessio,
author = {Enzo Alessio},
title = {Thirty Years of the Drug Candidate NAMI‐A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective},
journal = {European Journal of Inorganic Chemistry},
year = {2016},
volume = {2017},
publisher = {Wiley},
month = {sep},
url = {https://doi.org/10.1002/ejic.201600986},
number = {12},
pages = {1549--1560},
doi = {10.1002/ejic.201600986}
}
Cite this
MLA
Copy
Alessio, Enzo. “Thirty Years of the Drug Candidate NAMI‐A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective.” European Journal of Inorganic Chemistry, vol. 2017, no. 12, Sep. 2016, pp. 1549-1560. https://doi.org/10.1002/ejic.201600986.